Analgesic and anti-inflammatory effect of aqueous extract of the stem bark of Allanblackia gabonensis (Guttiferae)

2011 ◽  
Vol 21 (1) ◽  
pp. 21-30 ◽  
Author(s):  
Edwige V. Ymele ◽  
A. Bertrand Dongmo ◽  
Théophile Dimo
Keyword(s):  
Aqueous Extract ◽  
Stem Bark ◽  
Anti Inflammatory ◽  
Allanblackia Gabonensis ◽  
Inflammatory Effect

Anti-inflammatory and anti-arthritic properties of aqueous extract of Nauclea diderrichii (Rubiaceae) stem bark in rats

2020 ◽  
Vol 20 (2) ◽  
pp. 199-212
Author(s):  
Marius Mbiantcha ◽  
Marcelle Bejoutance Djami ◽  
Gilbert Ateufack ◽  
Donatien Albert Atsamo ◽  
Gonzal Eric Tsafack ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Stem Bark ◽  
Nauclea Diderrichii ◽  
Anti Inflammatory

scholarly journals Pharmacognostic Screening and Anti-inflammatory Investigation of the Methanol extract of stem bark of Blighia unijugata Baker (Sapindaceae)

2020 ◽  
Vol 10 (4) ◽  
pp. 146-152
Author(s):  
Felix N. Osuala ◽  
Uchenna E. Odoh ◽  
VictoriaC. Onuigbo ◽  
Sylvester C. Ohadoma
Keyword(s):  
Methanol Extract ◽  
Lethal Dose ◽  
Numerical Data ◽  
Stem Bark ◽  
Water Soluble ◽  
Herbal Remedies ◽  
Albino Rats ◽  
Standard Drug ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Introduction: Blighia unijugata is a potent medicinal plant extensively employed in traditional herbal remedies for the treatment of various diseases such as fever, fertility, inflammation, hypertension, migraine and treatment of infections due to microorganisms. Aim: This work, investigates the pharmacognostic screening and anti-inflammatory activities of the methanol extract of B. unijugata stem bark. Method: Collection, drying, pulverization, and methanol extraction of the stem bark were done accordingly. The screening of phytochemical constituents and Pharmacognostic numerical data were carried out. The chromatographic analysis was carried out using TLC. The acute toxicity was determined using Lorke’s method. Methanol extract was investigated for anti-inflammatory effect in albino rats using egg-induced hind paw oedema at doses of 200, 400 and 600mg/kg body weight respectively. Result: The macroscopical investigation showed the stem bark outer layer is greyish and, the inner layer is pale reddish brown, disagreeable odour, bitter, Microscopical screening revealed the presence of starch grains, trichomes and sclerenchyma cells. Chemomicroscopic result revealed the presence of lignin, starch, calcium oxalate, cellulose, stone cells. Qualitative phytochemical screening of the powdered bark showed the presence of saponins, steroids, tannins, and resins. Numerical data: moisture content/ weight loss on drying gave value of 7.7%, percentage yield of 6.7%, alcoholic soluble extractive 5.6%, water soluble extractive 6.3%, total ash of 7.1%,  acid insoluble ash 0.57% and water soluble ash 4.56%. The chromatographic screening results were close compared with the standard drug. Toxicity test established the lethal dose of greater than 5000mg/kg. There was a significant inhibition of the edema p>0.05, the presence of various bioactive constituents may have contributed to the anti-inflammatory properties of the plant extract. Conclusion: The result of this study confirms that the barks of B. unijugata have anti-inflammatory effect and justifies the use as traditional treatment of inflammation and pain. Keywords: Blighia unijugata, Inflammation, Inflammatory agents, Anti inflammatory

scholarly journals Investigation of Anti-inflammatory Effect of Aqueous Extract of Cuminum cyminum L. by Formalin Inflammatory Model in Male Rats

2020 ◽  
Vol 4 (72) ◽  
pp. 236-246
Author(s):  
Sahar Golabi ◽  
Asma Mohammadi ◽  
Narges Chamkouri ◽  
◽  
◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Male Rats ◽  
Cuminum Cyminum ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Acute toxicity, anti-inflammatory, analgesic and antipyretic effects of aqueous and hydroethanolic extracts of Brenania brieyi (Rubiaceae)

2021 ◽  
Vol 3 (1) ◽  
pp. 019-032
Author(s):  
Nkundineza JC ◽  
Nsonde Ntandou GF ◽  
Boumba LS ◽  
Kibamgou S ◽  
Motondo E ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Acute Toxicity ◽  
Aqueous Extract ◽  
Ethanolic Extract ◽  
Tail Flick ◽  
Pharmacological Effects ◽  
Tail Flick Test ◽  
Ethanolic Extracts ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Brenania brieyi (Rubiaceae) is widely used in traditional Congolese medicine in the treatment of many pathologies that are manifested by inflammation, pain and fever. The objective of this study was to study the acute toxicity as well as to evaluate the antipyretic, analgesic and anti-inflammatory effects of the aqueous and hydro-ethanolic extracts of Brenania brieyibark on models of pyrexia, algesia and inflammation induced in rodents. The aqueous extract of Brenania brieyidoes not cause any mortality up to the dose of 4000 mg/kg, but promotes a slight increase in body weight. From 2000 mg/kg, the signs of toxicity observed were the significant decrease in mobility as well as the loss of alertness. At doses of 100 and 200 mg/kg, aqueous and hydro-ethanolic Brenania brieyiextracts showed a very significant anti-inflammatory effect (***p< 0.001) on edemas induced by carrageenin (1%), formaldehyde (2.5%) and histamine (1 mg/mL), greater than that of diclofenac at 10 mg/kg. At 200 mg/kg, both extracts showed a very significant analgesic effect (***p< 0.001), greater than that of paracetamol 100 mg/kg against pain induced by acetic acid 0.6% and formaldehyde 2.5%. Brenania brieyiwas slightly effective in the tail flick test. Brewer's yeast-induced hyperthermia was reduced by both extracts. However, the hydro-ethanolic extract proves to be more effective than the aqueous extract in all the tests carried out. These pharmacological effects would be related to the presence of alkaloids, tannins, flavonoids, anthraquinones, oses and saponosides.

scholarly journals Effects of Methanol Extract of Piper chaba Stem Bark on Acute Inflammation in rats

2012 ◽  
Vol 7 (1) ◽  
pp. 26-28
Author(s):  
F Begum ◽  
ZA Begum ◽  
MR Uddin ◽  
AHMZ Haider ◽  
RC Barman
Keyword(s):  
Body Weight ◽  
Acute Inflammation ◽  
Methanol Extract ◽  
Stem Bark ◽  
Oedema Formation ◽  
Medicinal Value ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The plant Piper chaba Hunter (Piperaceae), a climbing glabrous shrub grows in plenty in southern Bangladesh. Popularly known as 'Choi' it is used as spices and believed to have medicinal value in a wide variety of disease conditions including arthritis, asthma, bronchitis and piles. In the present study, effect of methanol extract of Piper chaba stem bark on acute inflammation has been reported. The anti-inflammatory effect was studied in rats by injecting 0.1ml of 1% carrageenan suspension into the planter surface, where oedema of the rat's hind paw was used as an index of acute inflammation. Methanol extract of Piper chaba stem bark given orally 1 hour before injection at doses of 125 and 250 mg/kg body weight, produced significant (p< 0.05) anti inflammatory effect compared to control and the percentage of inhibition of oedema formation was 33% and 35% respectively, which however was less compared to aspirin (46%) and hydrocortisone (56%). The result suggest that in case of acute inflammation, Piper chaba stem bark possess mild to moderate anti inflammatory effect compared to that of aspirin and hydrocortisone.DOI: http://dx.doi.org/10.3329/fmcj.v7i1.10294Faridpur Med. Coll. J. 2012;7(1): 26-28

scholarly journals Studies on anti-inflammatory effect of aqueous extract of leaves ofHoloptelea integrifolia, Planch. in rats

2009 ◽  
Vol 41 (2) ◽  
pp. 87 ◽  
Author(s):  
Shrinivas Sharma ◽  
KS Lakshmi ◽  
Arjun Patidar ◽  
Abhinav Chaudhary ◽  
Sanjay Dhaker
Keyword(s):  
Aqueous Extract ◽  
Anti Inflammatory ◽  
Inflammatory Effect
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