scholarly journals Structural abnormalities in thalamo-prefrontal tracks revealed by high angular resolution diffusion imaging predict working memory scores in concussed children

2020 ◽  
Vol 225 (1) ◽  
pp. 441-459 ◽  
Author(s):  
Guido I. Guberman ◽  
Jean-Christophe Houde ◽  
Alain Ptito ◽  
Isabelle Gagnon ◽  
Maxime Descoteaux
Keyword(s):  
Working Memory ◽  
Angular Resolution ◽  
Diffusion Imaging ◽  
High Angular Resolution ◽  
Structural Abnormalities

Inference of multiple fiber orientations in high angular resolution diffusion imaging

2005 ◽  
Vol 54 (6) ◽  
pp. 1480-1489 ◽  
Author(s):  
Tim Hosey ◽  
Guy Williams ◽  
Richard Ansorge
Keyword(s):  
Angular Resolution ◽  
Diffusion Imaging ◽  
High Angular Resolution

scholarly journals Computational Representation of White Matter Fiber Orientations

2013 ◽  
Vol 2013 ◽  
pp. 1-12
Author(s):  
Adelino R. Ferreira da Silva
Keyword(s):  
White Matter ◽  
Angular Resolution ◽  
Diffusion Imaging ◽  
Real Data ◽  
Orientation Distribution ◽  
Directional Data ◽  
High Angular Resolution ◽  
Clustering Data ◽  
Von Mises ◽  
Computational Representation

We present a new methodology based on directional data clustering to represent white matter fiber orientations in magnetic resonance analyses for high angular resolution diffusion imaging. A probabilistic methodology is proposed for estimating intravoxel principal fiber directions, based on clustering directional data arising from orientation distribution function (ODF) profiles. ODF reconstructions are used to estimate intravoxel fiber directions using mixtures of von Mises-Fisher distributions. The method focuses on clustering data on the unit sphere, where complexity arises from representing ODF profiles as directional data. The proposed method is validated on synthetic simulations, as well as on a real data experiment. Based on experiments, we show that by clustering profile data using mixtures of von Mises-Fisher distributions it is possible to estimate multiple fiber configurations in a more robust manner than currently used approaches, without recourse to regularization or sharpening procedures. The method holds promise to support robust tractographic methodologies and to build realistic models of white matter tracts in the human brain.

scholarly journals In vivo characterization of the connectivity and subcomponents of the human globus pallidus

2015 ◽  
Author(s):  
Patrick Beukema ◽  
Timothy Verstynen ◽  
Fang-Cheng Yeh
Keyword(s):  
Angular Resolution ◽  
Diffusion Imaging ◽  
Orientation Distribution ◽  
High Angular Resolution ◽  
Fiber Direction ◽  
Degree Of Anisotropy ◽  
In Vivo Characterization ◽  
Diffusion Properties

Projections from the substantia nigra and striatum traverse through the pallidum on the way to their targets. To date, in vivo characterization of these pathways remains elusive. Here we used high angular resolution diffusion imaging (N=138) to study the characteristics and structural subcompartments of the human pallidum. Our results show that the diffusion orientation distribution at the pallidum is asymmetrically oriented in a dorsolateral direction, consistent with the orientation of underlying fiber systems. Furthermore, compared to the outer pallidal segment, the internal segment has more peaks in the orientation distribution function and stronger anisotropy in the primary fiber direction, consistent with known cellular differences between the underlying nuclei. These differences in orientation, complexity, and degree of anisotropy are sufficiently robust to automatically segment the pallidal nuclei using diffusion properties. Thus the gray matter diffusion signal can be useful as an in vivo measure of the collective nigrostriatal and striatonigral pathways.

scholarly journals Technical and functional validations of High Angular Resolution Diffusion Imaging (HARDI)-MR tractography in paediatric epilepsy patients

2013 ◽  
Vol 7 ◽  
Author(s):  
Barton Sarah ◽  
Yang Joseph ◽  
Maixner Wirginia ◽  
Harvey A. Simon ◽  
Freeman Jeremy ◽  
...  
Keyword(s):  
Angular Resolution ◽  
Diffusion Imaging ◽  
High Angular Resolution ◽  
Paediatric Epilepsy
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