Glucose enhances rotavirus enterotoxin-induced intestinal chloride secretion

2017 ◽  
Vol 469 (9) ◽  
pp. 1093-1105 ◽  
Author(s):  
Liangjie Yin ◽  
Rejeesh Menon ◽  
Reshu Gupta ◽  
Lauren Vaught ◽  
Paul Okunieff ◽  
...  
Keyword(s):  
Chloride Secretion ◽  
Intestinal Chloride Secretion

Tin protoporphyrin induces intestinal chloride secretion by inducing light oxidation processes

2007 ◽  
Vol 292 (5) ◽  
pp. C1906-C1914 ◽  
Author(s):  
Aliye Uc ◽  
Krzysztof J. Reszka ◽  
Garry R. Buettner ◽  
John B. Stokes
Keyword(s):  
Short Circuit ◽  
Specific Inhibitor ◽  
Chloride Secretion ◽  
Epithelial Cell Line ◽  
Intestinal Epithelial ◽  
Paramagnetic Resonance ◽  
Ussing Chambers ◽  
Oxidative Processes ◽  
Tin Protoporphyrin ◽  
Intestinal Chloride Secretion

Heme induces Cl− secretion in intestinal epithelial cells, most likely via carbon monoxide (CO) generation. The major source of endogenous CO comes from the degradation of heme via heme oxygenase (HO). We hypothesized that an inhibitor of HO activity, tin protoporphyrin (SnPP), may inhibit the stimulatory effect of heme on Cl− secretion. To test this hypothesis, we treated an intestinal epithelial cell line (Caco-2 cells) with SnPP. In contrast to our expectations, Caco-2 cells treated with SnPP had an increase in their short-circuit currents ( Isc) in Ussing chambers. This effect was observed only when the system was exposed to ambient light. SnPP-induced Isc was caused by Cl− secretion because it was inhibited in Cl−-free medium, with ouabain or 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB). The Cl− secretion was not via activation of the CFTR, because a specific inhibitor had no effect. Likewise, inhibitors of adenylate cyclase and guanylate cyclase had no effect on the enhanced Isc. SnPP-induced Isc was inhibited by the antioxidant vitamins, α-tocopherol and ascorbic acid. Electron paramagnetic resonance experiments confirmed that oxidative reactions were initiated with light in cells loaded with SnPP. These data suggest that SnPP-induced effects may not be entirely due to the inhibition of HO activity but rather to light-induced oxidative processes. These novel effects of SnPP-photosensitized oxidation may also lead to a new understanding of how intestinal Cl− secretion can be regulated by the redox environment of the cell.

Inhibition of CFTR-mediated intestinal chloride secretion by a fungus-derived arthropsolide A: Mechanism of action and anti-diarrheal efficacy

2020 ◽  
Vol 885 ◽  
pp. 173393
Author(s):  
Nattaphong Akrimajirachoote ◽  
Saravut Satitsri ◽  
Ubonta Sommart ◽  
Vatcharin Rukachaisirikul ◽  
Chatchai Muanprasat
Keyword(s):  
Mechanism Of Action ◽  
Chloride Secretion ◽  
Intestinal Chloride Secretion

Dynamic role of microfilaments in intestinal chloride secretion

1994 ◽  
Vol 167 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Jeffrey B. Matthews ◽  
Christopher S. Awtrey ◽  
Kevin J. Tally ◽  
Jeremy A. Smith
Keyword(s):  
Chloride Secretion ◽  
Intestinal Chloride Secretion

Evidence for intestinal chloride secretion

2010 ◽  
Vol 95 (4) ◽  
pp. 471-478 ◽  
Author(s):  
Michael Murek ◽  
Sascha Kopic ◽  
John Geibel
Keyword(s):  
Chloride Secretion ◽  
Intestinal Chloride Secretion

scholarly journals Inhibition of cAMP-Activated Intestinal Chloride Secretion by Diclofenac: Cellular Mechanism and Potential Application in Cholera

2014 ◽  
Vol 8 (9) ◽  
pp. e3119 ◽  
Author(s):  
Pawin Pongkorpsakol ◽  
Nutthapoom Pathomthongtaweechai ◽  
Potjanee Srimanote ◽  
Sunhapas Soodvilai ◽  
Varanuj Chatsudthipong ◽  
...  
Keyword(s):  
Potential Application ◽  
Chloride Secretion ◽  
Cellular Mechanism ◽  
Intestinal Chloride Secretion

scholarly journals The role of epithelial P2Y2 and P2Y4 receptors in the regulation of intestinal chloride secretion

2005 ◽  
Vol 146 (3) ◽  
pp. 364-369 ◽  
Author(s):  
Esam Ghanem ◽  
Bernard Robaye ◽  
Teresinha Leal ◽  
Jens Leipziger ◽  
Willy Van Driessche ◽  
...  
Keyword(s):  
Chloride Secretion ◽  
Intestinal Chloride Secretion

scholarly journals Epac1 mediates protein kinase A–independent mechanism of forskolin-activated intestinal chloride secretion

2009 ◽  
Vol 187 (7) ◽  
pp. i18-i18
Author(s):  
Kazi Mirajul Hoque ◽  
Owen M. Woodward ◽  
Damian B. van Rossum ◽  
Nicholas C. Zachos ◽  
Linxi Chen ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Chloride Secretion ◽  
Independent Mechanism ◽  
Intestinal Chloride Secretion ◽  
Kinase A
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