Activation of Wnt-β-catenin pathway in basal–parabasal layers of normal cervical epithelium comparable during development of uterine cervical carcinoma

2017 ◽  
Vol 443 (1-2) ◽  
pp. 121-130 ◽  
Author(s):  
Chandraditya Chakraborty ◽  
Sudip Samadder ◽  
Anirban Roychowdhury ◽  
Anup Roy ◽  
Pradip Das ◽  
...  
Keyword(s):  
Cervical Carcinoma ◽  
Cervical Epithelium ◽  
Uterine Cervical Carcinoma ◽  
Normal Cervical Epithelium

scholarly journals Deregulation of LIMD1–VHL–HIF-1α–VEGF pathway is associated with different stages of cervical cancer

2018 ◽  
Vol 475 (10) ◽  
pp. 1793-1806 ◽  
Author(s):  
Chandraditya Chakraborty ◽  
Sraboni Mitra ◽  
Anirban Roychowdhury ◽  
Sudip Samadder ◽  
Sankhadeep Dutta ◽  
...  
Keyword(s):  
Protein Expression ◽  
Cell Lines ◽  
Cervical Carcinoma ◽  
Promoter Methylation ◽  
Intraepithelial Neoplasia ◽  
Cervical Epithelium ◽  
Human Papillomavirus 16 ◽  
Expression Of Genes ◽  
Normal Cervix ◽  
Normal Cervical Epithelium

To understand the mechanism of cellular stress in basal–parabasal layers of normal cervical epithelium and during different stages of cervical carcinoma, we analyzed the alterations (expression/methylation/copy number variation/mutation) of HIF-1α and its associated genes LIMD1, VHL and VEGF in disease-free normal cervix (n = 9), adjacent normal cervix of tumors (n = 70), cervical intraepithelial neoplasia (CIN; n = 32), cancer of uterine cervix (CACX; n = 174) samples and two CACX cell lines. In basal–parabasal layers of normal cervical epithelium, LIMD1 showed high protein expression, while low protein expression of VHL was concordant with high expression of HIF-1α and VEGF irrespective of HPV-16 (human papillomavirus 16) infection. This was in concordance with the low promoter methylation of LIMD1 and high in VHL in the basal–parabasal layers of normal cervix. LIMD1 expression was significantly reduced while VHL expression was unchanged during different stages of cervical carcinoma. This was in concordance with their frequent methylation during different stages of this tumor. In different stages of cervical carcinoma, the expression pattern of HIF-1α and VEGF was high as seen in basal–parabasal layers and inversely correlated with the expression of LIMD1 and VHL. This was validated by demethylation experiments using 5-aza-2′-deoxycytidine in CACX cell lines. Additional deletion of LIMD1 and VHL in CIN/CACX provided an additional growth advantage during cervical carcinogenesis through reduced expression of genes and associated with poor prognosis of patients. Our data showed that overexpression of HIF-1α and its target gene VEGF in the basal–parabasal layers of normal cervix was due to frequent inactivation of VHL by its promoter methylation. This profile was maintained during different stages of cervical carcinoma with additional methylation/deletion of VHL and LIMD1.

MR imaging of uterine cervical carcinoma: comparison between fast spin-echo MRI and GRASE

1998 ◽  
Vol 8 (1) ◽  
pp. 45-49 ◽  
Author(s):  
S. Postema ◽  
P. M. T. Pattynama ◽  
C. S. P. van Rijswijk ◽  
A. van Erkel ◽  
E. R. Tjin A Ton
Keyword(s):  
Mr Imaging ◽  
Cervical Carcinoma ◽  
Spin Echo ◽  
Fast Spin Echo ◽  
Uterine Cervical Carcinoma ◽  
Fast Spin

Mitotic Index and Ki-67 Nuclear Antigen Labeling Index as Predictors of Chemotherapy Response in Uterine Cervical Carcinoma

2001 ◽  
Vol 83 (3) ◽  
pp. 555-559 ◽  
Author(s):  
Seiryu Kamoi ◽  
Yoshiharu Ohaki ◽  
Susumu Okada ◽  
Norihiro Matsushita ◽  
Takashi Kawamura ◽  
...  
Keyword(s):  
Mitotic Index ◽  
Cervical Carcinoma ◽  
Labeling Index ◽  
Nuclear Antigen ◽  
Chemotherapy Response ◽  
Ki 67 ◽  
Uterine Cervical Carcinoma

Cellulitis-like cutaneous metastasis of uterine cervical carcinoma

2007 ◽  
Vol 56 (2) ◽  
pp. S26-S28 ◽  
Author(s):  
Hsin-I. Yang ◽  
Mei-Ching Lee ◽  
Tseng-Tong Kuo ◽  
Hong-Shang Hong
Keyword(s):  
Cervical Carcinoma ◽  
Cutaneous Metastasis ◽  
Uterine Cervical Carcinoma

scholarly journals Localized in vivo 1H nuclear MR spectroscopy for evaluation of human uterine cervical carcinoma.

1998 ◽  
Vol 170 (5) ◽  
pp. 1279-1282 ◽  
Author(s):  
J H Lee ◽  
K S Cho ◽  
Y M Kim ◽  
S T Kim ◽  
C W Mun ◽  
...  
Keyword(s):  
Cervical Carcinoma ◽  
Mr Spectroscopy ◽  
Uterine Cervical Carcinoma
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