Multifunctional porous silica nanoparticles for dual responsive drug release

2019 ◽  
Vol 93 (2) ◽  
pp. 324-331
Author(s):  
Xindang Bo ◽  
Qianqian Zhang ◽  
Xinli Li ◽  
Yanbao Zhao
Keyword(s):  
Drug Release ◽  
Silica Nanoparticles ◽  
Porous Silica ◽  
Dual Responsive

scholarly journals Fullerenol-Capped Porous Silica Nanoparticles for pH-Responsive Drug Delivery

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Nikola Ž. Knežević ◽  
Sanja Milenković ◽  
Danica Jović ◽  
Slavica Lazarevic ◽  
Jasminka Mrdjanović ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Thermogravimetric Analysis ◽  
Drug Release ◽  
Silica Nanoparticles ◽  
Porous Silica ◽  
Targeted Treatment ◽  
Capping Agent ◽  
Ph Responsive ◽  
Tumor Tissues ◽  
Acidic Conditions

Novel nanocomposite containing fullerenol nanoparticles (FNP) and porous silica nanoparticles (PSNs) was constructed and characterized. The capability of FNP to serve as a pore-capping agent and for entrapping 9-aminoacridine (9-AA) inside the pores of the PSN material was also demonstrated. Nitrogen sorption measurements evidence the successful capping of the silica pores while thermogravimetric analysis of FNP loaded PSN indicates the existence of pore-loaded fullerenol molecules. Higher amount of the drug release was noted by exposing the material to weakly acidic conditions in comparison to physiological pH, which may find application in targeted treatment of weakly acidic tumor tissues.

Fabrication of autofluorescent porous silica nanoparticles for redox-responsive drug release

2016 ◽  
Vol 69 ◽  
pp. 330-336 ◽  
Author(s):  
Na Cao ◽  
Yanbao Zhao ◽  
Bin Sang ◽  
Zhihua Wang ◽  
Liuqin Cao ◽  
...  
Keyword(s):  
Drug Release ◽  
Silica Nanoparticles ◽  
Porous Silica ◽  
Redox Responsive

scholarly journals Functional polymeric dialdehyde dextrin network capped mesoporous silica nanoparticles for pH/GSH dual-controlled drug release

RSC Advances ◽  
2018 ◽  
Vol 8 (37) ◽  
pp. 20862-20871 ◽  
Author(s):  
Chao Chen ◽  
Wen Sun ◽  
Wenji Yao ◽  
Yibing Wang ◽  
Hanjie Ying ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Disulfide Bond ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release ◽  
Polymer Shell ◽  
Dual Responsive

A smart pH/GSH dual-responsive drug delivery system by using DAD as a “gatekeeper polymer” to end-cap MSNs via pH-sensitive Schiff bond, whereas DAD polymer shell were cross-linked by GSH-sensitive disulfide bond.

Allantoin-loaded porous silica nanoparticles/polycaprolactone nanofiber composites: fabrication, characterization, and drug release properties

RSC Advances ◽  
2016 ◽  
Vol 6 (6) ◽  
pp. 4593-4600 ◽  
Author(s):  
Ma Ke ◽  
Jatoi Abdul Wahab ◽  
Bang Hyunsik ◽  
Kyung-Hun Song ◽  
Jung Soon Lee ◽  
...  
Keyword(s):  
Drug Release ◽  
Silica Nanoparticles ◽  
Biomedical Applications ◽  
Porous Silica

The development of biocompatible nanocomposites for biomedical applications such as drug release has attracted increasing attention in recent years.

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