Platelet-rich plasma versus exchange intramedullary nailing in treatment of long bone oligotrophic nonunions

2017 ◽  
Vol 28 (1) ◽  
pp. 131-137 ◽  
Author(s):  
Altuğ Duramaz ◽  
Hüseyin Tamer Ursavaş ◽  
Mustafa Gökhan Bilgili ◽  
Alkan Bayrak ◽  
Berhan Bayram ◽  
...  
Keyword(s):  
Intramedullary Nailing ◽  
Platelet Rich Plasma ◽  
Long Bone ◽  
Versus Exchange

scholarly journals Expandable intramedullary nailing and platelet rich plasma to treat long bone non-unions

2008 ◽  
Vol 9 (3) ◽  
pp. 129-134 ◽  
Author(s):  
Olimpio Galasso ◽  
Massimo Mariconda ◽  
Gaetano Romano ◽  
Nicola Capuano ◽  
Luigi Romano ◽  
...  
Keyword(s):  
Intramedullary Nailing ◽  
Platelet Rich Plasma ◽  
Long Bone

Comparison of Intramedullary Nailing and Plate Fixation for the Treatment of Nonunion of the Long Bone Fracture on Lower Extermities.

2000 ◽  
Vol 13 (2) ◽  
pp. 327
Author(s):  
Jong Seok Park ◽  
Jae Hoon Lee ◽  
Hee Kwon ◽  
Jae Eung Yoo ◽  
Joon Min Song ◽  
...  
Keyword(s):  
Intramedullary Nailing ◽  
Bone Fracture ◽  
Plate Fixation ◽  
Long Bone ◽  
Long Bone Fracture

scholarly journals Clinical and radiological evaluation of minimally invasive intramedullary fixation by titanium elastic nails in paediatric long bone fractures of lower limb: a prospective study

2019 ◽  
Vol 5 (5) ◽  
pp. 816
Author(s):  
A. Sandeep ◽  
Jayant Jain
Keyword(s):  
Intramedullary Nailing ◽  
Complication Rate ◽  
Bone Fractures ◽  
Full Range ◽  
Elastic Stable Intramedullary Nailing ◽  
Long Bone ◽  
Ankle Motion ◽  
Soft Tissue Envelope ◽  
Internal Support ◽  
Diaphyseal Fractures

<p class="abstract"><strong>Background:</strong> Elastic stable intramedullary nailing for the treatment of paediatric femur and tibial diaphyseal fractures was introduced by Prevot and colleagues in 1979. It follows three-point fixation principle that provides internal support in presence of cortical contact and an intact soft-tissue envelope. This technique has many advantages, including better reduction, dynamic axial stabilization, shorter hospitalization with early rehabilitation and low complication rate.</p><p class="abstract"><strong>Methods:</strong> This is a prospective observational study done at Kauvery Medical Centre, Trichy between May 2017 to May 2018 consisting of 39 children between age 5 to 16 years with diaphyseal fractures of femur and tibia. The fractures were treated by closed reduction and internal fixation with titanium elastic intramedullary nailing. The patients were evaluated clinically and radiologically and followed for an average of 6 months. Outcome was assessed using transcutaneous electrical nerve stimulation (TENS) scoring system used by Flynn et al.<strong></strong></p><p class="abstract"><strong>Results:</strong> Our series consisted of 39 patients (22 cases with fracture shaft of femur and 17 cases with fracture shaft of tibia), 33 males and only 6 females. Average time for radiological union was 9.89 weeks. All patients had full range of hip and ankle motion and 2 (5.1%) patients had mild restriction in knee flexion at 12 weeks.</p><p class="abstract"><strong>Conclusions:</strong> Elastic stable intramedullary nailing is an ideal method for treatment of paediatric femoral and tibial diaphyseal fractures due to lower complication rate and good functional outcome in comparison to other methods of treatment.</p>

scholarly journals Platelet-rich plasma decreases fibroblastic activity and woven bone formation with no significant immunohistochemical effect on long-bone healing: An experimental animal study with radiological outcomes

2018 ◽  
Vol 26 (3) ◽  
pp. 230949901880249 ◽  
Author(s):  
İbrahim Deniz Canbeyli ◽  
Rahmi Can Akgun ◽  
Orcun Sahin ◽  
Aysen Terzi ◽  
İsmail Cengiz Tuncay
Keyword(s):  
Bone Formation ◽  
Callus Formation ◽  
Platelet Rich Plasma ◽  
Long Bone ◽  
Proliferation Index ◽  
Fibroblast Proliferation ◽  
Ki 67 ◽  
Woven Bone ◽  
Group B ◽  
Mature Bone

Purpose: This study aimed to analyze the immunohistochemical effect of platelet-rich plasma (PRP) on healing of long-bone fractures in terms of bone morphogenetic protein-2 (BMP-2), vascular endothelial growth factor (VEGF), the Ki-67 proliferation index, and radiological and histological analyses. Methods: Sixteen adult rabbits, whose right femoral diaphysis was fractured and fixed with Kirschner wires, were randomly divided into two groups, control and PRP (groups A and B, respectively). PRP was given to group B at 1 week postoperatively, and all animals were euthanized after 12 weeks. Radiographic evaluations were performed periodically. Cortical callus formation, chondroid and woven bone area percentages, osteoblastic and fibroblastic activities, and mature bone formation were examined. The depths of BMP-2 and VEGF staining were measured. The Ki-67 proliferation index was also calculated. Results: The mean radiological union score of group B was significantly higher than that of group A. There were also statistically significant differences between groups A and B in terms of cortical callus formation, woven bone area percentage, fibroblast proliferation, and mature bone formation. Group B had significantly more cortical callus and mature bone formation with less woven bone and fibroblast proliferation. Immunohistochemical analysis revealed no statistically significant difference between the groups in terms of BMP-2 and VEGF staining and the Ki-67 index. Conclusions: PRP had no effect on BMP-2 or VEGF levels with no increase in the Ki-67 proliferation index, although its application had a positive effect on bone healing by increasing callus and mature bone formation with decreased woven bone and fibroblast proliferation.

Prognostic factors for surgical site infection following intramedullary nailing of diaphyseal fractures of the femur and tibia in adult patients at a tertiary hospital in Lusaka, Zambia

2021 ◽  
pp. 004947552110646
Author(s):  
Webster Musonda ◽  
Derek Freitas ◽  
Kaunda Yamba ◽  
William Jim Harrison ◽  
James Munthali
Keyword(s):  
Prognostic Factors ◽  
Surgical Site Infection ◽  
Intramedullary Nailing ◽  
Tertiary Hospital ◽  
Alternative Methods ◽  
Long Bone ◽  
Site Infection ◽  
Resource Setting ◽  
Early Return ◽  
Diaphyseal Fractures

Our study aimed to identify prognostic factors for surgical site infection following long bone fracture intramedullary nailing at a tertiary hospital in a low-resource setting. This was a longitudinal observational study involving 132 participants enrolled over a one-year period with femoral and tibial diaphyseal fractures scheduled for ORIF. Participant median age was 30 years (range: 26 – 42). The prevalence of surgical site infection was 16%. Male sex (AOR=0.26, 95% CI [0.70–0.98]; p = 0.047) was associated with lower odds of surgical site infection while associated non-musculoskeletal injuries were associated with higher odds of developing surgical site infection. Our study confirms a higher surgical site infection rate than normally accepted. However, intramedullary nailing in our setting is justified as it allows an early return to a pre-injury state. These interventions must be carried out in the best possible circumstances. Future studies could explore alternative methods of fracture fixation.

scholarly journals Systematic review on the outcomes of poller screw augmentation in intramedullary nailing of long bone fracture

2020 ◽  
Vol 5 (3) ◽  
pp. 189-203
Author(s):  
Maria Tennyson ◽  
Matija Krkovic ◽  
Mary Fortune ◽  
Ali Abdulkarim
Keyword(s):  
Systematic Review ◽  
Intramedullary Nailing ◽  
Long Bone ◽  
Screw Augmentation ◽  
Inverse Variance ◽  
Long Bone Fracture ◽  
Secondary Procedures ◽  
Im Nailing ◽  
Poller Screw ◽  
Coronal Malalignment

Various technical tips have been described on the placement of poller screws during intramedullary (IM) nailing; however studies reporting outcomes are limited. Overall there is no consistent conclusion about whether intramedullary nailing alone, or intramedullary nails augmented with poller screws is more advantageous. We conducted a systematic review of PubMed, EMBASE, and Cochrane databases. Seventy-five records were identified, of which 13 met our inclusion criteria. In a systematic review we asked: (1) What is the proportion of nonunions with poller screw usage? (2) What is the proportion of malalignment, infection and secondary surgical procedures with poller screw usage? The overall outcome proportion across the studies was computed using the inverse variance method for pooling. Thirteen studies with a total of 371 participants and 376 fractures were included. Mean follow-up time was 21.1 months. Mean age of included patients was 40.0 years. Seven studies had heterogenous populations of nonunions and acute fractures. Four studies included only acute fractures and two studies examined nonunions only. The results of the present systematic review show a low complication rate of IM nailing augmented with poller screws in terms of nonunion (4%, CI: 0.03–0.07), coronal plane malunion (5%, CI: 0.03–0.08), deep (5%, CI: 0.03–0.11) and superficial (6%, CI: 0.03–0.11) infections, and secondary procedures (8%, CI: 0.04–0.18). When compared with the existing literature our review suggests intramedullary nailing with poller screws has lower rates of nonunion and coronal malalignment when compared with nailing alone. Prospective randomized control trial is necessary to fully determine outcome benefits. Cite this article: EFORT Open Rev 2020;5:189-203. DOI: 10.1302/2058-5241.5.190040

SECONDARY INTRAMEDULLARY NAILING OF OPEN LOWER EXTREMITY LONG BONE FRACTURES AFTER EXTERNAL FIXATION

1993 ◽  
Vol 86 (Supplement) ◽  
pp. 80
Author(s):  
Thomas Calton ◽  
Stephen L. Henry ◽  
Zack Stearns ◽  
David Seligson
Keyword(s):  
Lower Extremity ◽  
External Fixation ◽  
Intramedullary Nailing ◽  
Bone Fractures ◽  
Long Bone ◽  
Long Bone Fractures

scholarly journals Effects of Calcium Sulfate Combined with Platelet-rich Plasma on Restoration of Long Bone Defect in Rabbits

2016 ◽  
Vol 129 (5) ◽  
pp. 557-561 ◽  
Author(s):  
Hua Chen ◽  
Xin-Ran Ji ◽  
Qun Zhang ◽  
Xue-Zhong Tian ◽  
Bo-Xun Zhang ◽  
...  
Keyword(s):  
Bone Defect ◽  
Calcium Sulfate ◽  
Platelet Rich Plasma ◽  
Long Bone ◽  
Long Bone Defect
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