The use of tranexamic acid to reduce blood loss in primary cementless total hip arthroplasty

2010 ◽  
Vol 21 (2) ◽  
pp. 101-104 ◽  
Author(s):  
Rajesh Malhotra ◽  
Vijay Kumar ◽  
Bhavuk Garg
Keyword(s):  
Total Hip Arthroplasty ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Hip Arthroplasty ◽  
Reduce Blood Loss ◽  
Total Hip ◽  
Cementless Total Hip Arthroplasty

The Effect of Tranexamic Acid on Reducing Blood Loss in Cementless Total Hip Arthroplasty Under Epidural Anesthesia

Orthopedics ◽  
2010 ◽  
Vol 33 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Seyyed Morteza Kazemi ◽  
Faramarz Mosaffa ◽  
Alireza Eajazi ◽  
Mohammad Kaffashi ◽  
Laleh Daftari Besheli ◽  
...  
Keyword(s):  
Total Hip Arthroplasty ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Hip Arthroplasty ◽  
Epidural Anesthesia ◽  
Total Hip ◽  
Cementless Total Hip Arthroplasty

scholarly journals Effects of Tranexamic Acid on Blood Loss during Total Hip Arthroplasty

2010 ◽  
Vol 18 (3) ◽  
pp. 282-286 ◽  
Author(s):  
Jagwant Singh ◽  
Moez S Ballal ◽  
P Mitchell ◽  
PG Denn
Keyword(s):  
Total Hip Arthroplasty ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Hip Arthroplasty ◽  
Total Hip

Effect of Multiple Doses of Oral Tranexamic Acid on Haemostasis and Inflammatory Reaction in Total Hip Arthroplasty: A Randomized Controlled Trial

2018 ◽  
Vol 119 (01) ◽  
pp. 092-103 ◽  
Author(s):  
Duan Wang ◽  
Yang Yang ◽  
Chuan He ◽  
Ze-Yu Luo ◽  
Fu-Xing Pei ◽  
...  
Keyword(s):  
Total Hip Arthroplasty ◽  
Blood Loss ◽  
Inflammatory Response ◽  
Tranexamic Acid ◽  
Hip Arthroplasty ◽  
Multiple Dose ◽  
Control Group ◽  
Total Hip ◽  
Estimated Blood Loss ◽  
Significant Difference

AbstractTranexamic acid (TXA) reduces surgical blood loss and alleviates inflammatory response in total hip arthroplasty. However, studies have not identified an optimal regimen. The objective of this study was to identify the most effective regimen of multiple-dose oral TXA in achieving maximum reduction of blood loss and inflammatory response based on pharmacokinetic recommendations. We prospectively studied four multiple-dose regimens (60 patients each) with control group (group A: matching placebo). The four multiple-dose regimens included: 2-g oral TXA 2 hours pre-operatively followed by 1-g oral TXA 3 hours post-operatively (group B), 2-g oral TXA followed by 1-g oral TXA 3 and 7 hours post-operatively (group C), 2-g oral TXA followed by 1-g oral TXA 3, 7 and 11 hours post-operatively (group D) and 2-g oral TXA followed by 1-g oral TXA 3, 7, 11 and 15 hours post-operatively (group E). The primary endpoint was estimated blood loss on post-operative day (POD) 3. Secondary endpoints were thromboelastographic parameters, inflammatory components, function recovery and adverse events. Groups D and E had significantly less blood loss on POD 3, with no significant difference between the two groups. Group E had the most prolonged haemostatic effect, and all thromboelastographic parameters remained within normal ranges. Group E had the lowest levels of inflammatory cytokines and the greatest range of motion. No thromboembolic complications were observed. The post-operative four-dose regimen brings about maximum efficacy in reducing blood loss, alleviating inflammatory response and improving analgaesia and immediate recovery.

An Aprotinin Containing Fibrin Sealant Does Not Reduce Blood Loss in Total Hip Arthroplasty

2017 ◽  
Vol 32 (11) ◽  
pp. 3445-3448 ◽  
Author(s):  
Sean M. Kearns ◽  
Hannah N. Kuhar ◽  
Daniel D. Bohl ◽  
Brett R. Levine
Keyword(s):  
Total Hip Arthroplasty ◽  
Blood Loss ◽  
Hip Arthroplasty ◽  
Fibrin Sealant ◽  
Reduce Blood Loss ◽  
Total Hip
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