Impact of Donor Arterial Partial Pressure of Oxygen on Outcomes After Lung Transplantation in Adult Cystic Fibrosis Recipients

Lung ◽  
2016 ◽  
Vol 194 (4) ◽  
pp. 547-553 ◽  
Author(s):  
Don Hayes ◽  
Benjamin T. Kopp ◽  
Stephen E. Kirkby ◽  
Susan D. Reynolds ◽  
Heidi M. Mansour ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Transplantation ◽  
Partial Pressure ◽  
Partial Pressure Of Oxygen ◽  
Arterial Partial Pressure

scholarly journals Right-to-left shunt determination in dog lungs under inhalation anesthesia with rebreathing and non-rebreathing system

2006 ◽  
Vol 21 (6) ◽  
pp. 374-379 ◽  
Author(s):  
André Leguthe Rosa ◽  
Patrícia Cristina Azevedo Mota ◽  
Yara Marcondes Machado Castiglia
Keyword(s):  
Partial Pressure ◽  
Carbon Dioxide Partial Pressure ◽  
Partial Pressure Of Oxygen ◽  
Intrapulmonary Shunt ◽  
Inhalation Anesthesia ◽  
Arterial Partial Pressure ◽  
Venous Oxygen Saturation ◽  
Fraction Of Inspired Oxygen ◽  
Inspired Oxygen ◽  
Mixed Venous

PURPOSE: To investigatge right-to-left shunt determination in dog lungs under inhalantion anesthesia with non-rebreathing and rebreathing systems and fraction of inspired oxygen (F I O2) of 0.9 and 0.4, respectively. METHODS: Two groups of 10 dogs each under inhalation anesthesia with sevoflurane: GI in which it was utilized non-rebreathing semiclosed system and F I O2 = 0.9, and GII in which it was utilized rebreathing semiclosed system and F I O2 = 0.4. The study parameters were: heart rate, medium arterial pressure, right-to-left intrapulmonary shunt, hematocrit, hemoglobin, arterial partial pressure of oxygen, mixed venous partial pressure of oxygen, mixed venous oxygen saturation, arterial partial pressure of carbon dioxide, partial pressure of water in the alveoli. RESULTS: Shunt results were significantly different between the two groups - GI data were higher than GII in all the evaluated moments. Hence, the group with nonrebreathing (GI) developed a superior grade of intrapulmonary shunt when compared with the rebreathing group (GII). The partial pressure of water in the alveoli was significantly higher in GII. CONCLUSION: The inhalation anesthesia with non-rebreathing system and F I O2 = 0.9 developed a higher grade of intrapulmonary right-to-left shunt when compared with the rebreathing system and F I O2 = 0.4. The higher humidity in GII contributed to the result.

Changes inα-tocopherol and retinol levels during cardiopulmonary bypass correlate with maximal arterial partial pressure of oxygen

2007 ◽  
Vol 41 (9) ◽  
pp. 1061-1067 ◽  
Author(s):  
Irene Valle-Giner ◽  
Ezequiel Martí-Bonmatí ◽  
Amparo Alegría-Torán ◽  
Anastasio Montero ◽  
Esteban J. Morcillo
Keyword(s):  
Cardiopulmonary Bypass ◽  
Partial Pressure ◽  
Partial Pressure Of Oxygen ◽  
Arterial Partial Pressure

Decline in arterial partial pressure of oxygen after exercise: a surrogate marker of pulmonary vascular obstructive disease in patients with atrial septal defect and severe pulmonary hypertension

2011 ◽  
Vol 21 (3) ◽  
pp. 292-298 ◽  
Author(s):  
Srinivas Laksmivenkateshiah ◽  
Anil K. Singhi ◽  
Balu Vaidyanathan ◽  
Edwin Francis ◽  
Sundaram R. Karimassery ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Partial Pressure ◽  
Atrial Septal Defect ◽  
Pulmonary Vascular Resistance ◽  
Vascular Resistance ◽  
Septal Defect ◽  
Resistance Index ◽  
Partial Pressure Of Oxygen ◽  
Arterial Partial Pressure ◽  
Pulmonary Vascular Resistance Index

AbstractObjectivesTo examine the utility of decline in arterial partial pressure of oxygen after exercise as a marker of pulmonary vascular obstructive disease in patients with atrial septal defect and pulmonary hypertension.MethodsTreadmill exercise was performed in 18 patients with atrial septal defect and pulmonary hypertension. Arterial blood gas samples were obtained before and after peak exercise. A decline in the arterial pressure of oxygen of more than 10 millimetres of mercury after exercise was considered significant based on preliminary tests conducted on the controls. Cardiac catheterisation was performed in all patients and haemodynamic data sets were obtained on room air, oxygen, and a mixture of oxygen and nitric oxide (30–40 parts per million).ResultsThere were 10 patients who had more than a 10 millimetres of mercury drop in arterial partial pressure of oxygen after exercise and who had a basal pulmonary vascular resistance index of more than 7 Wood units per square metre. Out of eight patients who had less than a 10 millimetres of mercury drop in arterial partial pressure of oxygen after exercise, seven had a basal pulmonary vascular resistance index of less than 7 Wood units per square metre, p equals 0.0001. A decline in arterial partial pressure of oxygen of more than 10 millimetres of mercury predicted a basal pulmonary vascular resistance index of more than 7 Wood units per square metre with a specificity of 100% and a sensitivity of 90%.ConclusionsA decline in arterial partial pressure of oxygen following exercise appears to predict a high pulmonary vascular resistance index in patients with atrial septal defect and pulmonary hypertension. This test is a useful non-invasive marker of pulmonary vascular obstructive disease in this subset.

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