Electrochemical study of the anomalous salt extraction from water to a polar organic solvent

2020 ◽  
Vol 24 (9) ◽  
pp. 2173-2174
Author(s):  
Vladimír Mareček ◽  
Zdeněk Samec
Keyword(s):  
Organic Solvent ◽  
Electrochemical Study ◽  
Salt Extraction ◽  
Polar Organic Solvent

Micellization in Water-Polar Organic Solvent Binary Mixtures

2011 ◽  
Vol 1 (4) ◽  
pp. 352-368
Author(s):  
Maria Luisa Moya ◽  
Maria del Mar Graciani/snm ◽  
> ◽  
Victoria Isabel Martin
Keyword(s):  
Organic Solvent ◽  
Binary Mixtures ◽  
Polar Organic Solvent

scholarly journals Coordination-Driven Poly[2]Pseudorotaxanes in Highly Polar Organic Solvent

2020 ◽  
Vol 8 ◽  
Author(s):  
Hang Su ◽  
Wei Chen ◽  
Liang Li ◽  
Bin Li ◽  
Zhi-Yuan Zhang ◽  
...  
Keyword(s):  
Organic Solvent ◽  
Polar Organic Solvent

scholarly journals Efficient Biocatalytic Preparation of Optically Pure (R)-1-[4-(Trifluoromethyl)phenyl]ethanol by Recombinant Whole-Cell-Mediated Reduction

Catalysts ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 391 ◽  
Author(s):  
Ying Chen ◽  
Nana Xia ◽  
Yuewang Liu ◽  
Pu Wang
Keyword(s):  
Organic Solvent ◽  
Asymmetric Reduction ◽  
Enantiomeric Excess ◽  
Aqueous System ◽  
Cell Membrane Permeability ◽  
Buffer Solution ◽  
Preparative Scale ◽  
Buffer Medium ◽  
Polar Organic Solvent ◽  
Optically Pure

(R)-1-[4-(Trifluoromethyl)phenyl]ethanol is an important pharmaceutical intermediate of a chemokine CCR5 antagonist. In the present study, a bioprocess for the asymmetric reduction of 4-(trifluoromethyl)acetophenone to (R)-1-[4-(trifluoromethyl)phenyl]ethanol was developed by recombinant Escherichia coli cells with excellent enantioselectivity. In order to overcome the conversion limitation performed in the conventional buffer medium resulting from poor solubility of non-natural substrate, we subsequently established a polar organic solvent-aqueous medium to improve the efficacy. Isopropanol was selected as the most suitable cosolvent candidate, based on the investigation on a substrate solubility test and cell membrane permeability assay in different organic solvent-buffer media. Under the optimum conditions, the preparative-scale asymmetric reduction generated a 99.1% yield with >99.9% product enantiomeric excess (ee) in a 15% (v/v) isopropanol proportion, at 100 mM of 4-(trifluoromethyl)acetophenone within 3 h. Compared to bioconversion in the buffer medium, the developed isopropanol-aqueous system enhanced the substrate concentration by 2-fold with a remarkably improved yield (from 62.5% to 99.1%), and shortened the reaction time by 21 h. Our study gave the first example for a highly enantioselective production of (R)-1-[4-(trifluoromethyl)phenyl]ethanol by a biological method, and the bioreduction of 4-(trifluoromethyl)acetophenone in a polar organic solvent-aqueous system was more efficient than that in the buffer solution only. This process is also scalable and has potential in application.

Role of water in the mechanism of the salt extraction to the organic solvent

2019 ◽  
Vol 306 ◽  
pp. 541-548 ◽  
Author(s):  
Karel Holub ◽  
Zdeněk Samec ◽  
Vladimír Mareček
Keyword(s):  
Organic Solvent ◽  
Salt Extraction

Polar Organic Solvent-Tolerant Perovskite Nanocrystals Permanently Ligated with Polymer Hairs via Star-like Molecular Bottlebrush Trilobe Nanoreactors

Nano Letters ◽  
2019 ◽  
Vol 19 (12) ◽  
pp. 9019-9028 ◽  
Author(s):  
Yijiang Liu ◽  
Zewei Wang ◽  
Shuang Liang ◽  
Zili Li ◽  
Mingyue Zhang ◽  
...  
Keyword(s):  
Organic Solvent ◽  
Perovskite Nanocrystals ◽  
Organic Solvent Tolerant ◽  
Polar Organic Solvent ◽  
Solvent Tolerant

Reactivity of a glucose oxidase electrode in a polar organic solvent

1994 ◽  
Vol 31 (1) ◽  
pp. 19 ◽  
Author(s):  
Emmanuel I. Iwuoha ◽  
Malcolm R. Smyth
Keyword(s):  
Organic Solvent ◽  
Glucose Oxidase ◽  
Polar Organic Solvent
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