scholarly journals Perceived racism, affectivity, and C-reactive protein in healthy African Americans: Do religiosity and racial identity provide complementary protection?

2020 ◽  
Vol 43 (6) ◽  
pp. 932-942
Author(s):  
Caroline E. Drolet ◽  
Todd Lucas
Keyword(s):  
Racial Identity ◽  
African Americans ◽  
Perceived Racism ◽  
C Reactive Protein ◽  
Reactive Protein

Abstract P002: Evidence For Smoking Dependent Genetic Effects on C-reactive Protein Levels in a Multi-ethnic Cohort Setting: The Care Consortium.

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Jaclyn Ellis ◽  
Jeremy Walston ◽  
Josee Dupuis ◽  
Emma Larkin ◽  
Maja Barbalic ◽  
...  
Keyword(s):  
African Americans ◽  
Candidate Gene ◽  
Meta Analysis ◽  
Cardiovascular Health Study ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
European Americans ◽  
Heart Study ◽  
Study Results ◽  
Never Smokers

INTRODUCTION: C-reactive protein (CRP) is a heritable biomarker of systemic inflammation and a predictor of cardiovascular disease (CVD). Cigarette smoking is a major risk factor in the development of CVD and has been shown to affect circulating levels of CRP. Therefore, we sought to determine how this important environmental exposure may influence genetic associations with CRP in a multi-ethnic setting. METHODS: Using the ITMAT Broad-CARe (IBC) SNP array, a custom 50,000 SNP gene-centric array having dense coverage of over 2,000 candidate genes for CVD pathways, we performed a meta-analysis of up to 26,065 participants of European descent and 7,584 participants of African descent for association with log-CRP level within smoking status stratum. The 2 smoking strata were: never smokers and ever smokers (comprising of current and former smokers). We conducted IBC-wide association scans for CRP within cohort-, race- and smoking-stratum and meta-analyzed by race. Samples were from the Candidate gene Association Resource (CARe) cohorts (Atherosclerosis Risk in Communities Study, Framingham Heart Study, Cardiovascular Health Study, Cleveland Family Study , Coronary Artery Risk Development in Young Adults Study, Jackson Heart Study, and Multi-Ethnic Study of Atherosclerosis Study). Results were considered to be panel wide statistically significant if p<2.2×10−6. RESULTS: The overall sample size for ever smokers (never smokers) was 11,698 (10,344) in European Americans and 3,448 (4,330) in African Americans. The per-allele beta coefficients for genes previously established to be associated with CRP and present on the IBC chip ( CRP, APOE, GCKR, IL6R, LEPR, HNF1A, NLRP3 ) were very similar in magnitude between smoking strata in European Americans. However, in the African Americans, the estimated per-allele CRP and IL6R betas were 2-times larger for the ever smokers as compared to the never smokers. In the European American analysis, one gene not previously reported for association with CRP reached IBC-wide significance for a CRP-lowering effect in the never smokers ( GSTT1 , p=4.8E-07 for SNP rs405597 ), but not in the ever smokers (p=0.078). CONCLUSION: This large scale candidate gene based meta-analysis identified one novel locus for CRP ( GSTT1 ) associated with serum CRP levels in those reporting having never regularly smoked. Polymorphisms in GSTT1 , which plays a role in detoxification, have previously been reported to interact with smoking for other phenotypes including birth weight and colorectal cancer. We also observed evidence that smoking modifies the effects for previously established loci CRP and IL6R in African Americans. These results may identify important context genetic specific effects that influence chronic inflammation.

OBESITY, DIABETES, AND INSULIN RESISTANCE: RELATION TO ELEVATED C-REACTIVE PROTEIN LEVELS IN AFRICAN AMERICANS.

2007 ◽  
Vol 55 (1) ◽  
pp. S257
Author(s):  
J. K. Taylor ◽  
H. A. Taylor ◽  
E. J. Benjamin ◽  
C. N. Rotimi ◽  
D. F. Sarpong ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
African Americans ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

scholarly journals H. pylori-induced higher C-reactive protein in obese African Americans

2009 ◽  
Vol 3 (1) ◽  
pp. 39 ◽  
Author(s):  
Nuzhat R. Siddiqui ◽  
W. Timothy Garvey ◽  
Mohammad A. Khaled
Keyword(s):  
African Americans ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
H Pylori

scholarly journals High-Sensitivity C-Reactive Protein Is Associated With Incident Type 2 Diabetes Among African Americans: The Jackson Heart Study

Diabetes Care ◽  
2015 ◽  
Vol 38 (9) ◽  
pp. 1694-1700 ◽  
Author(s):  
Valery S. Effoe ◽  
Adolfo Correa ◽  
Haiying Chen ◽  
Mary E. Lacy ◽  
Alain G. Bertoni
Keyword(s):  
Type 2 Diabetes ◽  
African Americans ◽  
High Sensitivity ◽  
Jackson Heart Study ◽  
C Reactive Protein ◽  
Incident Type ◽  
Reactive Protein ◽  
Heart Study ◽  
Incident Type 2 Diabetes

scholarly journals The association of C-reactive protein and physical activity among a church-based population of African Americans

2015 ◽  
Vol 77 ◽  
pp. 137-140 ◽  
Author(s):  
Swann Arp Adams ◽  
Michael D. Wirth ◽  
Samira Khan ◽  
E. Angela Murphy ◽  
Sue P. Heiney ◽  
...  
Keyword(s):  
Physical Activity ◽  
African Americans ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals C-Reactive Protein Levels in African Americans

2013 ◽  
Vol 45 (4) ◽  
pp. 430-440 ◽  
Author(s):  
James R. Hébert ◽  
Michael Wirth ◽  
Lisa Davis ◽  
Briana Davis ◽  
Brook E. Harmon ◽  
...  
Keyword(s):  
African Americans ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

scholarly journals Gene-Specific DNA Methylation Association with Serum Levels of C-Reactive Protein in African Americans

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e73480 ◽  
Author(s):  
Yan V. Sun ◽  
Alicia Lazarus ◽  
Jennifer A. Smith ◽  
Yu-Hsuan Chuang ◽  
Wei Zhao ◽  
...  
Keyword(s):  
Dna Methylation ◽  
African Americans ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Reactive Protein

Abstract 020: C-reactive Protein As A Moderator And Insulin Resistance As A Mediator For The Association Between Endothelin-1 And Type 2 Diabetes Progression Among African Americans In The Jackson Heart Study

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Xiang Gao ◽  
Steven R Horbal ◽  
Hao Fan ◽  
Le Su ◽  
Solomon K Musani ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
African Americans ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Heart Study ◽  
Diabetes Progression ◽  
Adjusted Model ◽  
Multivariable Adjusted Model

Objective: Little is known about the moderation and mediation factors among the association between endothelin-1 (ET-1) level and type 2 diabetes progression in African Americans. We explored the role of high sensitivity C-reactive protein (hsCRP) as a moderator and homeostatic model assessment of insulin resistance (HOMA-IR) as a mediator for the association between ET-1 level and type 2 diabetes progression among African Americans enrolled in the Jackson Heart Study (JHS). Methods: We included 1,692 participants free of prediabetes and diabetes at baseline, who attended Exam 1 of the JHS in 2000-2004 and Exam 3 in 2009-2013, and with measured ET-1 level at Exam 1. Incident prediabetes and diabetes were ascertained at Exam 3. We used a sequential regression model procedure. Zou’s modified Poisson multivariable models were used to calculate risk ratios (RR) and 95% confidence intervals (CI) for prediabetes and diabetes. Effect modification was assessed in the multivariable adjusted model. Valeri and VanderWeele’s mediation analysis approach was utilized to evaluate mediation. Results: A higher log-transformed ET-1 level was detected when comparing non-diabetes versus prediabetes and diabetes participants (p-value for trend = 0.03). Compared to quartile 1 (<0.9 pg/mL) of ET-1, quartile 2 (0.9-1.2 pg/mL) of ET-1 was significantly associated with higher risk of prediabetes (RR=1.19 [95% CI 1.02, 1.38]) and diabetes (RR=1.19 [95% CI 1.02, 1.40]). This association only remained significant for diabetes in the multivariable adjusted model (RR=1.20 [95% CI 1.02, 1.40]) and was not attenuated after adjusted for hsCRP (RR=1.20 [95% CI 1.03, 1.40]), HOMA-IR (RR=1.20 [95% CI 1.02, 1.40]), and both hsCRP and HOMA-IR (RR=1.20 [95% CI 1.03, 1.40]) in quartile 2 of ET-1.The risk of elevated ET-1 level on diabetes was higher in participants with increased hsCRP level in the multivariable adjusted model (RR=1.06 [95% CI 1.02, 1.09]), and further adjusted for HOMA-IR (RR=1.06 [95% CI 1.02, 1.09]. The indirect effect of ET-1 on prediabetes through HOMA-IR is 0.96 (P<0.01), but not found for hsCRP (p=0.26). The total effect of ET-1 on prediabetes mediated by HOMA-IR is 47%. No such mediation effect of HOMA-IR was found among diabetes participants. Conclusions: African Americans with higher ET-1 levels have a higher risk of prediabetes and diabetes. Additionally, the risk of diabetes is elevated among those African Americans with increased hsCRP levels. The mediation analysis result supports that ET-1 is involved in the stage of glucose metabolism imbalances leading to diabetes progression.

scholarly journals Role of plasma adiponectin /C-reactive protein ratio in obesity and type 2 diabetes among African Americans

2017 ◽  
Vol 17 (1) ◽  
pp. 99 ◽  
Author(s):  
Preetha Anna Abraham ◽  
Selasi Attipoe ◽  
Josh B. Kazman ◽  
Stacey Anne Zeno ◽  
Merrily Poth ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
African Americans ◽  
C Reactive Protein ◽  
Protein Ratio ◽  
Plasma Adiponectin ◽  
Reactive Protein
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