Enhancing droplet transition capabilities using sloped microfluidic channel geometry for stable droplet operation

2020 ◽  
Vol 22 (1) ◽  
Author(s):  
Jose A. Wippold ◽  
Can Huang ◽  
Dimitra Stratis-Cullum ◽  
Arum Han
Keyword(s):  
Microfluidic Channel ◽  
Channel Geometry ◽  
Droplet Transition

Effects of microfluidic channel geometry on leukocyte rolling assays

2012 ◽  
Vol 15 (1) ◽  
pp. 183-193 ◽  
Author(s):  
Phillip A. Coghill ◽  
Erin K. Kesselhuth ◽  
Eddie A. Shimp ◽  
Damir B. Khismatullin ◽  
David W. Schmidtke
Keyword(s):  
Microfluidic Channel ◽  
Leukocyte Rolling ◽  
Channel Geometry

Generative design of microfluidic channel geometry using evolutionary approach

2021 ◽  
Author(s):  
Nikolay O. Nikitin ◽  
Alexander Hvatov ◽  
Iana S. Polonskaia ◽  
Anna V. Kalyuzhnaya ◽  
Georgii V. Grigorev ◽  
...  
Keyword(s):  
Microfluidic Channel ◽  
Evolutionary Approach ◽  
Generative Design ◽  
Channel Geometry

scholarly journals Effect of Channel Geometry on Ionic Current Signal of a Bridge Circuit Based Microfluidic Channel

2018 ◽  
Vol 47 (3) ◽  
pp. 350-353 ◽  
Author(s):  
Hirotoshi Yasaki ◽  
Takao Yasui ◽  
Takeshi Yanagida ◽  
Noritada Kaji ◽  
Masaki Kanai ◽  
...  
Keyword(s):  
Bridge Circuit ◽  
Ionic Current ◽  
Microfluidic Channel ◽  
Current Signal ◽  
Channel Geometry

Improved micro-impedance spectroscopy to determine cell barrier properties

2020 ◽  
Vol 4 (3) ◽  
pp. 150-155 ◽  
Author(s):  
Md. Mehadi Hasan Sohag ◽  
Olivier Nicoud ◽  
Racha Amine ◽  
Abir Khalil-Mgharbel ◽  
Jean-Pierre Alcaraz ◽  
...  
Keyword(s):  
Impedance Spectroscopy ◽  
Epithelial Cells ◽  
Lipid Bilayers ◽  
Cultured Cells ◽  
Cell Model ◽  
Measurement Techniques ◽  
Cell Monolayer ◽  
Microfluidic Channel ◽  
Small Surface ◽  
Resistance Pathway

AbstractThe goal of this study was to determine whether the Tethapod system, which was designed to determine the impedance properties of lipid bilayers, could be used for cell culture in order to utilise micro-impedance spectroscopy to examine further biological applications. To that purpose we have used normal epithelial cells from kidney (RPTEC) and a kidney cancer cell model (786-O). We demonstrate that the Tethapod system is compatible with the culture of 10,000 cells seeded to grow on a small area gold measurement electrode for several days without affecting the cell viability. Furthermore, the range of frequencies for EIS measurements were tuned to examine easily the characteristics of the cell monolayer. We demonstrate significant differences in the paracellular resistance pathway between normal and cancer kidney epithelial cells. Thus, we conclude that this device has advantages for the study of cultured cells that include (i) the configuration of measurement and reference electrodes across a microfluidic channel, and (ii) the small surface area of 6 parallel measurement electrodes (2.1 mm2) integrated in a microfluidic system. These characteristics might improve micro-impedance spectroscopy measurement techniques to provide a simple tool for further studies in the field of the patho-physiology of biological barriers.

scholarly journals Differential Sorting of Microparticles Using Spiral Microchannels with Elliptic Configurations

Micromachines ◽  
2020 ◽  
Vol 11 (4) ◽  
pp. 412
Author(s):  
Kaan Erdem ◽  
Vahid Ebrahimpour Ahmadi ◽  
Ali Kosar ◽  
Lütfullah Kuddusi
Keyword(s):  
Cell Sorting ◽  
Microfluidic Channel ◽  
Major Axis ◽  
Label Free ◽  
Flow Rates ◽  
Inertial Focusing ◽  
Size Dependent ◽  
Curved Channels ◽  
Aspect Ratios ◽  
Dependent Cell

Label-free, size-dependent cell-sorting applications based on inertial focusing phenomena have attracted much interest during the last decade. The separation capability heavily depends on the precision of microparticle focusing. In this study, five-loop spiral microchannels with a height of 90 µm and a width of 500 µm are introduced. Unlike their original spiral counterparts, these channels have elliptic configurations of varying initial aspect ratios, namely major axis to minor axis ratios of 3:2, 11:9, 9:11, and 2:3. Accordingly, the curvature of these configurations increases in a curvilinear manner through the channel. The effects of the alternating curvature and channel Reynolds number on the focusing of fluorescent microparticles with sizes of 10 and 20 µm in the prepared suspensions were investigated. At volumetric flow rates between 0.5 and 3.5 mL/min (allowing separation), each channel was tested to collect samples at the designated outlets. Then, these samples were analyzed by counting the particles. These curved channels were capable of separating 20 and 10 µm particles with total yields up to approximately 95% and 90%, respectively. The results exhibited that the level of enrichment and the focusing behavior of the proposed configurations are promising compared to the existing microfluidic channel configurations.

Biomimetic technique for adhesion-based collection and separation of cells in a microfluidic channel

Lab on a Chip ◽  
2005 ◽  
Vol 5 (1) ◽  
pp. 64 ◽  
Author(s):  
Wesley C. Chang ◽  
Luke P. Lee ◽  
Dorian Liepmann
Keyword(s):  
Microfluidic Channel

scholarly journals A MEMS µ-Preconcentrator Employing a Carbon Molecular Sieve Membrane for Highly Volatile Organic Compound Sampling

Chemosensors ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 104
Author(s):  
Hung-Yang Kuo ◽  
Wei-Riu Cheng ◽  
Tzu-Heng Wu ◽  
Horn-Jiunn Sheen ◽  
Chih-Chia Wang ◽  
...  
Keyword(s):  
Organic Compound ◽  
Organic Compounds ◽  
Volatile Organic Compound ◽  
Molecular Sieve ◽  
Amplification Factor ◽  
Microfluidic Channel ◽  
Carbon Molecular Sieve ◽  
Volatile Organic ◽  
Chromatographic Peaks ◽  
Gaseous Toluene

This paper presents the synthesis and evaluation of a carbon molecular sieve membrane (CMSM) grown inside a MEMS-fabricated μ-preconcentrator for sampling highly volatile organic compounds. An array of µ-pillars measuring 100 µm in diameter and 250 µm in height were fabricated inside a microfluidic channel to increase the attaching surface for the CMSM. The surface area of the CMSM was measured as high as 899 m2/g. A GC peak amplification factor >2 × 104 was demonstrated with gaseous ethyl acetate. Up to 1.4 L of gaseous ethanol at the 100 ppb level could be concentrated without exceeding the capacity of this microchip device. Sharp desorption chromatographic peaks (<3.5 s) were obtained while using this device directly as a GC injector. Less volatile compounds such as gaseous toluene, m-xylene, and mesitylene appeared to be adsorbed strongly on CMSM, showing a memory effect. Sampling parameters such as sample volatilities, sampling capacities, and compound residual issues were empirically determined and discussed.

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