scholarly journals EM modelling of arbitrary shaped dispersive chiral dielectric objects using a 3D leapfrog scheme on unstructured meshes

2020 ◽  
Author(s):  
A. Gansen ◽  
M. El Hachemi ◽  
S. Belouettar ◽  
O. Hassan ◽  
K. Morgan
Keyword(s):  
The Novel ◽  
Basic Scheme ◽  
Material Interfaces ◽  
Material Parameters ◽  
Yee Scheme ◽  
Leapfrog Scheme ◽  
The Stability ◽  
Dielectric Objects ◽  
Lossy Materials ◽  
Modelling Problems

Abstract The standard Yee FDTD algorithm is widely used in computational electromagnetics because of its simplicity and divergence free nature. A generalization of this classical scheme to 3D unstructured co-volume meshes is adopted, based on the use of a Delaunay primal mesh and its high quality Voronoi dual. This circumvents the problem of accuracy losses, which are normally associated with the use of a staircased representation of curved material interfaces in the standard Yee scheme. The procedure has been successfully employed for modelling problems involving both isotropic and anisotropic lossy materials. Here, we consider the novel extension of this approach to allow for the challenging modelling of chiral materials, where the material parameters are frequency dependent. To adequately model the dispersive behaviour, the Z-transform is employed, using second order Padé approximations to maintain the accuracy of the basic scheme. To validate the implementation, the numerical results produced are compared with available analytical solutions. The stability of the chiral algorithm is also studied.

STRUKTUR NARASI NOVEL CA BAU KAN, KARYA REMY SYLADO ANALISIS SEMIOTIK

2017 ◽  
Vol 4 (1) ◽  
pp. 70
Author(s):  
Sri Sabakti
Keyword(s):  
Narrative Structure ◽  
Literary Analysis ◽  
The Novel ◽  
Basic Scheme ◽  
Library Research ◽  
The Mean

This research is aimed to expose the narrative structure of the novel Ca Bau Kan by using semiotical theory. The source of the data is the novel Ca Bau kan written by Remy Silado and published by KPG, eight edition, 2004. The data is collected by doing the library research. The teory applied in this research is the emiotical theory, especially the literary analysis of Subur Laksono Wardoyo that the analysis of the text of prose can be applied by using three fases; the analysis of the basic scheme narrative, the analysis of mean signifier, and the analysis of syntagmatics and pragmatics. The result of this research showed that the narrative structure in the novel CBK that (1) the life of Tinung before being a ca bau kan, (2) the life of Tinung as a ca bau kan, and (3) the life of Tinung after not being a ca bau kan anymore. Based on the narrative structure, it was found that “ Love is only one. No measurement is needed” is the mean signifier and able to be clarified by the analysis of syntagmatics-paradigmatics based on the biner oposition of weak x strong.AbstrakPenelitian ini bertujuan mengungkapkan stuktur narasi dalam novel Ca Bau Kan (CBK) dengan menggunakan teori semiotika. Penelitian ini menggunakan sumber data novel CBK karya Remy Silado yang diterbitkan oleh KPG, cetakan kedelapan tahun 2004. Pengumpulan data dilaksanakan dengan teknik kepustakaan. Teori yang digunakan dalam penelitian ini adalah teori semiotika, khususnya analisis sastra menurut Subur Laksono Wardoyo bahwa analisis teks prosa dapat dilakukan melalui tiga tahap, yaitu: analisis skema naratif dasar, analisis signifier utama, dan analisis sintagmatik-paradigmatik. Hasil penelitian menggambarkan bahwa struktur narasi pada novel CBK adalah sebagai berikut: 1) kehidupan Tinung sebelum menjadi ca bau kan, 2) kehidupan Tinung sebagai ca bau kan, dan 3) kehidupan Tinung setelah tidak menjadi ca bau kan. Berdasarkan struktur narasi, maka didapatkan bahwa “Cinta cuma satu, kagak perlu takaran” merupakan penanda utama dan dapat diperjelas melalui analisis sintagmatik-paradigmatik yang didasarkan atas sebuah oposisi biner lemah x kuat.

Novel Nanolipoidal Systems for the Management of Skin Cancer

2020 ◽  
Vol 14 (2) ◽  
pp. 108-125
Author(s):  
Apoorva Singh ◽  
Nimisha
Keyword(s):  
Skin Cancer ◽  
Survival Rates ◽  
Cancer Therapeutics ◽  
The Body ◽  
Surgical Removal ◽  
The Novel ◽  
Skin Cancers ◽  
Recent Developments ◽  
Abnormal Cells ◽  
The Stability

: Skin cancer, among the various kinds of cancers, is a type that emerges from skin due to the growth of abnormal cells. These cells are capable of spreading and invading the other parts of the body. The occurrence of non-melanoma and melanoma, which are the major types of skin cancers, has increased over the past decades. Exposure to ultraviolet radiations (UV) is the main associative cause of skin cancer. UV exposure can inactivate tumor suppressor genes while activating various oncogenes. The conventional techniques like surgical removal, chemotherapy and radiation therapy lack the potential for targeting cancer cells and harm the normal cells. However, the novel therapeutics show promising improvements in the effectiveness of treatment, survival rates and better quality of life for patients. Different methodologies are involved in the skin cancer therapeutics for delivering the active ingredients to the target sites. Nano carriers are very efficient as they have the ability to improve the stability of drugs and further enhance their penetration into the tumor cells. The recent developments and research in nanotechnology have entitled several targeting and therapeutic agents to be incorporated into nanoparticles for an enhancive treatment of skin cancer. To protect the research works in the field of nanolipoidal systems various patents have been introduced. Some of the patents acknowledge responsive liposomes for specific targeting, nanocarriers for the delivery or co-delivery of chemotherapeutics, nucleic acids as well as photosensitizers. Further recent patents on the novel delivery systems have also been included here.

An effective 3D leapfrog scheme for electromagnetic modelling of arbitrary shaped dielectric objects using unstructured meshes

2015 ◽  
Vol 56 (6) ◽  
pp. 1023-1037 ◽  
Author(s):  
A. Gansen ◽  
M. El Hachemi ◽  
S. Belouettar ◽  
O. Hassan ◽  
K. Morgan
Keyword(s):  
Unstructured Meshes ◽  
Electromagnetic Modelling ◽  
Leapfrog Scheme ◽  
Dielectric Objects

Light-Induced Metastable Defects in a-Si:H: Towards an Understanding

1985 ◽  
Vol 49 ◽  
Author(s):  
Martin Stutzmann ◽  
Warren B. Jackson ◽  
Chuang Chuang Tsai
Keyword(s):  
Amorphous Silicon ◽  
Mechanical Stress ◽  
Hydrogenated Amorphous Silicon ◽  
Material Parameters ◽  
Kinetic Behaviour ◽  
Proposed Model ◽  
Special Cases ◽  
The Stability ◽  
Hydrogenated Amorphous

AbstractThe dependence of the creation and the annealing of metastable dangling bonds in hydrogenated amorphous silicon on various material parameters will be discussed in the context of a recently proposed model. After a brief review of the kinetic behaviour governing defect creation and annealing in undoped a- Si:H, a number of special cases will be analyzed: the influence of alloying with O, N, C, and Ge, changes introduced by doping and compensation, and the role of mechanical stress. Finally, possibilities to increase the stability of a-Si:H based devices will be examined.

Investigation of Thermochemical Hydrogen Production via the Novel Thermo-Mechanical Stabilized Iron Oxide-Zirconia Porous Structure

2013 ◽  
Author(s):  
Ayyoub M. Mehdizadeh ◽  
Kelvin Randhir ◽  
James F. Klausner ◽  
Nicholas AuYeung ◽  
Fotouh Al-Raqom ◽  
...  
Keyword(s):  
Hydrogen Production ◽  
Porous Structure ◽  
Chemical Reactivity ◽  
Thermal Reduction ◽  
The Novel ◽  
Concentrated Solar Energy ◽  
The Matrix ◽  
Unique Method ◽  
Laboratory Scale Reactor ◽  
The Stability

In this study we have developed a unique method for synthesizing very reactive water splitting materials that will remain stable at temperatures as high as 1450 °C to efficiently produce clean hydrogen from concentrated solar energy. The hydrogen production for a laboratory scale reactor using a “Thermo-mechanical Stabilized Porous Structure” (TSPS) is experimentally investigated for oxidation and thermal reduction temperatures of 1200 and 1450 °C, respectively. The stability and reactivity of a 10 g TSPS over many consecutive oxidation and thermal reduction cycles for different particle size ranges has been investigated. The novel thermo-mechanical stabilization exploits sintering and controls the geometry of the matrix of particles inside the structure in a favorable manner so that the chemical reactivity of the structure remains intact. The experimental results demonstrate that this structure yields peak hydrogen production rates of 1–2 cm3/(min.gFe3O4) during the oxidation step at 1200 °C and the 30 minute thermal reduction step at 1450 ° C without noticeable degradation over many consecutive cycles. The hydrogen production rate is one of the highest yet reported in the open literature for thermochemical looping processes using thermal reduction. This novel process has strong potential for developing an enabling technology for efficient and commercially viable solar fuel production.

scholarly journals Proteome Integral Stability Alteration assay dramatically increases throughput and sensitivity in profiling factor-induced proteome changes

2018 ◽  
Author(s):  
Massimiliano Gaetani ◽  
Pierre Sabatier ◽  
Amir Ata Saei ◽  
Christian Beusch ◽  
Zhe Yang ◽  
...  
Keyword(s):  
Chemical Biology ◽  
Living Cells ◽  
Parameter Variation ◽  
The Novel ◽  
Factor Intensity ◽  
Unusual Behavior ◽  
Analysis Scheme ◽  
The Stability ◽  
Proteome Changes ◽  
Integral Stability

Various factors, including drugs as well as non-molecular influences, induce alterations in the stability of proteins in cell lysates, living cells and organisms. These alterations can be probed by applying a stability-modifying agent, such as elevated temperature, to a varying degree. As a second dimension of variation, drug concentration or factor intensity can be used. However, the corresponding analysis scheme has a low throughput and high cost. Additionally, since traditional data analysis employs curve fitting, proteins with unusual behavior are frequently ignored. The novel Proteome Integral Stability Alteration (PISA) assay avoids these issues altogether, increasing the analysis throughput by one to two orders of magnitude for unlimited number of parameter variation points. The consumption of the compound and biological material decreases by the same factor. We envision widespread use of the PISA approach in chemical biology and drug development.

scholarly journals A Yeast-Based Functional Assay to Study Plant N-Degron – N-Recognin Interactions

2022 ◽  
Vol 12 ◽  
Author(s):  
Aida Kozlic ◽  
Nikola Winter ◽  
Theresia Telser ◽  
Jakob Reimann ◽  
Katrin Rose ◽  
...  
Keyword(s):  
Ubiquitin Proteasome System ◽  
Functional Assay ◽  
The Novel ◽  
In Planta ◽  
Amino Terminal ◽  
Weak Binding ◽  
Ubiquitin Conjugating Enzyme ◽  
Ubiquitin Proteasome ◽  
The Stability

The N-degron pathway is a branch of the ubiquitin-proteasome system where amino-terminal residues serve as degradation signals. In a synthetic biology approach, we expressed ubiquitin ligase PRT6 and ubiquitin conjugating enzyme 2 (AtUBC2) from Arabidopsis thaliana in a Saccharomyces cerevisiae strain with mutation in its endogenous N-degron pathway. The two enzymes re-constitute part of the plant N-degron pathway and were probed by monitoring the stability of co-expressed GFP-linked plant proteins starting with Arginine N-degrons. The novel assay allows for straightforward analysis, whereas in vitro interaction assays often do not allow detection of the weak binding of N-degron recognizing ubiquitin ligases to their substrates, and in planta testing is usually complex and time-consuming.

Biochemical and Biophysical characterization of the main protease, 3-chymotrypsin-like protease (3CLpro), from the novel coronavirus disease 19 (COVID-19)

2020 ◽  
Author(s):  
Juliana C. Ferreira ◽  
Wael M. Rabeh
Keyword(s):  
Antiviral Drug ◽  
Analytical Techniques ◽  
The Novel ◽  
Buffer Solution ◽  
Biophysical Characterization ◽  
Main Protease ◽  
Wide Ph Range ◽  
The Stability ◽  
Ph Range ◽  
Novel Coronavirus

Abstract Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is responsible for the novel coronavirus disease 2019 (COVID-19). An appealing antiviral drug target is the coronavirus 3C-like protease (3CLpro) that is responsible for the processing of the viral polyproteins and liberation of functional proteins essential for the maturation and infectivity of the virus. In this study, multiple thermal analytical techniques have been implemented to acquire the thermodynamic parameters of 3CLpro at different buffer conditions. 3CLpro exhibited relatively high thermodynamic stabilities over a wide pH range; however, the protease was found to be less stable in the presence of salts. Divalent metal cations reduced the thermodynamic stability of 3CLpro more than monovalent cations; however, altering the ionic strength of the buffer solution did not alter the stability of 3CLpro. Furthermore, the most stable thermal kinetic stability of 3CLpro was recorded at pH 7.5, with the highest enthalpy of activation calculated from the slope of Eyring plot. The biochemical and biophysical properties of 3CLpro explored here will improve the solubility and stability of 3CLpro for optimum conditions for the setup of an enzymatic assay for the screening of inhibitors to be used as lead candidates in the drug discovery and antiviral design for therapeutics against COVID-19.

Targeting complex plutonium oxides by combining crystal chemical reasoning with density-functional theory calculations: the quaternary plutonium oxide Cs2PuSi6O15

2020 ◽  
Vol 56 (66) ◽  
pp. 9501-9504
Author(s):  
Kristen A. Pace ◽  
Vladislav V. Klepov ◽  
Matthew S. Christian ◽  
Gregory Morrison ◽  
Travis K. Deason ◽  
...  
Keyword(s):  
Density Functional Theory ◽  
Crystal Growth ◽  
Dft Calculations ◽  
Density Functional ◽  
Density Functional Theory Calculations ◽  
Crystal Chemical ◽  
The Novel ◽  
Functional Theory ◽  
The Stability ◽  
Chemical Reasoning

The stability of the novel Pu(iv) silicate, Cs2PuSi6O15, was predicted from a combination of crystal chemical reasoning and DFT calculations and confirmed by its synthesis via flux crystal growth.

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