Successful pregnancy involving a man with chronic myeloid leukemia on dasatinib

2010 ◽  
Vol 283 (1) ◽  
pp. 133-134 ◽  
Author(s):  
Houssam Oweini ◽  
Zaher K. Otrock ◽  
Rami A. R. Mahfouz ◽  
Ali Bazarbachi
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Successful Pregnancy

scholarly journals Recurrence of Chronic Myeloid Leukemia during Pregnancy Subsequently Achieving Complete Medical Remission

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Sasha Mikhael ◽  
Ashlee Pascoe ◽  
Joseph Prezzato
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Animal Studies ◽  
Kinase Inhibitors ◽  
Adverse Outcomes ◽  
High Dose ◽  
Molecular Remission ◽  
Successful Pregnancy ◽  
Pregnancy And Delivery ◽  
Reproductive Aged Women

The treatment of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors (TKIs) in reproductive-aged women poses major dilemmas concerning its associated teratogenicity as observed in many animal studies. Much controversy exists regarding continuation versus discontinuation of its use in pregnancy with some studies suggesting safety of TKIs before and during pregnancy and others reporting toxicity and adverse outcomes. TKIs have become a well-established treatment option for CML, significantly improving prognosis, and yet have been reported to be fetotoxic. We present a case of a 25-year-old woman who achieved successful pregnancy and delivery after withholding treatment, meanwhile relapsing, eventually achieving complete molecular remission after reinitiation of high dose dasatinib.

Successful pregnancy and delivery during α-interferon therapy for chronic myeloid leukemia

1992 ◽  
Vol 40 (3) ◽  
pp. 238-239 ◽  
Author(s):  
Michael Crump ◽  
Xing-Hua Wang ◽  
Matthew Sermer ◽  
Armand Keating
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Interferon Therapy ◽  
Successful Pregnancy ◽  
Pregnancy And Delivery

scholarly journals Successful Pregnancy in a Patient with Chronic Myeloid Leukemia under Treatment with Imatinib

2009 ◽  
Vol 48 (16) ◽  
pp. 1433-1435 ◽  
Author(s):  
Motohiro Tsuzuki ◽  
Youko Inaguma ◽  
Kousuke Handa ◽  
Akio Hasegawa ◽  
Yukiya Yamamoto ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Successful Pregnancy

scholarly journals Successful Pregnancy and Delivery in a Patient with Chronic Myeloid Leukemia while on Dasatinib Therapy

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Monika Conchon ◽  
Sabri S. Sanabani ◽  
Mariana Serpa ◽  
Mafalda M. Y. Novaes ◽  
Luciana Nardinelli ◽  
...  
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Unplanned Pregnancy ◽  
Single Patient ◽  
Successful Pregnancy ◽  
Cesarean Section Delivery ◽  
Male Baby ◽  
Pregnancy And Delivery ◽  
Complete Hematological Response ◽  
Hematological Remission

Here we report the case of an 18-year-old woman with chronic myeloid leukemia (CML) who became pregnant while undergoing treatment with dasatinib. Before pregnancy, she received imatinib mesylate therapy but could not tolerate the treatment. The regimen was then changed to dasatinib at a dose of 70 mg b.i.d. While she was in hematological remission and on dasatinib therapy, she became pregnant. The unplanned pregnancy was identified after the patient had experienced four weeks of amenorrhea. Because the patient elected to continue the pregnancy to term, dasatinib was stopped immediately. Meanwhile, CML hematological relapse occurred and then she was treated with interferon- (IFN-) (9 million IU/day) throughout the pregnancy without a complete hematological response. She successfully gave birth to a male baby at 33 weeks by cesarean section delivery with no sequelae or malformations. Although this experience is limited to a single patient, it provides a useful contribution for counselling patients inadvertently exposed to dasatinib during pregnancy.

scholarly journals Successful Pregnancy Outcome in a Patient of Chronic Myeloid Leukemia Without Therapy

2011 ◽  
Vol 61 (5) ◽  
pp. 565-566 ◽  
Author(s):  
Joydeb Roychowdhury ◽  
Maitreyee Bhattacharyya ◽  
Arup Kumar Kundu ◽  
Madhavi Panfalia
Keyword(s):  
Chronic Myeloid Leukemia ◽  
Pregnancy Outcome ◽  
Myeloid Leukemia ◽  
Successful Pregnancy
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