An anisotropic stress-driven growth model for soft tissue based on Eulerian deformation tensor and growth potential

2021 ◽  
Author(s):  
Eun-Ho Lee
2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Cryslãine Flavia da Silva Rodrigues ◽  
André Luís Cabral de Lourenço

ABSTRACT The article aimed to forecast the Brazilian economy’s growth potential in the 2016-2025 period, assuming the absence of changes in industrial policy. It is based on a formal growth model constrained by the balance of payments (BOP) developed by the authors and disaggregated into three sectors (farming, industry, and services). All its parameters were econometrically estimated, including those of the world economy relevant to the Brazilian economy’s performance. Assuming that the current macroeconomic management “tripod” was maintained in the country, the basic interest rate and exchange rate policy were calibrated to generate the maximum growth rate allowed by the external constraint compatible with the maintenance of inflation in target each year. Forecasts were also made about the performance of the three sectors’ key variables, resulting from such calibration. Forecasted potential GDP and productivity growth were low (even by recent historical standards) and decreasing over time, with slower growth in the industrial sector than in other ones. The results revealed the critical importance of the industrial sector for such performance, suggesting that an efficient industrial policy could significantly increase the Brazilian economy’s growth potential.


2019 ◽  
Vol 97 (Supplement_2) ◽  
pp. 186-187
Author(s):  
Maciej M Misiura ◽  
Joao A N Filipe ◽  
Carrie L Walk ◽  
Ilias Kyriazakis

Abstract Key underlying assumptions of current pig growth models, developed in the context of nutritionally balanced feeds, may be invalid for pigs given inadequate dietary phosphorous (P). To account for pig performance on feeds of different P content, a dynamic, mechanistic growth model was developed where ingested P is allocated to either soft tissue or skeletal tissue. The following issues needed to be addressed: 1) potential impact of different dietary P concentrations on feed intake; 2) estimation of the whole-body protein (Pr):P relationship; 3) allocation of ingested P into different body tissues. Statistical analyses of the published literature data, utilising meta-regression indicated the following answers: 1) there was no compensatory feed consumption in pigs fed P-deficient diets (p > 0.05); 2) the whole-body Pr:P relationship was feed-dependent, i.e., body P was directly proportional to body Pr in pigs fed P-adequate diets but lower in pigs fed P-deficient diets; 3) P retention in the soft tissue was prioritised over P deposition in bone when the dietary P was low (p < 0.001). A growth model incorporating mechanisms based on the above data analyses suggests that pigs given P-limiting feeds attempt to maintain the same level of lean tissue retention attained with a P-balanced diet, but at the expense of reduced skeletal deposition. Specifically, bone P growth was reduced in relation to a balanced-diet for moderately-P-deficient diets, and static for severely-P-deficient diets. The overall average daily gain remained largely unaffected for moderately-P-deficient pigs. The present in-silico framework of P kinetics could be utilised to study the consequences of different P feeding strategies on animal growth and body composition, and to verify whether further reduction in dietary P requirements could be achieved with no loss in animal performance.


Author(s):  
D. C. Swartzendruber ◽  
Norma L. Idoyaga-Vargas

The radionuclide gallium-67 (67Ga) localizes preferentially but not specifically in many human and experimental soft-tissue tumors. Because of this localization, 67Ga is used in clinical trials to detect humar. cancers by external scintiscanning methods. However, the fact that 67Ga does not localize specifically in tumors requires for its eventual clinical usefulness a fuller understanding of the mechanisms that control its deposition in both malignant and normal cells. We have previously reported that 67Ga localizes in lysosomal-like bodies, notably, although not exclusively, in macrophages of the spocytaneous AKR thymoma. Further studies on the uptake of 67Ga by macrophages are needed to determine whether there are factors related to malignancy that might alter the localization of 67Ga in these cells and thus provide clues to discovering the mechanism of 67Ga localization in tumor tissue.


Author(s):  
J. P. Brunschwig ◽  
R. M. McCombs ◽  
R. Mirkovic ◽  
M. Benyesh-Melnick

A new virus, established as a member of the herpesvirus group by electron microscopy, was isolated from spontaneously degenerating cell cultures derived from the kidneys and lungs of two normal tree shrews. The virus was found to replicate best in cells derived from the homologous species. The cells used were a tree shrew cell line, T-23, which was derived from a spontaneous soft tissue sarcoma. The virus did not multiply or did so poorly for a limited number of passages in human, monkey, rodent, rabbit or chick embryo cells. In the T-23 cells, the virus behaved as members of the subgroup B of herpesvirus, in that the virus remained primarily cell associated.


Sign in / Sign up

Export Citation Format

Share Document