Local bone metabolism during the consolidation process of spinal interbody fusion

2021 ◽  
Author(s):  
Arjan C. Y. Loenen ◽  
Marloes J. M. Peters ◽  
Roel Wierts ◽  
Raymond T. J. Bevers ◽  
Lodewijk W. van Rhijn ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Interbody Fusion ◽  
Consolidation Process ◽  
Local Bone

scholarly journals Hydroxyapatite/collagen composite graft for posterior lumbar interbody fusion: a comparison with local bone graft

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Toshitaka Yoshii ◽  
Motonori Hashimoto ◽  
Satoru Egawa ◽  
Takashi Hirai ◽  
Hiroyuki Inose ◽  
...  
Keyword(s):  
Bone Graft ◽  
Interbody Fusion ◽  
Pedicle Screws ◽  
Posterior Lumbar Interbody Fusion ◽  
Incomplete Fusion ◽  
Complete Fusion ◽  
Spinal Diseases ◽  
Titanium Cage ◽  
Local Bone ◽  
Autologous Bone

Abstract Background Autologous bone has been used for posterior lumbar intervertebral fusion (PLIF). However, harvesting autologous bone graft is associated with donor site complications. We previously developed a hydroxyapatite/collagen (HAp/Col) composite as an osteoconductive artificial bone, characterized by having a highly porous structure with sponge‐like elasticity. This study aims to investigate the effectiveness of HAp/Col composite with bone marrow aspirate (BMA) as a graft substitute in PLIF for the treatment of lumbar spinal diseases. Methods This study prospectively investigated patients who received one-level PLIF. For the interbody fusion, two titanium cages were inserted. On the one side of interbody space, HAp/Col composite incorporated with BMA filling the titanium cage was grafted. On the other side, local bone graft (LBG) harvested during decompressive laminotomy was grafted and then one-level instrumentation using pedicle screws was performed. The target levels were at L2/3 in 2 cases, L3/4 in 3 cases, L4/5 in 36 cases, and L5/S in 5 cases. We evaluated clinical symptoms and radiological outcomes of 46 patients and compared the fusion status of HAp/Col composite with that of LBG. Results The 1-year postoperative CT evaluation demonstrated that, in the HAp/Col, a complete fusion was observed in 38 patients (82.6%), whereas in the LBG, a complete fusion was observed in 35 patients (76.1%). There were no statistical differences between the HAp/Col and LBG. In the HAp/Col, incomplete fusion was observed in five patients (10.9%) and non-fusion in two patients (4.3%), and in the LBG, incomplete fusion was observed in nine patients (19.6%) and non-fusion in two patients (4.3%). At 2 years after the surgery, complete fusion increased to 44 patients (95.7%) in the HAp/Col and 41 patients (89.1%) in the LBG. There were no significant differences in the clinical scores for lumbar spine between patients with fusion and non-fusion. Conclusions The HAp/Col composite with BMA in the titanium cage can be effectively used as an alternative to conventional autologous LBG for intervertebral spinal fusion. Trial registration University hospital Medical Information Network, UMIN000045010, July 30th, 2021, Retrospectively registered, https://www.umin.ac.jp/english/.

scholarly journals The efficacy of porous hydroxyapatite bone chip as an extender of local bone graft in posterior lumbar interbody fusion

2011 ◽  
Vol 21 (7) ◽  
pp. 1324-1330 ◽  
Author(s):  
Hyoungmin Kim ◽  
Choon-Ki Lee ◽  
Jin-Sup Yeom ◽  
Jae-Hyup Lee ◽  
Ki-Ho Lee ◽  
...  
Keyword(s):  
Bone Graft ◽  
Interbody Fusion ◽  
Posterior Lumbar Interbody Fusion ◽  
Lumbar Interbody Fusion ◽  
Porous Hydroxyapatite ◽  
Bone Chip ◽  
Local Bone

Incidence of microbiological contamination of local bone autograft used in posterior lumbar interbody fusion and its association with postoperative spinal infection

2016 ◽  
Vol 24 (1) ◽  
pp. 20-24 ◽  
Author(s):  
Chong-Suh Lee ◽  
Kyung-Chung Kang ◽  
Sung-Soo Chung ◽  
Ki-Tack Kim ◽  
Seong-Kee Shin
Keyword(s):  
Interbody Fusion ◽  
Posterior Lumbar Interbody Fusion ◽  
Positive Culture ◽  
Spinal Infection ◽  
Contamination Rate ◽  
Lumbar Interbody Fusion ◽  
Microbiological Culture ◽  
Local Bone ◽  
Bone Autograft ◽  
Spinal Infections

OBJECT The aim of this study was to examine the results of microbiological cultures from local bone autografts used in posterior lumbar interbody fusion (PLIF) and to identify their association with postoperative spinal infection. METHODS The authors retrospectively evaluated cases involving 328 patients who had no previous spinal surgeries and underwent PLIF for degenerative diseases with a minimum 1-year follow-up. Local bone was obtained during laminectomy, and microbiological culture was performed immediately prior to bone grafting. The associations between culture results from local bone autografts and postoperative spinal infections were evaluated. RESULTS The contamination rate of local bone was 4.3% (14 of 328 cases). Coagulase-negative Staphylococcus (29%) was the most common contaminant isolated, followed by Streptococcus species and methicillin-sensitive Staphylococcus aureus. Of 14 patients with positive culture results, 5 (35.7%) had postoperative spinal infections and were treated with intravenous antibiotics for a minimum of 4 weeks. One of these 5 patients also underwent reoperation for debridement during this 4-week period. Regardless of the microbiological culture results, the infection rate after PLIF with local bone autograft was 2.4% (8 of 328 cases), with 5 (62.5%) of 8 patients showing positive results on autograft culture. CONCLUSIONS The incidence of contamination of local bone autograft during PLIF was considerable, and positive culture results were significantly associated with postoperative spinal infection. Special attention focused on the preparation of local bone for autograft and its microbiological culture will be helpful for the control of postoperative spinal infection.

Bone Metabolism in the Healing Process of Lumbar Interbody Fusion-Temporal changes of bone turnover markers-

Spine ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Ryota Hyakkan ◽  
Masahiro Kanayama ◽  
Masahiko Takahata ◽  
Fumihiro Oha ◽  
Tomoyuki Hashimoto ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Metabolism ◽  
Bone Turnover Markers ◽  
Interbody Fusion ◽  
Healing Process ◽  
Temporal Changes ◽  
Lumbar Interbody Fusion ◽  
Turnover Markers
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