scholarly journals Lactobacillus rhamnosus Affects Rat Peritoneal Cavity Cell Response to Stimulation with Gut Microbiota: Focus on the Host Innate Immunity

Inflammation ◽  
2021 ◽  
Author(s):  
Stanislava Stanojević ◽  
Veljko Blagojević ◽  
Ivana Ćuruvija ◽  
Vesna Vujić
Keyword(s):  
Innate Immunity ◽  
Gut Microbiota ◽  
Peritoneal Cavity ◽  
Cell Response ◽  
Lactobacillus Rhamnosus ◽  
Host Innate Immunity

scholarly journals Lactobacillus rhamnosus HDB1258 modulates gut microbiota-mediated immune response in mice with or without lipopolysaccharide-induced systemic inflammation

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sang-Kap Han ◽  
Yeon-Jeong Shin ◽  
Dong-Yeon Lee ◽  
Kyung Min Kim ◽  
Seo-Jin Yang ◽  
...  
Keyword(s):  
Immune Response ◽  
Gut Microbiota ◽  
Oral Administration ◽  
Systemic Inflammation ◽  
Nk Cell ◽  
Lactobacillus Rhamnosus ◽  
Expression Ratio ◽  
Macrophage Phagocytosis ◽  
Tnf Α ◽  
Gut Microbiota Composition

Abstract Background Gut microbiota closely communicate in the immune system to maintain a balanced immune homeostasis in the gastrointestinal tract of the host. Oral administration of probiotics modulates gut microbiota composition. In the present study, we isolated Lactobacillus rhamnosus HDB1258, which induced tumor necrosis factor (TNF)-α and interleukin (IL)-10 expression in macrophages, from the feces of breastfeeding infants and examined how HDB1258 could regulate the homeostatic immune response in mice with or without lipopolysaccharide (LPS)-induced systemic inflammation. Results Oral administration of HDB1258 significantly increased splenic NK cell cytotoxicity, peritoneal macrophage phagocytosis, splenic and colonic TNF-α expression, TNF-α to IL-10 expression ratio, and fecal IgA level in control mice, while Th1 and Treg cell differentiation was not affected in the spleen. However, HDB1258 treatment significantly suppressed peritoneal macrophage phagocytosis and blood prostaglandin E2 level in mice with LPS-induced systemic inflammation. Its treatment increased LPS-suppressed ratios of Treg to Th1 cell population, Foxp3 to T-bet expression, and IL-10 to TNF-α expression. Oral administration of HDB1258 significantly decreased LPS-induced colon shortening, myeloperoxidase activity and NF-κB+/CD11c+ cell population in the colon, while the ratio of IL-10 to TNF-α expression increased. Moreover, HDB1258 treatment shifted gut microbiota composition in mice with and without LPS-induced systemic inflammation: it increased the Cyanobacteria and PAC000664_g (belonging to Bacteroidetes) populations and reduced Deferribacteres and EU622763_s group (belonging to Bacteroidetes) populations. In particular, PAC001066_g and PAC001072_s populations were negatively correlated with the ratio of IL-10 to TNF-α expression in the colon, while the PAC001070_s group population was positively correlated. Conclusions Oral administered HDB1258 may enhance the immune response by activating innate immunity including to macrophage phagocytosis and NK cell cytotoxicity in the healthy host and suppress systemic inflammation in the host with inflammation by the modulation of gut microbiota and IL-10 to TNF-α expression ratio in immune cells.

Fermented carrot juice attenuates type 2 diabetes by mediating gut microbiota in rats

2019 ◽  
Vol 10 (5) ◽  
pp. 2935-2946 ◽  
Author(s):  
Rongkang Hu ◽  
Feng Zeng ◽  
Linxiu Wu ◽  
Xuzhi Wan ◽  
Yongfang Chen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acid ◽  
Gut Microbiota ◽  
Short Chain Fatty Acid ◽  
Lactobacillus Rhamnosus ◽  
Chain Fatty Acid ◽  
Carrot Juice ◽  
Protein Expressions ◽  
Free Phenolics

Carrot juice fermented with Lactobacillus rhamnosus GG, enriched with free phenolics, organic acids and short-chain fatty acid, has the potential to ameliorate type 2 diabetes, in part through modulating specific gut microbiota and regulating the mRNA and protein expressions levels involved in glucose metabolism.

P122 Dengue virus targets the adaptor protein MITA to subvert host innate immunity

Cytokine ◽  
2012 ◽  
Vol 59 (3) ◽  
pp. 558 ◽  
Author(s):  
C.-Y. Yu ◽  
T.-H. Chang ◽  
J.-J. Liang ◽  
R.-L. Chiang ◽  
Y.-L. Lee ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Dengue Virus ◽  
Adaptor Protein ◽  
Host Innate Immunity

scholarly journals Advances in Foot-and-Mouth Disease Virus Proteins Regulating Host Innate Immunity

2020 ◽  
Vol 11 ◽  
Author(s):  
Jiangling Peng ◽  
Jiamin Yi ◽  
Wenping Yang ◽  
Jingjing Ren ◽  
Yuan Wen ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth ◽  
Host Innate Immunity ◽  
Virus Proteins

scholarly journals A New Mouse Model Reveals a Critical Role for Host Innate Immunity in Resistance to Rift Valley Fever

2010 ◽  
Vol 185 (10) ◽  
pp. 6146-6156 ◽  
Author(s):  
Tânia Zaverucha do Valle ◽  
Agnès Billecocq ◽  
Laurent Guillemot ◽  
Rudi Alberts ◽  
Céline Gommet ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Mouse Model ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Critical Role ◽  
Valley Fever ◽  
Host Innate Immunity
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