Preoperative Antibiotic Prophylaxis Does Not Reduce the Risk of Postoperative Infectious Complications in Patients Undergoing Elective Hepatectomy

2015 ◽  
Vol 61 (6) ◽  
pp. 1707-1713 ◽  
Author(s):  
Yan-Ming Zhou ◽  
Zhen-Yi Chen ◽  
Xiu-Dong Li ◽  
Dong-Hui Xu ◽  
Xu Su ◽  
...  
Keyword(s):  
Antibiotic Prophylaxis ◽  
Infectious Complications ◽  
Preoperative Antibiotic Prophylaxis

A nationwide prospective multicenter study of external ventricular drainage: accuracy, safety, and related complications

2021 ◽  
pp. 1-9
Author(s):  
Ayoub Dakson ◽  
Michelle Kameda-Smith ◽  
Michael D. Staudt ◽  
Pascal Lavergne ◽  
Serge Makarenko ◽  
...  
Keyword(s):  
Antibiotic Prophylaxis ◽  
Clinical Manifestations ◽  
External Ventricular Drainage ◽  
Infectious Complications ◽  
Ventricular Drainage ◽  
Midline Shift ◽  
Operator Experience ◽  
Vein Thrombosis ◽  
Preoperative Antibiotic Prophylaxis ◽  
Catheter Replacement

OBJECTIVE External ventricular drainage (EVD) catheters are associated with complications such as EVD catheter infection (ECI), intracranial hemorrhage (ICH), and suboptimal placement. The aim of this study was to investigate the rates of EVD catheter complications and their associated risk factor profiles in order to optimize the safety and accuracy of catheter insertion. METHODS A total of 348 patients with urgently placed EVD catheters were included as a part of a prospective multicenter observational cohort. Strict definitions were applied for each complication category. RESULTS The rates of misplacement, ECI/ventriculitis, and ICH were 38.6%, 12.2%, and 9.2%, respectively. Catheter misplacement was associated with midline shift (p = 0.002), operator experience (p = 0.031), and intracranial length (p < 0.001). Although mostly asymptomatic, ICH occurred more often in patients receiving prophylactic low-molecular-weight heparin (LMWH) (p = 0.002) and those who required catheter replacement (p = 0.026). Infectious complications (ECI/ventriculitis and suspected ECI) occurred more commonly in patients whose catheters were inserted at the bedside (p = 0.004) and those with smaller incisions (≤ 1 cm) (p < 0.001). ECI/ventriculitis was not associated with preinsertion antibiotic prophylaxis (p = 0.421), catheter replacement (p = 0.118), and catheter tunneling length (p = 0.782). CONCLUSIONS EVD-associated complications are common. These results suggest that the operating room setting can help reduce the risk of infection, but not the use of preoperative antibiotic prophylaxis. Although EVD-related ICH was associated with LMWH prophylaxis for deep vein thrombosis, there were no significant clinical manifestations in the majority of patients. Catheter misplacement was associated with operator level of training and midline shift. Information from this multicenter prospective cohort can be utilized to increase the safety profile of this common neurosurgical procedure.

Antibiotic prophylaxis for prevention of infectious complications after shockwave lithotripsy: A systematic review and meta-analysis

2021 ◽  
Vol 79 ◽  
pp. S242-S243
Author(s):  
B. Tadayon Najafabadi ◽  
M. Kandi ◽  
M. Ding ◽  
T. Bladeh ◽  
K. Bausch ◽  
...  
Keyword(s):  
Systematic Review ◽  
Antibiotic Prophylaxis ◽  
Meta Analysis ◽  
Infectious Complications ◽  
Shockwave Lithotripsy

scholarly journals Antibiotic Use in Hand Surgery: Surgeon Decision Making and Adherence to Available Evidence

Hand ◽  
2018 ◽  
Vol 15 (4) ◽  
pp. 534-541 ◽  
Author(s):  
John C. Dunn ◽  
Kenneth R. Means ◽  
Sameer Desale ◽  
Aviram M. Giladi
Keyword(s):  
Antibiotic Prophylaxis ◽  
Hand Surgery ◽  
Antibiotic Use ◽  
Demographic Variables ◽  
Fisher Exact Test ◽  
Evidence Based ◽  
Supporting Evidence ◽  
Exact Test ◽  
Preoperative Antibiotic Prophylaxis ◽  
Group 1

Background: There are no clearly defined guidelines from hand surgical societies regarding preoperative antibiotic prophylaxis. Many hand surgeons continue to routinely use preoperative prophylaxis with limited supporting evidence. This study aimed to determine for which scenarios surgeons give antibiotics, the reasons for administration, and whether these decisions are evidence-based. Methods: An anonymous 25-question survey was e-mailed to the 921-member American Society for Surgery of the Hand listserv. We collected demographic information; participants were asked whether they would administer antibiotics in a number of surgical scenarios and for what reasons. Respondents were broken into 3 groups based on when they said they would administer antibiotics: Group 1 (40 respondents) would give antibiotics in the case of short cases, healthy patients, without hardware; group 2 (9 respondents) would not give antibiotics in any scenario; and group 3 (129 respondents) would give antibiotics situationally. The Fisher exact test compared demographic variables, frequency of use, and indications of antibiotic prophylaxis. Results: Of the 921 recipients, 178 (19%) responded. Demographic variables did not correlate with the antibiotic use group. Operative case time >60 minutes, medical comorbidity, and pinning each increased antibiotic use. Group 1 respondents were more likely to admit that their practice was not evidence-based (74.4%) and that they gave antibiotics for medical-legal concern (75%). Twenty-two percent of respondents reported seeing a complication from routine prophylaxis, including Clostridium difficile infection. Conclusions: Antibiotics are still given unnecessarily before hand surgery, most often for medical-legal concern. Clear guidelines for preoperative antibiotic use may help reduce excessive and potentially inappropriate treatment and provide medical-legal support.

scholarly journals Antibiotic prophylaxis of acute postoperative endophthalmitis

2021 ◽  
Vol 21 (4) ◽  
pp. 220-226
Author(s):  
V.P. Nikolaenko ◽  
◽  
D.F. Belov ◽  
◽  
Keyword(s):  
Antibiotic Prophylaxis ◽  
Povidone Iodine ◽  
Legal Aspects ◽  
Infectious Complications ◽  
Published Data ◽  
Antibacterial Prophylaxis ◽  
Postoperative Endophthalmitis ◽  
Bacterial Strains ◽  
Routes Of Administration ◽  
Causative Agents

This paper reviews current aspects of antibacterial prophylaxis of acute endophthalmitis, a dangerous complication of cataract surgery. The lack of a common standard for preventing phaco infectious complications, a growing number of resistant bacterial strains, and legal aspects of the lack of some antibiotic formulations and routes of their administration with established efficacy in Russia account for the importance of this issue. The authors provide a list of primary causative agents of endophthalmitis and specify their antimicrobial susceptibility, highlight the importance of using antiseptics to prevent endophthalmitis, and describe in detail routes of administration of antibiotics, including conventional ones (subconjunctival injections, topical use) and whose actively promoted (intracameral, transzonular). In conclusion, the authors suggested a rational antimicrobial preventive algorithm for endophthalmitis after phaco based on the analysis of recent Russian and foreign published data and adapted to the Russian health care system. Keywords: phacoemulsification, endophthalmitis, antiseptic, antibiotic, prophylaxis, antibacterial resistance, fluoroquinolones, aminoglycosides, povidone-iodine, intracameral administration. For citation: Nikolaenko V.P., Belov D.F. Antibiotic prophylaxis of acute postoperative endophthalmitis. Russian Journal of Clinical Ophthalmology. 2021;21(4):220–226 (in Russ.). DOI: 10.32364/2311-7729-2021-21-4-220-226.

scholarly journals Systemic antibiotic prophylaxis does not affect infectious complications in pediatric burn injury: A meta-analysis

PLoS ONE ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. e0223063 ◽  
Author(s):  
Alexandra Csenkey ◽  
Gergo Jozsa ◽  
Noemi Gede ◽  
Eszter Pakai ◽  
Benedek Tinusz ◽  
...  
Keyword(s):  
Antibiotic Prophylaxis ◽  
Burn Injury ◽  
Meta Analysis ◽  
Infectious Complications ◽  
Systemic Antibiotic ◽  
Systemic Antibiotic Prophylaxis
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