scholarly journals Whole-genome sequencing revealed independent emergence of vancomycin-resistant Enterococcus faecium causing sequential outbreaks over 3 years in a tertiary care hospital

2019 ◽  
Vol 38 (6) ◽  
pp. 1163-1170 ◽  
Author(s):  
Mohamed H. H. Abdelbary ◽  
Laurence Senn ◽  
Gilbert Greub ◽  
Gregory Chaillou ◽  
Estelle Moulin ◽  
...  
Keyword(s):  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Enterococcus Faecium ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Whole Genome ◽  
Care Hospital ◽  
Vancomycin Resistant Enterococcus ◽  
Vancomycin Resistant

scholarly journals Emergence of an Australian-like pstS-null vancomycin resistant Enterococcus faecium clone in Scotland

2017 ◽  
Author(s):  
Kimon Lemonidis ◽  
Talal S. Salih ◽  
Stephanie J. Dancer ◽  
Iain S. Hunter ◽  
Nicholas P. Tucker
Keyword(s):  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Enterococcus Faecium ◽  
Sequence Type ◽  
Whole Genome ◽  
Vancomycin Resistant Enterococcus ◽  
Phylogenetic Comparison ◽  
Vancomycin Resistant ◽  
The Uk ◽  
Increased Susceptibility

AbstractMulti-locus sequencing typing (MLST) is widely used to monitor the phylogeny of microbial outbreaks. However, several strains of vancomycin-resistant Enterococcus faecium (VREfm) with a missing MLST locus (pstS) have recently emerged in Australia, with a few cases also reported in England. Here, we identified similarly distinct strains circulating in two closely located hospitals in Scotland. Whole genome sequencing of five VREfm strains isolated from these hospitals identified four pstS-null strains across both hospitals, while the fifth was of a multi-locus sequence type (ST) 262, which is the first documented in the UK. All five Scottish isolates had an insertion in the tetM gene, which is associated with increased susceptibility to tetracyclines, providing no other tetracycline-resistant gene is present. Such an insertion, which encompasses a dfrG gene and two currently uncharacterised genes, was additionally identified in all tested VanA-type pstS-null VREfm strains (5 English and 18 Australian). Phylogenetic comparison with other VREfm genomes indicates that the four pstS-null Scottish isolates sequenced in this study are more closely related to pstS-null strains from Australia rather than the English pstS-null isolates. Given how rapidly such pstS-null strains have expanded in Australia, the emergence of this clone in Scotland raises concerns for a potential outbreak.

scholarly journals Emergence of Vancomycin-Resistant Enterococcus faecium at an Australian Hospital: A Whole Genome Sequencing Analysis

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Kelvin W. C. Leong ◽  
Louise A. Cooley ◽  
Tara L. Anderson ◽  
Sanjay S. Gautam ◽  
Belinda McEwan ◽  
...  
Keyword(s):  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Enterococcus Faecium ◽  
Whole Genome ◽  
Sequencing Analysis ◽  
Vancomycin Resistant Enterococcus ◽  
Vancomycin Resistant ◽  
Australian Hospital

Emergence of vancomycin-resistant Enterococcus faecium at a tertiary care hospital in Karachi, Pakistan

2002 ◽  
Vol 52 (4) ◽  
pp. 292-296 ◽  
Author(s):  
E. Khan ◽  
A. Sarwari ◽  
R. Hasan ◽  
S. Ghori ◽  
I. Babar ◽  
...  
Keyword(s):  
Enterococcus Faecium ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Vancomycin Resistant Enterococcus ◽  
Vancomycin Resistant
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