scholarly journals Botulinum toxin: could it be an effective treatment for chronic tension-type headache?

2008 ◽  
Vol 10 (1) ◽  
pp. 27-34 ◽  
Author(s):  
Sherif M. Hamdy ◽  
Hatem Samir ◽  
M. El-Sayed ◽  
Nermin Adel ◽  
Rasha Hasan
Keyword(s):  
Botulinum Toxin ◽  
Effective Treatment ◽  
Tension Type Headache ◽  
Chronic Tension Type Headache ◽  
Type Headache

scholarly journals Botulinum Toxin Type A in the Prophylactic Treatment of Chronic Tension-Type Headache: A Multicentre, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study

Cephalalgia ◽  
2006 ◽  
Vol 26 (7) ◽  
pp. 790-800 ◽  
Author(s):  
SD Silberstein ◽  
H Göbel ◽  
R Jensen ◽  
AH Elkind ◽  
R DeGryse ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Primary Endpoint ◽  
Botulinum Toxin Type A ◽  
Tension Headache ◽  
Type A ◽  
Botulinum Toxin Type ◽  
Tension Type Headache ◽  
Chronic Tension Type Headache ◽  
Significant Difference ◽  
Type Headache

We studied the safety and efficacy of 0 U, 50 U, 100 U, 150 U (five sites), 86 Usub and 100 Usub (three sites) botulinum toxin type A (BoNTA; BOTOX®; Allergan, Inc., Irvine, CA, USA) for the prophylaxis of chronic tension-type headache (CTTH). Three hundred patients (62.3± female; mean age 42.6 years) enrolled. For the primary endpoint, the mean change from baseline in the number of TTH-free days per month, there was no statistically significant difference between placebo and four BoNTA groups, but a significant difference favouring placebo vs. BoNTA 150 was observed (4.5 vs. 2.8 tension headache-free days/month; P = 0.007). All treatment groups improved at day 60. Although efficacy was not demonstrated for the primary endpoint, at day 90, more patients in three BoNTA groups had ≥50± decrease in tension headache days than did placebo ( P ≤ 0.024). Most treatment-related adverse events were mild or moderate, and transient. BoNTA was safe and well-tolerated in the study.

Prophylactic treatment of chronic tension-type headache using botulinum toxin type A

1999 ◽  
Vol 6 ◽  
pp. s99-s102 ◽  
Author(s):  
Johan A. Smuts ◽  
Malcolm K. Baker ◽  
H. Magdalena Smuts ◽  
J. M. Rheta Stassen ◽  
Elsabe Rossouw ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Prophylactic Treatment ◽  
Botulinum Toxin Type A ◽  
Type A ◽  
Botulinum Toxin Type ◽  
Tension Type Headache ◽  
Chronic Tension Type Headache ◽  
Type Headache
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