scholarly journals A biophysical model of the cortex-basal ganglia-thalamus network in the 6-OHDA lesioned rat model of Parkinson’s disease

2016 ◽  
Vol 40 (2) ◽  
pp. 207-229 ◽  
Author(s):  
Karthik Kumaravelu ◽  
David T. Brocker ◽  
Warren M. Grill
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Rat Model ◽  
Biophysical Model

scholarly journals Neuronal Entropy-Rate Feature of Entopeduncular Nucleus in Rat Model of Parkinson’s Disease

2016 ◽  
Vol 26 (02) ◽  
pp. 1550038 ◽  
Author(s):  
Olivier Darbin ◽  
Xingxing Jin ◽  
Christof Von Wrangel ◽  
Kerstin Schwabe ◽  
Atsushi Nambu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Normal Condition ◽  
Rat Model ◽  
Neuronal Firing ◽  
Entopeduncular Nucleus ◽  
Motor Processing ◽  
Firing Rates ◽  
Sensory Motor

The function of the nigro-striatal pathway on neuronal entropy in the basal ganglia (BG) output nucleus, i.e. the entopeduncular nucleus (EPN) was investigated in the unilaterally 6-hyroxydopamine (6-OHDA)-lesioned rat model of Parkinson’s disease (PD). In both control subjects and subjects with 6-OHDA lesion of dopamine (DA) the nigro-striatal pathway, a histological hallmark for parkinsonism, neuronal entropy in EPN was maximal in neurons with firing rates ranging between 15 and 25[Formula: see text]Hz. In 6-OHDA lesioned rats, neuronal entropy in the EPN was specifically higher in neurons with firing rates above 25[Formula: see text]Hz. Our data establishes that the nigro-striatal pathway controls neuronal entropy in motor circuitry and that the parkinsonian condition is associated with abnormal relationship between firing rate and neuronal entropy in BG output nuclei. The neuronal firing rates and entropy relationship provide putative relevant electrophysiological information to investigate the sensory-motor processing in normal condition and conditions such as movement disorders.

Cannabinoid effects in basal ganglia in a rat model of Parkinson's disease

1998 ◽  
Vol 248 (3) ◽  
pp. 171-174 ◽  
Author(s):  
M.Clara Sañudo-Peña ◽  
Saundra L Patrick ◽  
Somphone Khen ◽  
Robert L Patrick ◽  
Kang Tsou ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Rat Model
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