Platelet rich fibrin: a new paradigm in periodontal regeneration

2012 ◽  
Vol 14 (3) ◽  
pp. 453-463 ◽  
Author(s):  
R. Vinaya Kumar ◽  
N. Shubhashini
Keyword(s):  
Periodontal Regeneration ◽  
New Paradigm ◽  
Platelet Rich Fibrin

scholarly journals Platelet-Rich Fibrin Promotes Periodontal Regeneration and Enhances Alveolar Bone Augmentation

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Qi Li ◽  
Shuang Pan ◽  
Smit J. Dangaria ◽  
Gokul Gopinathan ◽  
Antonia Kolokythas ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Alveolar Bone ◽  
Periodontal Regeneration ◽  
Principal Component ◽  
Nodule Formation ◽  
Bone Augmentation ◽  
Pilot Studies ◽  
Platelet Rich Fibrin ◽  
Lineage Differentiation ◽  
Osteogenic Lineage

In the present study we have determined the suitability of platelet-rich fibrin (PRF) as a complex scaffold for periodontal tissue regeneration. Replacing PRF with its major component fibrin increased mineralization in alveolar bone progenitors when compared to periodontal progenitors, suggesting that fibrin played a substantial role in PRF-induced osteogenic lineage differentiation. Moreover, there was a 3.6-fold increase in the early osteoblast transcription factor RUNX2 and a 3.1-fold reduction of the mineralization inhibitor MGP as a result of PRF application in alveolar bone progenitors, a trend not observed in periodontal progenitors. Subcutaneous implantation studies revealed that PRF readily integrated with surrounding tissues and was partially replaced with collagen fibers 2 weeks after implantation. Finally, clinical pilot studies in human patients documented an approximately 5 mm elevation of alveolar bone height in tandem with oral mucosal wound healing. Together, these studies suggest that PRF enhances osteogenic lineage differentiation of alveolar bone progenitors more than of periodontal progenitors by augmenting osteoblast differentiation, RUNX2 expression, and mineralized nodule formation via its principal component fibrin. They also document that PRF functions as a complex regenerative scaffold promoting both tissue-specific alveolar bone augmentation and surrounding periodontal soft tissue regeneration via progenitor-specific mechanisms.

Tissue engineering: a new paradigm for periodontal regeneration based on molecular and cell biology

2000 ◽  
Vol 24 (1) ◽  
pp. 253-269 ◽  
Author(s):  
P. MARK BARTOLD ◽  
CHRISTOPHER A. G. MCCULLOCH ◽  
A. SAMPATH NARAYANAN ◽  
SANDU PITARU
Keyword(s):  
Tissue Engineering ◽  
Cell Biology ◽  
Periodontal Regeneration ◽  
New Paradigm

Stem cells: A new paradigm in periodontal regeneration

2013 ◽  
Vol 2 (2) ◽  
pp. 254
Author(s):  
Ameet Mani ◽  
Subhangi Mani ◽  
PP Marawar ◽  
Sagar K Shinde ◽  
Ishwardas D Patil
Keyword(s):  
Stem Cells ◽  
Periodontal Regeneration ◽  
New Paradigm

scholarly journals Efficacy of Platelet Rich Plasma and Platelet Rich Fibrin in Periodontal Regeneration: Systematic Review.

2018 ◽  
Vol 4 (3) ◽  
pp. 1196-1202
Author(s):  
Felipe Cid
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Platelet Rich Plasma ◽  
Periodontal Regeneration ◽  
The Body ◽  
Blood Collection ◽  
Platelet Rich Fibrin ◽  
Positive Effects ◽  
And Function

Regeneration is defined as the reproduction or reconstruction of a lost part or injury of the body in such a way that the architecture and function of the lost or injured tissue are completely restored. The goal of regenerative periodontal therapy is to restore the structure and function of the periodontium. The positive effects of Platelet-rich plasma (PRP) are attributed to the angiogenic, mitogenic and proliferative capacities of growth factors such as platelet-derived growth factor, transforming growth factor and vascular endothelial growth factor. Platelet-rich fibrin (PRF) is a second generation platelet concentrate that allows fibrin membranes enriched with platelets and growth factors to be obtained after starting an anticoagulant-free blood collection without any biomechanical artificial modification. The objective of this review is to know the efficacy of platelet-rich plasma and platelet-rich fibrin in the periodontal regeneration of intrabony defects. The clinical implications for this autologous material are promising. Further long term, larger, multicentred randomized controlled clinical trials are required to determine the effects of PRP and PRF on the regeneration of alveolar bone due to periodontal disease.

scholarly journals Effect of advanced platelet-rich fibrin applications on periodontal regeneration in infrabony pocket treatment

2019 ◽  
Vol 4 (3) ◽  
pp. 154
Author(s):  
Christopher Imantaka Suwondo ◽  
Dahlia Herawati ◽  
Sudibyo Sudibyo
Keyword(s):  
Tissue Regeneration ◽  
Alveolar Bone ◽  
Periodontal Regeneration ◽  
X Rays ◽  
Periodontal Tissue ◽  
Platelet Rich Fibrin ◽  
Attachment Loss ◽  
Probing Depth ◽  
Periodontal Tissue Regeneration ◽  
Bone Height

One of the regenerative periodontal treatments for infrabony pocket is open flap debridement (OFD) with the addition of growth factor derived from platelet concentrate. Advanced platelet-rich fibrin (A-PRF) is a further development of plateletrich fibrin (PRF) with a lower centrifugation speed (1,500 rpm, 14 minutes). The purpose of this study was to examine the differences in periodontal tissue regeneration after the application of A-PRF and PRF in the treatment of infrabony pockets evaluated from probing depth (PD), relative attachment loss (RAL), and alveolar bone height. The samples were taken from 20 infrabony pockets divided into 2 groups: 10 subjects were treated with OFD+A-PRF and OFD+PRF on the remaining subjects. Probing depth (PD) and relative attachment loss (RAL) measurement were performed on days 0, 30, and 90. Bone height measurements were performed using CBCT X-rays on days 0 and 90. The results showed that PD and RAL reduction in the group of OFD+A-PRF was significantly greater than that in the OFD+PRF group. Bone height reduction in both groups showed no difference. The conclusion obtained from this study is A-PRF application enhances periodontal tissue regeneration by generating greater probing depth and relative attachment loss reduction compared toPRF, as well as an increase in bone height similar to in the treatment of infrabony pockets.

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