Risk factors for the development of degenerative cervical myelopathy: a review of the literature

2021 ◽  
Author(s):  
Guillaume Baucher ◽  
Jelena Taskovic ◽  
Lucas Troude ◽  
Granit Molliqaj ◽  
Aria Nouri ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cervical Myelopathy ◽  
Review Of The Literature ◽  
Degenerative Cervical Myelopathy

312 Risk Factors and Clinical Outcomes of Dysphagia After Anterior Cervical Surgery in Patients With Degenerative Cervical Myelopathy

Neurosurgery ◽  
2016 ◽  
Vol 63 ◽  
pp. 190 ◽  
Author(s):  
Lindsay Tetreault ◽  
Narihito Nagoshi ◽  
Hiroaki Nakashima ◽  
Paul M. Arnold ◽  
Giuseppe Barbagallo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Outcomes ◽  
Cervical Myelopathy ◽  
Cervical Surgery ◽  
Anterior Cervical Surgery ◽  
Degenerative Cervical Myelopathy

Risk Factors for and Clinical Outcomes of Dysphagia After Anterior Cervical Surgery for Degenerative Cervical Myelopathy

2017 ◽  
Vol 99 (13) ◽  
pp. 1069-1077 ◽  
Author(s):  
Narihito Nagoshi ◽  
Lindsay Tetreault ◽  
Hiroaki Nakashima ◽  
Paul M. Arnold ◽  
Giuseppe Barbagallo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Outcomes ◽  
Cervical Myelopathy ◽  
Cervical Surgery ◽  
Anterior Cervical Surgery ◽  
Degenerative Cervical Myelopathy

scholarly journals Analysis of the Incidence and Risk factors of Postoperative Delirium in Patients with Degenerative Cervical Myelopathy

2020 ◽  
Author(s):  
Seok Woo Kim ◽  
Jeong Hwan Lee ◽  
Min Uk Lee ◽  
Hyung Min Lee ◽  
Seung Hun Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Multivariate Analysis ◽  
Cervical Myelopathy ◽  
Potassium Level ◽  
Sodium Level ◽  
Postoperative Delirium ◽  
Significant Risk ◽  
The Other ◽  
High Potassium ◽  
Degenerative Cervical Myelopathy

Abstract Delirium is one of the most common postoperative complications in surgical procedures. Postoperative delirium (POD) may affect normal recovery and outcomes after surgery. Degenerative Cervical myelopathy (DCM), a disease that progresses with age, usually associated with neurological symptoms. This study is designed to analyze the incidence and risk factors that cause post-operative delirium in DCM. The incidence and risk factors of delirium were analyzed in 148 patients aged 60 years or older who underwent surgery for DCM. Among the 148 patients who underwent surgery, 78 received laminoplasty, of whom 19 patients (24%) experienced delirium; the other 70 patients underwent ACDF, of whom five patients (7.1%) experienced delirium. The occurrence of POD in the laminoplasty group was 4.18 times higher than that in the ACDF group. Age, and sodium level were found to be significant risk factors for all 148 patients in a multivariate analysis. In the laminoplasty group, age, and high potassium level were meaningful risk factors in multiple regression analysis. Risk factors that affect the POD were not analyzed in ACDF due to the low n(=5). This study shows that the incidence and risk factors for POD can vary depending on the surgical method employed in patients with DCM.

scholarly journals Spine Treatment Appraisal Report (STAR): Does Riluzole Improve Outcomes in Patients Undergoing Decompression Surgery for Degenerative Cervical Myelopathy?

2021 ◽  
pp. 219256822199740
Author(s):  
Joseph R. Dettori
Keyword(s):  
Cervical Myelopathy ◽  
Decompressive Surgery ◽  
Decompression Surgery ◽  
Phase 3 ◽  
Double Blind ◽  
Safety And Efficacy ◽  
Double Blind Placebo ◽  
Degenerative Cervical Myelopathy

Fehlings MG, Badhiwala JH, Ahn H, et al. Safety and efficacy of riluzole in patients undergoing decompressive surgery for degenerative cervical myelopathy (CSM-Protect): a multicentre, double-blind, placebo-controlled, randomised, phase 3 trial. Lancet Neurol. 2020.

scholarly journals Degenerative Cervical Myelopathy: Insights into Its Pathobiology and Molecular Mechanisms

2021 ◽  
Vol 10 (6) ◽  
pp. 1214
Author(s):  
Ji Tu ◽  
Jose Vargas Castillo ◽  
Abhirup Das ◽  
Ashish D. Diwan
Keyword(s):  
Cervical Myelopathy ◽  
Molecular Mechanisms ◽  
Current Knowledge ◽  
Imaging Techniques ◽  
Disease Process ◽  
Classification Systems ◽  
Molecular Features ◽  
Formidable Challenge ◽  
Long Term Treatment ◽  
Degenerative Cervical Myelopathy

Degenerative cervical myelopathy (DCM), earlier referred to as cervical spondylotic myelopathy (CSM), is the most common and serious neurological disorder in the elderly population caused by chronic progressive compression or irritation of the spinal cord in the neck. The clinical features of DCM include localised neck pain and functional impairment of motor function in the arms, fingers and hands. If left untreated, this can lead to significant and permanent nerve damage including paralysis and death. Despite recent advancements in understanding the DCM pathology, prognosis remains poor and little is known about the molecular mechanisms underlying its pathogenesis. Moreover, there is scant evidence for the best treatment suitable for DCM patients. Decompressive surgery remains the most effective long-term treatment for this pathology, although the decision of when to perform such a procedure remains challenging. Given the fact that the aged population in the world is continuously increasing, DCM is posing a formidable challenge that needs urgent attention. Here, in this comprehensive review, we discuss the current knowledge of DCM pathology, including epidemiology, diagnosis, natural history, pathophysiology, risk factors, molecular features and treatment options. In addition to describing different scoring and classification systems used by clinicians in diagnosing DCM, we also highlight how advanced imaging techniques are being used to study the disease process. Last but not the least, we discuss several molecular underpinnings of DCM aetiology, including the cells involved and the pathways and molecules that are hallmarks of this disease.

scholarly journals Development of a validated search filter for Ovid Embase for degenerative cervical myelopathy

2021 ◽  
Author(s):  
Maaz A. Khan ◽  
Oliver M. Mowforth ◽  
Isla Kuhn ◽  
Mark R. N. Kotter ◽  
Benjamin M. Davies
Keyword(s):  
Cervical Myelopathy ◽  
Search Filter ◽  
Degenerative Cervical Myelopathy

scholarly journals Perioperative Complications of Surgery for Degenerative Cervical Myelopathy: A Comparison Between 3 Procedures

2021 ◽  
pp. 219256822199830
Author(s):  
Mohamed Kamal Mesregah ◽  
Blake Formanek ◽  
John C. Liu ◽  
Zorica Buser ◽  
Jeffrey C. Wang
Keyword(s):  
Propensity Score ◽  
Cervical Myelopathy ◽  
Perioperative Complications ◽  
International Classification Of Diseases ◽  
Significance Level ◽  
Chi Squared ◽  
Retrospective Comparative Study ◽  
Posterior Laminectomy ◽  
Degenerative Cervical Myelopathy ◽  
New Onset

Study Design: Retrospective comparative study. Objectives: To compare the perioperative complications of propensity score-matched cohorts of patients with degenerative cervical myelopathy (DCM), who were treated with anterior cervical discectomy and fusion (ACDF), posterior laminectomy with fusion, or laminoplasty. Methods: The Humana PearlDiver Patient Record Database was queried using the International Classification of Diseases (ICD-9 and ICD-10) and the Current Procedural Terminology (CPT) codes. Propensity score-matched analysis was done using multiple Chi-squared tests with Bonferroni correction of the significance level. Results: Cohorts of 11,790 patients who had ACDF, 2,257 patients who had posterior laminectomy with fusion, and 477 patients who had laminoplasty, were identified. After propensity score matching, all the 3 groups included 464 patients. The incidence of dysphagia increased significantly following ACDF compared to laminoplasty, P < 0.001, and in laminectomy with fusion compared to laminoplasty, P < 0.001. The incidence of new-onset cervicalgia was higher in ACDF compared to laminoplasty, P = 0.005, and in laminectomy with fusion compared to laminoplasty, P = 0.004. The incidence of limb paralysis increased significantly in laminectomy with fusion compared to ACDF, P = 0.002. The revision rate at 1 year increased significantly in laminectomy with fusion compared to laminoplasty, P < 0.001, and in ACDF compared to laminoplasty, P < 0.001. Conclusions: The incidence of dysphagia following laminectomy with fusion was not different compared to ACDF. Postoperative new-onset cervicalgia and revisions were least common in laminoplasty. The highest rate of postoperative limb paralysis was noticed in laminectomy with fusion.

Current surgical practice for multi-level degenerative cervical myelopathy: Findings from an international survey of spinal surgeons

2021 ◽  
Vol 87 ◽  
pp. 84-88
Author(s):  
Benjamin M. Davies ◽  
Jibin J. Francis ◽  
Max B. Butler ◽  
Oliver Mowforth ◽  
Edward Goacher ◽  
...  
Keyword(s):  
Cervical Myelopathy ◽  
International Survey ◽  
Surgical Practice ◽  
Multi Level ◽  
Degenerative Cervical Myelopathy

Degenerative cervical myelopathy

2021 ◽  
Author(s):  
L. Marie-Hardy ◽  
H. Pascal-Moussellard
Keyword(s):  
Cervical Myelopathy ◽  
Degenerative Cervical Myelopathy
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