scholarly journals Physical therapy plus general practitioners’ care versus general practitioners’ care alone for sciatica: a randomised clinical trial with a 12-month follow-up

2008 ◽  
Vol 17 (4) ◽  
pp. 509-517 ◽  
Author(s):  
Pim A. J. Luijsterburg ◽  
Arianne P. Verhagen ◽  
Raymond W. J. G. Ostelo ◽  
Hans J. M. M. van den Hoogen ◽  
Wilco C. Peul ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Physical Therapy ◽  
General Practitioners ◽  
Randomised Clinical Trial

scholarly journals Effect of Vitamin D Supplementation on Faecal Microbiota: A Randomised Clinical Trial

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2888 ◽  
Author(s):  
Negar Naderpoor ◽  
Aya Mousa ◽  
Luisa Fernanda Gomez Arango ◽  
Helen L. Barrett ◽  
Marloes Dekker Nitert ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Vitamin D ◽  
Gut Microbiota ◽  
Randomised Clinical Trial ◽  
Vitamin D Supplementation ◽  
Faecal Microbiota ◽  
Lower Abundance ◽  
Α Diversity ◽  
Significant Difference

In animal studies, vitamin D supplementation has been shown to improve gut microbiota and intestinal inflammation. However, limited evidence exists on the effect of vitamin D supplementation on the human gut microbiota. We examined the effect of vitamin D supplementation on faecal microbiota in 26 vitamin D-deficient (25-hydroxyvitamin D (25(OH)D) ≤50 nmol/L), overweight or obese (BMI ≥25 kg/m2) otherwise healthy adults. Our study was ancillary to a community based double-blind randomised clinical trial, conducted between 2014 and 2016. The participants provided stool samples at baseline and after 100,000 international units (IU) loading dose of cholecalciferol followed by 4000 IU daily or matching placebo for 16 weeks. Faecal microbiota was analysed using 16S rRNA sequencing; V6–8 region. There was no significant difference in microbiome α-diversity between vitamin D and placebo groups at baseline and follow-up (all p > 0.05). In addition, no clustering was found based on vitamin D supplementation at follow-up (p = 0.3). However, there was a significant association between community composition and vitamin D supplementation at the genus level (p = 0.04). The vitamin D group had a higher abundance of genus Lachnospira, and lower abundance of genus Blautia (linear discriminate analysis >3.0). Moreover, individuals with 25(OH)D >75 nmol/L had a higher abundance of genus Coprococcus and lower abundance of genus Ruminococcus compared to those with 25(OH)D <50 nmol/L. Our findings suggest that vitamin D supplementation has some distinct effects on faecal microbiota. Future studies need to explore whether these effects would translate into improved clinical outcomes.

scholarly journals A Randomised Clinical Trial of a Meridian-Based Intervention for Food Cravings With Six-Month Follow-Up

2011 ◽  
Vol 28 (1) ◽  
pp. 1-16 ◽  
Author(s):  
Peta Stapleton ◽  
Terri Sheldon ◽  
Brett Porter ◽  
Jennifer Whitty
Keyword(s):  
Clinical Trial ◽  
Psychological Symptoms ◽  
Randomised Clinical Trial ◽  
Repeated Measure ◽  
Delayed Effect ◽  
Obese Adults ◽  
Food Cravings ◽  
Group Data ◽  
Post Test

AbstractThis randomised, clinical trial tested whether The Emotional Freedom Technique (EFT) reduced food cravings. This study involved 96 overweight or obese adults who were allocated to the EFT treatment or 4-week waitlist condition. Degree of food craving, perceived power of food, restraint capabilities and psychological symptoms were assessed pre- and post- a 4-week treatment program (mixed method ANOVA comparative analysis), and at 6-month follow-up (repeated measure ANOVA with group data collapsed). EFT was associated with a significantly greater improvement in food cravings, the subjective power of food and craving restraint than waitlist from pre- to immediately post-test (p< .05). Across collapsed groups, an improvement in food cravings and the subjective power of food after active EFT treatment was maintained at 6 months, and a delayed effect was seen for craving restraint. Although there was a significant reduction in measures of psychological distress immediately after treatment (p< .05), there was no between-group difference. These findings are consistent with the hypothesis that EFT can have an immediate effect on reducing food cravings and can result in maintaining reduced cravings over time.

scholarly journals Treatment of non-culprit lesions detected during primary PCI: long-term follow-up of a randomised clinical trial

2012 ◽  
Vol 20 (9) ◽  
pp. 347-353 ◽  
Author(s):  
A. Ghani ◽  
J-H. E. Dambrink ◽  
A. W. J. van ’t Hof ◽  
J. P. Ottervanger ◽  
A. T. M. Gosselink ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomised Clinical Trial ◽  
Primary Pci ◽  
Long Term Follow Up

scholarly journals Comparison between Autologous Blood and Fibrin Glue for Adhering Conjunctival Autografts after Pterygium Excision- A Randomised Clinical Trial

2021 ◽  
Author(s):  
Mona Sune ◽  
Pradeep Sune
Keyword(s):  
Clinical Trial ◽  
Fibrin Glue ◽  
Autologous Blood ◽  
Randomised Clinical Trial ◽  
Mild Degree ◽  
Group A ◽  
Pterygium Surgery ◽  
Pterygium Excision ◽  
Group B

Introduction: Fibrin glue is a biological tissue adhesive and acts on the principle of final stages of the coagulation cascade. The cost of commercially available products is very high and not affordable for the patients of low socio-economic strata. As an alternative, pterygium surgery was done using patient’s own blood to adhere the conjunctival autograft to scleral bed by the process of coagulation of fibrin from the oozing blood from the blood vessels under the flap. Aim: To compare autologous blood and fibrin glue for adhering conjunctival autografts after pterygium excision. Materials and Methods: It was a randomised clinical trial. Total 97 subjects with primary pterygium who visited the Ophthalmology Department were randomised into two groups. In group A (n=31), patients had undergone pterygium excision wherein conjunctival autograft was attached by fibrin glue. In group B (n=66) the graft was attached by autologous blood present on the scleral bed. Mean operative time for the procedures were compared. Follow- up was done for 12 months and all subjects were examined for postoperative pain, foreign body sensation, inflammation, graft stability and recurrence. Results: The mean age of patients in group A was 48.32±14.3 years (21-65 years), and in group B was 54.48±15.67 (23-74 years). Mean operating time in group A was 23.21±9.4 minutes and 13.7±4.3 minutes in group B, (p-value=0.001). Postoperative pain of mild degree was present in all the 31 (100%) subjects of group A. In group B, pain was absent in 32 (48.5%) and mild degree in 34 (51.5%) subjects. No recurrence was found in both the groups. Mean follow-up period was 11.4 months. Conclusion: This study concludes that autologous blood is a useful alternative method for graft attachment in pterygium surgery without the untoward complications related to fibrin glue.

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