There is growing recognition that it is important to understand how spirituality is related to mental health and distress, and how it can be integrated into psychotherapy. Spiritually integrated psychotherapy (SIP) involves the adaptation of secular psychotherapies in order to be more culturally sensitive and client-centred to spiritually and religiously inclined clients. Literature shows that SIPs are at least as effective as conventional psychotherapy for treating different mental disorders, and cognitive behavioural therapy (CBT) is the most widely investigated clinical modality that has been adapted to include spiritual content. The objective of this chapter is to describe the adaptation of traditional CBT techniques by integrating spirituality to enhance cognitive restructuring, behavioural activation, coping, psychoeducation, and to facilitate greater motivation for treatment. Several practical examples are given, including the use of meditation and prayer in the treatment process.