Association between occurrence of ossicular chain defect and osteoprotegerin gene expression in patients with chronic otitis media

2019 ◽  
Vol 276 (5) ◽  
pp. 1321-1325
Author(s):  
Serhan Keskin ◽  
Arzu Tatlıpınar ◽  
Pınar Ata ◽  
Selami Uzun ◽  
Mustafa Emrah Kınal ◽  
...  
Keyword(s):  
Gene Expression ◽  
Otitis Media ◽  
Chronic Otitis Media ◽  
Ossicular Chain ◽  
Osteoprotegerin Gene

scholarly journals Scanning Electron Microscopy in the Evaluation of Defects to the Ossicular Chain in the Course of Chronic Otitis Media

2019 ◽  
pp. 014556131987391
Author(s):  
Agnieszka Wiatr ◽  
Katarzyna Swiezy ◽  
Jacek Skladzien ◽  
Maciej Wiatr
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Chronic Inflammation ◽  
Otitis Media ◽  
Middle Ear ◽  
Chronic Otitis Media ◽  
Ossicular Chain ◽  
Suppurative Otitis Media ◽  
Ear Ossicles ◽  
Scanning Electron

Objective: Chronic otitis media is a heterogeneous disorder. Chronic suppurative otitis media with cholesteatoma and, to a lesser extent, chronic otitis media with granulation lead to the destruction of bone structures within the middle ear. Bone loss may appear in the prominence of the horizontal semicircular canals and the bony canal of the facial nerve. The inflammatory process may spread to the bony labyrinth of the sigmoidal sinuses and the cranial cavities. Materials and Methods: The analysis comprised the examination of fragments of auditory ossicles removed during surgery in 21 patients with various types of chronic inflammation of the middle ear. The purpose of this study was to evaluate the usefulness of scanning electron microscopy in evaluating the erosion of middle ear ossicles in different types of chronic otitis media. Images captured at various magnifications were used for the best possible illustration of the observed lesions in bone tissue. Results: The observed lesions and the degree of bone surface damage were dependent on the type of chronic inflammation of the middle ear. The largest destructive changes in the ossicular chain were observed in chronic otitis media with cholesteatoma; smaller changes were observed in chronic otitis media with granulation. Conclusion: In the case of damage to the ossicles inflicted by inflammation, the use of a modeled bone block made of a temporal bone taken from outside the tympanic cavity or a biomaterial prosthesis is a good choice in ossiculoplasty.

scholarly journals Influence of Ossicular Chain Damage on Hearing After Chronic Otitis Media and Cholesteatoma Surgery

2015 ◽  
Vol 141 (11) ◽  
pp. 974 ◽  
Author(s):  
Erik F. Blom ◽  
Marlise N. Gunning ◽  
Nienke J. Kleinrensink ◽  
Alexander S. H. J. Lokin ◽  
Hanneke Bruijnzeel ◽  
...  
Keyword(s):  
Otitis Media ◽  
Chronic Otitis Media ◽  
Ossicular Chain ◽  
Cholesteatoma Surgery

scholarly journals OSSICULAR STATUS IN CHOLESTEATOMA : A DEPARTMENTAL EXPERIENCE IN A STATE MEDICAL COLLEGE OF WESTBENGAL.

2015 ◽  
Vol 23 (3) ◽  
pp. 116-119
Author(s):  
Somesh Mozumder ◽  
Arunabha Sengupta ◽  
Alok Ranjan Mondal ◽  
Soumik Basu
Keyword(s):  
Otitis Media ◽  
Clinical Examination ◽  
Middle Ear ◽  
Chronic Otitis Media ◽  
Ossicular Chain ◽  
Radiological Evaluation ◽  
Super Structure ◽  
Medical College ◽  
Middle Ear Cleft ◽  
Age And Sex

Introduction: Chronic otitis media is a long standing infection of part or whole of middle ear cleft. Its active squamosal variant (cholesteatoma) is most dangerous due to its bone eroding property. Aims & Objective: Background knowledge of ossicular status in cholesteatoma  will help us in determining the type  of reconstruction needed during the surgery. Material & methods: 60 cases of cholesteama, irrespective of age and sex [diagnosed on the basis of clinical examination , audiological and radiological evaluation] were selected during the study period of two years and their ossicular status were recorded intra-operatively. Results &  analysis: Ossicles and their parts getting involved in cholesteatoma cases , in decreasing order are : Lenticular process (in total 50 cases)>Long process of incus (in total 49 cases) > stapes super-structure(in total 29 cases) > body of incus(in total 26 cases)> head of malleus(in total 23 cases)> handle of malleus(in total 10 cases). Ossicular chain  defeact in decreasing order are : M-I-S- > M+I-S- > M-I-S+ > M+I-S+. Conclusion: In our study it was found that incus is the most vulnerable ossicle to get involved in cases of active squamosal variety of chronic otitis media where as malleus appeared to be the least susceptible one.

scholarly journals Relationship of Preoperative Hearing loss with Peroperative Ossicular Discontinuity in Chronic Otitis Media

2020 ◽  
Vol 25 (2) ◽  
pp. 94-101
Author(s):  
Nibash Chandra Ghosh ◽  
Kanu Lal Saha ◽  
Nasima Akhtar ◽  
Md Manjurul Islam ◽  
Arif Mahmud Jewel ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Otitis Media ◽  
Chronic Otitis Media ◽  
Ossicular Chain ◽  
Neck Surgery ◽  
P Value ◽  
Common Disease ◽  
Moderate Degree ◽  
Cross Sectional ◽  
Severe Degree

Background: Chronic Otitis Media (COM) is a common disease in our country. COM with or without cholesteatoma may lead to ossicular discontinuity. However, the discontinuity of the ossicular chain is usually confirmed during operation. The purpose of the study was to find out the correlation between preoperative hearing loss and the status of ossicular chain at surgery. Methods: This cross-sectional study was conducted in the department of otolaryngology- Head & neck surgery, Bangabandhu Sheikh Mujib Medical University from January 2013 to June 2014. At least 113 patients of COM were selected as per inclusion and exclusion criteria. Relevant data were collected in a predesigned data collection sheet and analyzed with standard statistical method. Statistically significant inferred for P value <0.05. No groups whose ability to give voluntary informed consent questionable was not included. No potential risks exist in designed this study. Results: Out of 34 patients with mild degree of hearing loss 31(39.7%) had intact ossicular chain whereas discontinuity was seen in 3(8.6%) cases, 37 patients with moderate degree of hearing loss 16(45.7%) had ossicular discontinuity. Among 23 patients with moderate to severe degree of hearing loss 14(17.9%) had intact ossicular chain whereas ossicular discontinuity was found 9(25.7%), 9 patients of severe degree of hearing loss 7(20%) had ossicular discontinuity. Cases with moderate and severe degree of hearing loss had significant ossicular discontinuity (p<0.05). Air-bone gap > 40 dB was found in 60% cases of ossicular discontinuity, followed by air bone gap 31-40 dB(17.14%), 21-30 dB(14.29%) and 11-20 dB( 8.57%) respectively. So ossicular discontinuity was in higher air-bone gap group and it was statistically significant (p<0.001). Bangladesh J Otorhinolaryngol; October 2019; 25(2): 94-101

Development and Validation of a Prognostic Model to Predict Hearing Recovery for Patients With Chronic Otitis Media

2021 ◽  
pp. 014556132110655
Author(s):  
Fengyang Xie ◽  
Xiaoyue Zhen ◽  
Haiyuan Zhu ◽  
Yan Kou ◽  
Changle Li ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Otitis Media ◽  
Validation Cohort ◽  
Area Under The Curve ◽  
Chronic Otitis Media ◽  
Ossicular Chain ◽  
Multivariable Logistic Regression Analysis ◽  
Canal Wall ◽  
Multivariable Logistic Regression ◽  
Hearing Recovery

Objective To explore the factors affecting postoperative hearing recovery in chronic otitis media (COM) patients, establish a clinical prediction model for hearing recovery, and verify the accuracy of the model. Methods Data of patients with COM who were admitted to our hospital between January 1, 2012 and September 30, 2020 were retrospectively analyzed. We collected data on relevant clinicopathological characteristics of patients. The patients were randomly divided into the development cohort and validation cohorts. A postoperative air-bone gap (ABG) ≤20 dB was defined as successful hearing recovery. Univariate and multivariable logistic regression analyses were used to investigate the association of several prognostic factors with hearing recovery. These factors were then used to establish a nomogram. The model was subjected to bootstrap internal validation and performance evaluation in terms of discrimination, calibration, and clinical validity. Results This study included 2146 patients with COM: the development cohort comprised 1610 patients (mean [standard deviation; SD] age, 44.1 [14.7] years; 733 men [45.5%]) and the validation cohort included 536 patients (mean [SD] age, 42.9 [14.4] years; 234 men [43.7%]). Multivariable logistic regression analysis showed that age, duration of onset, styles of surgery (tympanoplasty, canal wall up-CWU, or canal wall down-CWD), ossicular prosthesis, granulation or calcified blocks around the ossicular chain, ossicular chain integrity, duration of drilling, eustachian tube dysfunction, mixed hearing loss, semicircular canal fistula, and second surgery were associated with hearing recovery. A nomogram based on these variables was constructed. The area under the curve was 0.797 (95% confidence interval [CI], 0.778–0.812) in the development cohort and 0.798 (95% CI, 0.7605–0.8355) in the validation cohort. Conclusions This study demonstrated the various clinical factors correlated with hearing recovery in patients with COM. The nomogram developed with these data could provide personalized risk estimates of hearing recovery to enhance preoperative counseling and help to set realistic expectations in patients.

Audiometric correlations with pathologies of ossicular chain in 159 ears with chronic otitis media

2016 ◽  
Vol 41 (6) ◽  
pp. 817-821 ◽  
Author(s):  
A.E. Dinç ◽  
M. Damar ◽  
D. Erdem ◽  
S.Ş. Eliçora ◽  
İ. Akyıldız ◽  
...  
Keyword(s):  
Otitis Media ◽  
Chronic Otitis Media ◽  
Ossicular Chain

scholarly journals Ossicular chain defects in adults with chronic otitis media

2019 ◽  
Vol 23 (1) ◽  
Author(s):  
Arash bayat ◽  
Nader Saki. Soheila Nikakhlagh ◽  
Mohammad Amin Farshad ◽  
Mojtaba Lotfinia
Keyword(s):  
Otitis Media ◽  
Chronic Otitis Media ◽  
Ossicular Chain ◽  
Chain Defects

scholarly journals The effect of preserved stapedial superstructure on hearing improvement

2019 ◽  
Vol 73 (6) ◽  
pp. 1-5
Author(s):  
Aleksandra Boroń ◽  
Agnieszka Wiatr ◽  
Jacek Składzień ◽  
Maciej Wiatr
Keyword(s):  
Otitis Media ◽  
Chronic Otitis Media ◽  
Ossicular Chain ◽  
The Other ◽  
Middle Ear Surgery ◽  
Reconstruction Method ◽  
Hearing Improvement ◽  
Ear Surgery ◽  
Extent Of Damage

Introduction: Ossiculoplasty can be carried out in a number of ways, depending on the anatomical and functional conditions encountered during otosurgery and the experience of a given centre. The extent of damage to the ossicular chain determines the reconstruction method. Aim: The objective of the study was to analyse treatment effects in terms of postoperative hearing improvement in patients with chronic otitis media, with a particular emphasis on stapedial superstructure preservation. Material and method: The records of 294 consecutive patients undergoing their first ENT surgery due to chronic otitis media at the Department of Otolaryngology of Collegium Medicum, Jagiellonian University of Kraków in 2009–2013 were analysed. In order to assess the role of preserved stapedial superstructure, 96 patients were eligible for further analysis. Results: The analysis points to a significant hearing improvement after ossiculoplasty with the preserved stapedial superstructure as compared with the patients after footplate mobilisation. On the other hand, the research results point to significantly smaller hearing improvement in those patients, in whom only stapes was preserved, as compared with those, in whom a more extensive reconstruction of the ossicular chain was possible. Conclusions: The air-bone gap measured before otosurgery often fails to reflect the extent of abnormalities and cannot, therefore, be considered as the only prognostic factor for postoperative hearing improvement. Stapes preservation is crucial for hearing improvement after middle ear surgery.

Sign in / Sign up

Export Citation Format

Share Document