Management of ulcerative colitis pre- and post-liver transplant for primary sclerosing cholangitis: two case reports and review of literature

2014 ◽  
Vol 29 (11) ◽  
pp. 1313-1320 ◽  
Author(s):  
Kiranpreet Khosa ◽  
Kofi Clarke
Keyword(s):  
Ulcerative Colitis ◽  
Liver Transplant ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Case Reports ◽  
Review Of Literature

Restorative Proctocolectomy and Ileal Pouch–Anal Anastomosis for Ulcerative Colitis after Liver Transplant for Primary Sclerosing Cholangitis: Case Report and Review of Literature

2005 ◽  
Vol 71 (4) ◽  
pp. 362-365 ◽  
Author(s):  
Alexis L. Grucela ◽  
Randolph M. Steinhagen
Keyword(s):  
Ulcerative Colitis ◽  
Liver Transplant ◽  
Primary Sclerosing Cholangitis ◽  
Restorative Proctocolectomy ◽  
Sclerosing Cholangitis ◽  
Ileal Pouch ◽  
Ileal Pouch Anal Anastomosis ◽  
Orthotopic Liver Transplant ◽  
Increased Risk ◽  
Anal Anastomosis

Primary sclerosing cholangitis (PSC) is present in 5 per cent of patients with ulcerative colitis (UC). Conversely, as many as 90 per cent of patients with PSC have been found to have UC. The accepted treatment for advanced PSC is orthotopic liver transplant, and the treatment of ulcerative colitis with concomitant PSC is restorative proctocolectomy with ileal pouch–anal anastomosis (IPAA). A small number of studies have shown that there is an increased risk of pouchitis in UC patients with PSC after ileal pouch-anal anastomosis. We report a case of a 45-year-old male who underwent a two-stage restorative proctocolectomy with IPAA after previous orthotopic liver transplant for PSC. We have reviewed the available literature concerning restorative proctocolectomy after liver transplantation, giving special attention to postoperative complications and subsequent development of pouchitis. It is important to be aware of the possibility of increased risk for development of pouchitis and to follow these patients closely to prevent complications.

scholarly journals Rapid Progression of Primary Sclerosing Cholangitis Complicated with Ulcerative Colitis

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Piotr Pardak ◽  
Ewa Walczak ◽  
Rafał S. Filip
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Liver Transplant ◽  
Primary Sclerosing Cholangitis ◽  
Bowel Disease ◽  
Sclerosing Cholangitis ◽  
Unknown Etiology ◽  
Rapid Progression ◽  
Inflammatory Bowel ◽  
Progressive Course

Primary sclerosing cholangitis is a cholestatic condition with unknown etiology and long-standing, progressive course, leading to cirrhosis and requiring orthotropic liver transplant. In approximately 80%, primary sclerosing cholangitis is accompanied by inflammatory bowel disease, and in most cases the recognition of bowel disease precedes the diagnosis of primary sclerosing cholangitis. We describe a case of 22-year-old male diagnosed simultaneously with primary sclerosing cholangitis and ulcerative colitis, with a medical history suggesting uncommon prior development of the liver disease. Five months after the initial diagnosis, we observed advanced lesions of bile tree due to progression of primary sclerosing cholangitis, which led to the unusually fast necessity for the orthotopic liver transplant.

Sign in / Sign up

Export Citation Format

Share Document