scholarly journals Comprehensive registry of esophageal cancer in Japan, 2014

Esophagus ◽  
2021 ◽  
Author(s):  
Masayuki Watanabe ◽  
Yasushi Toh ◽  
Ryu Ishihara ◽  
Koji Kono ◽  
Hisahiro Matsubara ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Tnm Classification ◽  
Survival Rates ◽  
Cancer Control ◽  
Cancer Staging ◽  
Web Based ◽  
7Th Edition ◽  
Japanese Classification ◽  
Supraclavicular Lymph Node Metastasis ◽  
Radiotherapy Alone

Abstract Background The registration committee for esophageal cancer in the Japan Esophageal Society (JES) has collected the patients' characteristics, treatment, and outcomes annually. Methods We analyzed the data of patients who had visited the participating hospitals in 2014. We collected the data with a web-based data collection system using the National Clinical Database. We used the Japanese Classification of Esophageal Cancer 10th edition by JES and the TNM classification 7th edition by the Union of International Cancer Control (UICC) for cancer staging. Results A total of 9026 cases were registered from 344 institutions in Japan. Squamous cell carcinoma and adenocarcinoma accounted for 87.9% and 7.1%, respectively. The 5-year survival rates of patients treated using endoscopic resection, concurrent chemoradiotherapy, radiotherapy alone, and esophagectomy were 87.1%, 33.7%, 25.3%, and 59.3%, respectively. Esophagectomy was performed in 5204 cases. Concerning the approach used for esophagectomy, 48.1% of the cases were treated thoracoscopically. The operative mortality (within 30 days after surgery) was 0.75%, and the hospital mortality was 2.0%. The survival curves showed an excellent discriminatory ability both in the clinical and pathologic stages by the JES system. The survival of pStage IV was better than IIIC in the UICC system, because pStage IV included the patients with supraclavicular lymph-node metastasis (M1 LYM). Conclusion We hope that this report contributes to improving all aspects of diagnosing and treating esophageal cancer in Japan.

scholarly journals Comprehensive registry of esophageal cancer in Japan, 2013

Esophagus ◽  
2020 ◽  
Author(s):  
Masayuki Watanabe ◽  
◽  
Yuji Tachimori ◽  
Tsuneo Oyama ◽  
Yasushi Toh ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Data Collection ◽  
Tnm Classification ◽  
Survival Rates ◽  
Cancer Staging ◽  
Web Based ◽  
Electronic Submission ◽  
Japanese Classification ◽  
Japan Esophageal Society ◽  
Radiotherapy Alone

Abstract Background Esophageal cancer is the eighth most common cause of cancer mortality in Japan. More than 11,000 people had died from esophageal cancer in 2018. The Japan Esophageal Society has collected the data on patients' characteristics, performed treatment, and outcomes annually. Methods We analyzed the data of patients who had first visited the participating hospitals in 2013. In 2019, the data collection method was changed from an electronic submission to a web-based data collection using the National Clinical Database (NCD). Japanese Classification of Esophageal Cancer 10th by the Japan Esophageal Society (JES) and UICC TNM Classification 7th were used for cancer staging Results A total of 8019 cases were registered from 334 institutions in Japan. Squamous cell carcinoma and adenocarcinoma accounted for 87.8% and 6.3%, respectively. The 5-year survival rates of patients treated using endoscopic resection, concurrent chemoradiotherapy, radiotherapy alone, or esophagectomy were 88.3%, 32.4%, 24.4%, and 59.3%, respectively. Esophagectomy was performed in 4910 cases. The operative and the hospital mortality rates were 0.77% and 1.98%, respectively. The survival curves showed a good discriminatory ability both in the clinical and pathologic stages by the JES system. The 5-year survival rate of patients with pStage IV in the UICC classification that included patients with supraclavicular node metastasis was better than that of patients with pStage IVb in JES classification. Conclusion We hope this report contributes to improving all aspects of the diagnosis and treatment of esophageal cancer in Japan.

Multimodality treatment for esophageal cancer in Turkey: A single center experience.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e15507-e15507
Author(s):  
Umut Demirci ◽  
Fatma Bugdayci Basal ◽  
Ferit Aslan ◽  
Erkan Erdur ◽  
Ayse Demirci ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Tnm Classification ◽  
Locally Advanced ◽  
Survival Rates ◽  
Neoadjuvant Chemoradiotherapy ◽  
Multimodality Treatment ◽  
Single Center Experience ◽  
Stage 4 ◽  
Stage 1 ◽  
Upper Third

e15507 Background: Esophagus cancer is an important cause of cancer-related deaths in Turkey as well as in the world. In our study, clinicopathological features and survival results of patients treated for esophageal cancer were presented. Methods: This study retrospectively reviewed esophageal squamous cell carcinoma (SCC) and adenocarcinoma (ADC) patients who were admitted to our center, between 2012 and 2016. Results: A total of 82 patients (56 males) with a median age of 56 years were evaluated. Seventy-one (87%) patients were diagnosed with SCC, 10 (12%) with ADC, 1 with adenosquamous carcinoma. All ADC patients were HER2 negative. The localization of tumors; lower third (55%), middle third (27%) and upper third (18%) of the esophagus. Prior to surgery, neoadjuvant chemoradiotherapy (CRT) was administered in 21 patients (26%); 10 of them receiving carboplatin and paclitaxel (CP), and 11 receiving cisplatin and 5-FU (CF). TNM classification of operated patients were as follows; Stage 1 (n = 5), stage 2 (n = 10), stage 3 (n = 8) and stage 4 (n = 1). Adjuvant chemotherapy (CF) was administered in the other 6 (7%) patients. Definitive CRT was given in 36 patients (44%), with CF being administered in 32 patients, and CP therapy in 4 patients. There were 19 patients (23%) with metastatic diagnosis and 13 of whom were treated with CF, and 4 with docetaxel-cisplatin-5FU combination. With median follow up of 21 months, median overall survival (OS) and time to progression (TTP) were 24 and 17 months, respectively. The median OS and TTP of patients with metastatic disease were 14 and th 9 months, respectively. The median OS and TTP of the patients who underwent surgery were 45 and 34 months, respectively. Conclusions: Our findings in this study regarding the rate of histology, the percentages of patients with metastatic vs. locally advanced disease, and survival rates were similar to the literature.

scholarly journals A proposal for uniformity in classification of lymph node stations in esophageal cancer

2021 ◽  
Author(s):  
N Schuring ◽  
S Matsuda ◽  
E R C Hagens ◽  
J Sano ◽  
S Mayanagi ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Cancer Control ◽  
Cancer Staging ◽  
Data Interpretation ◽  
Classification Systems ◽  
Significant Heterogeneity ◽  
Node Metastases

Summary The 11th edition of the “Japanese Classification of Esophageal Cancer” by the Japan Esophageal Society (JES) and the 8th edition of the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) “Cancer Staging Manual” are two separate classification systems both widely used for the clinical and pathological staging of esophageal cancer. Furthermore, the lymph node stations from these classification systems are combined for research purposes in the multinational TIGER study, which investigates the distribution pattern of lymph node metastases. The existing classification systems greatly differ with regard to number, location and anatomical boundaries of locoregional lymph node stations. The differences in these classifications cause significant heterogeneity in studies on lymph node metastases in esophageal cancer. This makes data interpretation difficult and comparison of studies challenging. In this article, we propose a match for these two commonly used classification systems and additionally for the TIGER study classification, in order to be able to compare results of studies and exchange knowledge and to make steps towards one global uniform classification system for all patients with esophageal cancer.

scholarly journals Closing the Gap on the Availability of Cancer Staging Information for Healthcare Providers in the Global Cancer Community: Development of a Multilingual Cancer Staging Video Series

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 173s-173s
Author(s):  
F.Y. Moraes ◽  
M. Giuliani ◽  
N.K. Quartey ◽  
J. Cardozo ◽  
N. Icliates ◽  
...  
Keyword(s):  
Web Sites ◽  
Cancer Education ◽  
Average Length ◽  
Tnm Classification ◽  
Healthcare Providers ◽  
Cancer Control ◽  
Cancer Staging ◽  
Video Production ◽  
Accurate Information ◽  
Cancer Stage

Background and context: Tumor, Node, Metastases (TNM) classification system provide valuable measures to researchers in facilitating the understanding of disparities in outcomes and allowing for the comparison of these outcomes over time. There is a lack of multimodal formats for disseminating comprehensive information and education about cancer stage to the global cancer community. To address this gap, the Departments of Radiation Oncology and Cancer Education at the Princess Margaret Cancer Centre (PM) (Toronto, Canada) in collaboration with The Union for International Cancer Control (UICC) envisioned the development of a cancer staging video series. Aim: To provide current and accurate information on cancer staging to healthcare professionals and stakeholders for global cancer control. Strategy/Tactics: The Cancer Education program worked with experts in the field of cancer staging to develop 8 videos (average length 4 min) to provide information to the global cancer community about existing information on key issues with cancer staging and how to properly stage patients using the TNM classification. Videos include references to current research and examples of staging across various cancers to illustrate and reinforce the importance of cancer staging. Script development involved defining key messages, refining learning objectives and breaking up information to ensure the content is digestible and easy to understand. Prior to video production, draft scripts were reviewed by international collaborators for completeness of information and accuracy of content. Videos contain appropriate text on screen to reinforce key messages and include a narrated voiceover to orient the learner. To expand the global reach, trained faculties translated the English videos and scripts, into the 5 official United Nations languages: Arabic, Chinese, French, Russian and Spanish. Program/Policy process: Videos in the cancer staging series include: The Importance of Cancer Staging; What is Cancer Stage; General Rules for Cancer Staging; Cancer Staging Examples; Staging Terminology; Importance of a Common Stage Language; Why Stage Language Changes; Essential TNM. Videos will be made available on UICC and PM Web sites (free of charge and globally advertised). Outcomes: The video series will increase education and awareness on the importance of a unified approach to cancer staging among the larger community and have the aim to empower the community on how to access cancer and define prognosis, treatment and or trial eligibility. What was learned: The development and promotion of the cancer staging video series was a meaningful, collaborative and challenging activity. It was learned that educational videos need to be well-designed and simple to provide axiomatic information on cancer stating to the global cancer control community.

scholarly journals Persistent Tracheostomy after Organ Preservation Protocol in Patients Treated for Larynx and Hypopharynx Cancer

2017 ◽  
Vol 21 (04) ◽  
pp. 377-381 ◽  
Author(s):  
Carlos Chiesa Estomba ◽  
Frank Betances Reinoso ◽  
Virginia Martinez Villasmil ◽  
Maria González Cortés ◽  
Carmelo Santidrian Hidalgo
Keyword(s):  
Quality Of Life ◽  
Laryngeal Carcinoma ◽  
Survival Rates ◽  
Treatment Protocol ◽  
Cancer Control ◽  
Tertiary Hospital ◽  
Hypopharyngeal Cancer ◽  
7Th Edition

Introduction Squamous cell carcinoma of the larynx is currently the second most common malignancy of the airway after lung cancer, and hypopharyngeal cancer accounts for fewer than 5% of head and neck cancers. The nonsurgical options for patients with this disease are related to significant long-term toxicities and the need for persistent tracheostomy, which adversely affects the quality of life of these patients. Objective To evaluate the need for tracheostomy, and the influence of this in the overall and specific survival rates of patients diagnosed with all stages of laryngeal carcinoma treated by chemoradiotherapy. Methods A retrospective study of patients diagnosed with laryngeal carcinoma was performed according to the criteria of the Union for International Cancer Control (UICC) and the American Joint Committee on Cancer (AJCC) 7th edition, in a tertiary hospital. Results A total of 21 patients were evaluated, 8 patients required a tracheotomy (31%) during the treatment protocol, 7 (35%) men and 1 (100%) women. According to subsite 4/4 patient with glottis cancer (p ≤ 0.001), 2/10 patients with supra glottis cancer and 2/7 patients with hypopharyngeal cancer. During follow up, just in 1 patient was possible to close the tracheostomy. Conclusion Persistent tracheostomy dependence after primary chemoradiation increases significantly the morbidity, and decreases the quality of life of those patients. Patients with glottis cancer are prone to need a tracheostomy, but no statistical difference regarding the oncological stage and the need for a tracheostomy were detected. A more thorough selection of the patients is needed to improve the quality of life and reduce permanent tracheostomy dependence.

A review of head and neck cancer staging system in the TNM classification of malignant tumors (eighth edition)

2019 ◽  
Vol 49 (7) ◽  
pp. 589-595 ◽  
Author(s):  
◽  
Nobuya Monden ◽  
Takahiro Asakage ◽  
Naomi Kiyota ◽  
Akihiro Homma ◽  
...  
Keyword(s):  
Head And Neck ◽  
Malignant Tumors ◽  
Tnm Classification ◽  
Cancer Control ◽  
Cancer Staging ◽  
Unknown Primary ◽  
Oropharyngeal Carcinoma ◽  
Depth Of Invasion ◽  
Eighth Edition

Abstract A number of major modifications were made to the classification of head and neck carcinomas in the eighth edition of the American Joint Committee on Cancer, Cancer Staging Manual and Union for International Cancer Control TNM classification of Malignant Tumors. These modifications were aimed at improving the prognosis prediction accuracy of the system. In this article, we review the new edition of the TNM classification system. Among the several changes in the new system, a separate algorithm for p16-positive oropharyngeal carcinoma was included, as were new chapters on ‘Head and Neck Skin Carcinoma’ and ‘Unknown Primary Carcinoma—Cervical Nodes.’ Changes to Tumor (T) classification were made by introducing the depth of invasion of oral carcinoma, whereas changes to Node (N) classification were made by adding extra-nodal extension. It is believed that these changes will help improve the accuracy of the system in the prediction of prognosis. However, it is necessary to verify their validity through further clinical research.

Evaluation of the seventh TNM classification system in patients with esophageal cancer receiving chemoradiotherapy.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 83-83
Author(s):  
M. Nomura ◽  
T. Kodaira ◽  
A. Mizota ◽  
C. Kondoh ◽  
K. Shitara ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Classification System ◽  
Tnm Classification ◽  
Stage Iv ◽  
Staging System ◽  
Tnm Staging ◽  
Cancer Site ◽  
Prognostic Impact ◽  
7Th Edition ◽  
Prognostic Group

83 Background: The new 7th edition of the TNM classification system is based on pathologic data of esophageal cancer underwent surgery alone. No report is available on the prognostic evaluation of the new staging system in patients treated with chemoradiotherapy (CRT). The objective of this study was to evaluate the prognostic impact of the 7th edition of the TNM staging system in esophageal cancer patients treated with CRT. Methods: A retrospective review was performed of 301 consecutive patients who met the following inclusion criteria: (1) squamous cell carcinoma of thoracic esophagus; (2) total radiation dose ≥ 50 Gy; (3) concomitant chemotherapy consisting of 5-fluolouracil and platinum; (4) no previous thoracic radiotherapy or surgery. We compared the prognostic impact of the 6th and 7th editions of the TNM staging systems. Also, we compared the prognostic impact of stage group and prognostic group, which was newly defined in the 7th edition. Survival analysis was performed by using log-rank and Cox regression testing. Results: Patients with stage I/II/III/IV were 52/42/54/153 and 57/46/128/70 according to 6th and 7th edition, respectively. Eighty-four patients were shifted to a lower stage in 7th edition compared with 6th edition, and most of these were from stage IV to III (n = 74). There were significant differences among stages I to III (p < 0.01, respectively) according to each edition. However, 7th edition poorly distinguishes between stages III and IV (p = 0.43). The survival curve of stage IV (lymph) almost completely overlapped with stage III (p = 0.69), although there were significant differences between stages IV (lymph) and IV (organ) (p = 0.04). Among the factors included in prognostic group in 7th edition, the histological grade and cancer site had no significant influence on patient survival, and T factor was only independent prognostic factors in multivariate analysis (p < 0.01). Conclusions: Our study suggested several pitfalls in 7th TNM classification as prognostic factor in patients who received CRT. No significant financial relationships to disclose.

Changes in the 7th Edition of the AJCC TNM Classification and Recommendations for Pathologic Analysis of Lacrimal Gland Tumors

2009 ◽  
Vol 133 (8) ◽  
pp. 1268-1271 ◽  
Author(s):  
Jack Rootman ◽  
Valerie A. White
Keyword(s):  
Salivary Gland ◽  
Recent Work ◽  
Lacrimal Gland ◽  
Tnm Classification ◽  
Staging System ◽  
Cancer Staging ◽  
7Th Edition ◽  
Data Points ◽  
Pathologic Analysis

Abstract In our recent work to update the American Joint Committee on Cancer's AJCC Cancer Staging Manual, we brought the staging system in line with that of salivary gland malignancies to better describe the range of these tumors. In addition, we have suggested that information be collected on biomarkers and clinical and histologic data points. This revised staging, along with careful histologic analysis and patient follow-up, may provide information that helps develop more targeted management for these lesions.

scholarly journals Updates in Staging and Reporting of Genitourinary Malignancies

2020 ◽  
Vol 144 (3) ◽  
pp. 305-319 ◽  
Author(s):  
Kristine M. Cornejo ◽  
Travis Rice-Stitt ◽  
Chin-Lee Wu
Keyword(s):  
Tnm Classification ◽  
Staging System ◽  
Cancer Staging ◽  
Classification Systems ◽  
Tumor Node Metastasis ◽  
7Th Edition ◽  
Pathologic Staging ◽  
Ajcc Staging ◽  
8Th Edition ◽  
Made In

Context.— The 8th edition of the American Joint Committee on Cancer (AJCC) staging manual changed the tumor, node, metastasis (TNM) classification systems of genitourinary malignancies in 2017. However, some of the changes appear not well appreciated or recognized by practicing pathologists. Objective.— To review the major changes compared with the 7th edition in cancers of the prostate, penis, testis, bladder, urethra, renal pelvis/ureter, and kidney and discuss the challenges that pathologists may encounter. Data Sources.— Peer-reviewed publications and the 8th and 7th editions of the AJCC Cancer Staging Manual. Conclusions.— This article summarizes the updated staging of genitourinary malignancies, specifically highlighting changes from the 7th edition that are relevant to the pathologic staging system. Pathologists should be aware of the updates made in hopes of providing clarification and the remaining diagnostic challenges associated with these changes.

Sign in / Sign up

Export Citation Format

Share Document