scholarly journals In vitro fertilization with granulosa cell tumor: a report of two cases

2018 ◽  
Vol 35 (10) ◽  
pp. 1919-1921 ◽  
Author(s):  
Tiffany Phyoe-Battaglia ◽  
Chantal Bartels ◽  
John Nulsen ◽  
Daniel R. Grow
Keyword(s):  
In Vitro Fertilization ◽  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Vitro Fertilization

scholarly journals Granulosa Cell Steroidogenesis Before In Vitro Fertilization

1984 ◽  
Vol 31 (4) ◽  
pp. 679-686 ◽  
Author(s):  
S. G. Hillier ◽  
E. J. Wickings ◽  
M. Afnan ◽  
R. A. Margara ◽  
R.M.L. Winston
Keyword(s):  
In Vitro Fertilization ◽  
Granulosa Cell ◽  
Vitro Fertilization

Endocrinology: The effect of growth hormone on granulosa cell function during in-vitro fertilization

1993 ◽  
Vol 8 (10) ◽  
pp. 1588-1592 ◽  
Author(s):  
J.S. Younis ◽  
Y. Ezra ◽  
A. Brzezinnski ◽  
T. Fibich ◽  
J.G. Schenker ◽  
...  
Keyword(s):  
Growth Hormone ◽  
In Vitro Fertilization ◽  
Granulosa Cell ◽  
Cell Function ◽  
Vitro Fertilization

scholarly journals Procaspase-Activating Compound-1 Synergizes with TRAIL to Induce Apoptosis in Established Granulosa Cell Tumor Cell Line (KGN) and Explanted Patient Granulosa Cell Tumor Cells In Vitro

2021 ◽  
Vol 22 (9) ◽  
pp. 4699
Author(s):  
Powel Crosley ◽  
Anniina Farkkila ◽  
Adrianne L. Jenner ◽  
Chloé Burlot ◽  
Olivia Cardinal ◽  
...  
Keyword(s):  
Cell Line ◽  
Granulosa Cell ◽  
Tumor Cell Line ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Viability Assay ◽  
Wide Range ◽  
Rapid Kinetics ◽  
Apoptosis Inducing Agents

Granulosa cell tumors (GCT) constitute only ~5% of ovarian neoplasms yet have significant consequences, as up to 80% of women with recurrent GCT will die of the disease. This study investigated the effectiveness of procaspase-activating compound 1 (PAC-1), an activator of procaspase-3, in treating adult GCT (AGCT) in combination with selected apoptosis-inducing agents. Sensitivity of the AGCT cell line KGN to these drugs, alone or in combination with PAC-1, was tested using a viability assay. Our results show a wide range in cytotoxic activity among the agents tested. Synergy with PAC-1 was most pronounced, both empirically and by mathematical modelling, when combined with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). This combination showed rapid kinetics of apoptosis induction as determined by caspase-3 activity, and strongly synergistic killing of both KGN as well as patient samples of primary and recurrent AGCT. We have demonstrated that the novel combination of two pro-apoptotic agents, TRAIL and PAC-1, significantly amplified the induction of apoptosis in AGCT cells, warranting further investigation of this combination as a potential therapy for AGCT.

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