scholarly journals Jean Cruveilhier and his contributions to understanding childhood hydrocephalus, Chiari II malformation, and spina bifida

2017 ◽  
Vol 34 (9) ◽  
pp. 1613-1615 ◽  
Author(s):  
Michele Davis ◽  
Marios Loukas ◽  
R. Shane Tubbs
Keyword(s):  
Spina Bifida ◽  
Chiari Ii Malformation ◽  
Chiari Ii ◽  
Childhood Hydrocephalus

Trans-amniotic stem cell therapy (TRASCET) minimizes Chiari-II malformation in experimental spina bifida

2015 ◽  
Vol 50 (6) ◽  
pp. 1037-1041 ◽  
Author(s):  
Beatrice Dionigi ◽  
Joseph A. Brazzo ◽  
Azra Ahmed ◽  
Christina Feng ◽  
Yaotang Wu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Spina Bifida ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Chiari Ii Malformation ◽  
Chiari Ii

Care management and contemporary challenges in spina bifida: a practice preference survey of the American Society of Pediatric Neurosurgeons

2019 ◽  
Vol 24 (5) ◽  
pp. 539-548 ◽  
Author(s):  
Elizabeth N. Alford ◽  
Betsy D. Hopson ◽  
Frederick Safyanov ◽  
Anastasia Arynchyna ◽  
Robert J. Bollo ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Tethered Cord ◽  
Transition Program ◽  
Shunt Revision ◽  
Csf Leak ◽  
Urinary Continence ◽  
Ventricular Enlargement ◽  
Chiari Ii Malformation ◽  
Chiari Ii ◽  
American Society

OBJECTIVENeurosurgical management preferences related to myelomeningocele (MMC) care demonstrate significant variability. The authors sought to evaluate variability in practice patterns across a group of senior pediatric neurosurgeons. The purpose of this study was to identify the extent of variability and of consensus with regard to neurosurgical management of MMC and associated hydrocephalus, Chiari II malformation, and tethered spinal cord.METHODSA 43-question survey was distributed electronically to the members of the American Society of Pediatric Neurosurgeons (ASPN). The survey covered domains such as clinic case volume, newborn management, hydrocephalus management, transition to adulthood, clinical indications for shunt revision, Chiari II malformation decompression (C2MD), and tethered cord release (TCR). Ninety responses were received from 200 active ASPN members, for an overall response rate of 45%.RESULTSThe majority (58%) of respondents closed 5–15 new cases of open MMC per year. Nearly all (98%) respondents perform back closure within 48 hours of birth, with the majority imbricating the placode and striving for a 3- to 4-layer closure. The most consistent indications for surgical intervention in early hydrocephalus were CSF leak from the back (92%), progressive ventricular enlargement (89%), and brainstem symptoms, including apnea/bradycardia (81%), stridor (81%), and dysphagia (81%). Eighty percent of respondents indicated that spina bifida care is delivered through multidisciplinary clinics, with neurosurgery, orthopedic surgery, urology, physical therapy, and social work as the most common disciplines included. One-third of clinics see both pediatric and adult patients, one-third offer a formal transition program to adult care, and one-third have no transition program. The vast majority of respondents offer prenatal counseling (95%), referral for in utero closure (66%), and endoscopic third ventriculostomy/choroid plexus cauterization (72%). Respondents were more willing to perform shunt revision for symptoms alone than for image changes alone. An asymptomatic broken shunt without ventricular enlargement produced responses evenly divided between observation, intervention, and further investigation. Operative shunt exploration was always performed before C2MD by 56% of respondents and performed sometimes by 40% of respondents. Symptoms of brainstem dysfunction were the strongest clinical triggers reported for C2MD, while declines in urinary continence, leg strength or sensation, or ambulation were the most consistent thresholds for TCR.CONCLUSIONSSignificant disparities exist surrounding key areas of decision making regarding treatment for patients with MMC, though there are central areas of agreement among ASPN members. Additionally, there is significant variation in the clinical management of chronic hydrocephalus, C2MD, and TCR, underscoring the need for further research into these specific areas.

scholarly journals The Cerebellum in Children with Spina Bifida and Chiari II Malformation: Quantitative Volumetrics by Region

2010 ◽  
Vol 9 (2) ◽  
pp. 240-248 ◽  
Author(s):  
Jenifer Juranek ◽  
Maureen Dennis ◽  
Paul T. Cirino ◽  
Lyla El-Messidi ◽  
Jack M. Fletcher
Keyword(s):  
Spina Bifida ◽  
Chiari Ii Malformation ◽  
Chiari Ii

Cerebral Abnormalities in Spina Bifida: A Neuropathological Study

2021 ◽  
pp. 109352662110405
Author(s):  
Fabienne Paschereit ◽  
Kim Hannah Schindelmann ◽  
Michael Hummel ◽  
Joanna Schneider ◽  
Gisela Stoltenburg-Didinger ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Chiari Ii Malformation ◽  
Brain Anomalies ◽  
Radiologic Study ◽  
Brain Malformations ◽  
High Prevalence ◽  
Cerebellar Malformations ◽  
Case Files ◽  
Chiari Ii ◽  
Gestational Week

Introduction Spina bifida (SB) is the most common neural tube defect in humans. Here, we analyzed systematically the neuropathological findings of the brain in SB cases. Methods 79 cases with SB aperta (SBA) and 6 cases with SB occulta (SBO) autopsied at the Charité Neuropathology from 1974 to 2000 were re-evaluated retrospectively. For this, case files and spinal cord as well as brain sections were studied. Results While no brain malformations were detected in SBO cases, 95% of SBA cases had brain malformations. Main brain anomalies identified were hydrocephalus (71%), Chiari II malformation (36%), heterotopia (34%), other cerebellar anomalies (36%), gyrification defects (33%), and ependymal denudation (29%). Hydrocephalus was observed as early as gestational week 17 and was highly associated to Chiari II and ependymal denudation. In 55% SBA was accompanied by further anomalies not primarily affecting the CNS. Conclusion We confirm using neuropathologic methods brain malformations in most SBA but none in SBO cases. In addition to our previous radiologic study, we now demonstrate the high prevalence of cerebellar malformations and cerebral heterotopias in SBA. The early detection of hydrocephalus and Chiari II malformation in fetuses raises the question whether these arise parallel rather than in strict temporal sequence.

Kurzfristiges Outcome der fetoskopischen Patchapplikation bei offener Spina bifida und Chiari II Malformation anhand eines Fallbeispiels

2017 ◽  
Vol 77 (04) ◽  
pp. 406-429
Author(s):  
A Lauten ◽  
G Skirl ◽  
A Waschke ◽  
K Dawczynski ◽  
U Schneider
Keyword(s):  
Spina Bifida ◽  
Chiari Ii Malformation ◽  
Chiari Ii

Cognitive and functional outcome in spina bifida–Chiari II malformation

2010 ◽  
Vol 27 (6) ◽  
pp. 967-974 ◽  
Author(s):  
Michael D. Jenkinson ◽  
Sophie Campbell ◽  
Caroline Hayhurst ◽  
Simon Clark ◽  
Jothy Kandasamy ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Functional Outcome ◽  
Chiari Ii Malformation ◽  
Chiari Ii
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