Tyrosine inhibits creatine kinase activity in cerebral cortex of young rats

2011 ◽  
Vol 26 (3) ◽  
pp. 221-227 ◽  
Author(s):  
Rodrigo Binkowski de Andrade ◽  
Tanise Gemelli ◽  
Denise Bertin Rojas ◽  
Cláudia Funchal ◽  
Carlos Severo Dutra-Filho ◽  
...  
2010 ◽  
Vol 30 (6) ◽  
pp. 611-616 ◽  
Author(s):  
Rodrigo Binkowski de Andrade ◽  
Tanise Gemelli ◽  
Robson Brum Guerra ◽  
Cláudia Funchal ◽  
Clovis Milton Duval Wannmacher

2009 ◽  
Vol 24 (2) ◽  
pp. 349-360 ◽  
Author(s):  
Anelise Miotti Tonin ◽  
Gustavo Costa Ferreira ◽  
Patrícia Fernanda Schuck ◽  
Carolina Maso Viegas ◽  
Ângela Zanatta ◽  
...  

2016 ◽  
Vol 94 (5) ◽  
pp. 451-458 ◽  
Author(s):  
Morgana Prá ◽  
Gabriela Kozuchovski Ferreira ◽  
Aline Haas de Mello ◽  
Rosiane de Bona Schraiber ◽  
Larissa Colonetti Cardoso ◽  
...  

Liraglutide is a human glucagon-like peptide-1 (GLP-1) analogue that was recently approved to treat obesity in some countries. Considering that liraglutide effects on brain energy metabolism are little known, we evaluated the effects of liraglutide on the energy metabolism. Animals received a single or daily injection of saline or liraglutide during 7 days (25, 50, 100, or 300 μg/kg i.p.). Twenty-four hours after the single or last injection, the rats were euthanized and the hypothalamus, prefrontal cortex, cerebellum, hippocampus, striatum, and posterior cortex were isolated. Our results demonstrated that a single dose of liraglutide in young rats increased the activity of complexes and inhibited creatine kinase activity. Repeated administrations of liraglutide in young rats reduced the activity of complexes and activated creatine kinase activity. In adult rats, a single dose of liraglutide reduced the activity of complex I and creatine kinase and increased the activity of complexes II and IV. Repeated administrations of liraglutide in adult rats increased the activity of complexes I and IV and reduced the activity of complex II and creatine kinase. We concluded that liraglutide may interfere in energy metabolism, because analysis of different times of administrations, concentrations, and level of brain development leads to divergent results.


2003 ◽  
Vol 33 (10) ◽  
pp. 840-847 ◽  
Author(s):  
C. G. Da Silva ◽  
A. R. F. Bueno ◽  
P. F. Schuck ◽  
G. Leipnitz ◽  
C. A. J. Ribeiro ◽  
...  

2006 ◽  
Vol 60 (2) ◽  
pp. 190-195 ◽  
Author(s):  
Virginia Cielo Rech ◽  
Genaro Azambuja Athaydes ◽  
Luciane Rosa Feksa ◽  
Paula Karine Barcelos Dornelles ◽  
Valnes Rodrigues-Junior ◽  
...  

2003 ◽  
Vol 21 (2) ◽  
pp. 111-116 ◽  
Author(s):  
Elisa Costabeber ◽  
Adriana Kessler ◽  
Carlos Severo Dutra‐Filho ◽  
Angela Terezinha Souza Wyse ◽  
Moacir Wajner ◽  
...  

Neonatology ◽  
1979 ◽  
Vol 36 (3-4) ◽  
pp. 160-167 ◽  
Author(s):  
H.J. Kloosterboer ◽  
H. van Faassen ◽  
S.A. Stoker-de Vries ◽  
F.A. Hommes

2012 ◽  
Vol 50 (10) ◽  
pp. 3468-3474 ◽  
Author(s):  
Rodrigo Binkowski de Andrade ◽  
Tanise Gemelli ◽  
Robson Brum Guerra ◽  
Cláudia Funchal ◽  
Clovis Milton Duval Wannmacher

2006 ◽  
Vol 1124 (1) ◽  
pp. 188-196 ◽  
Author(s):  
Andrea Renata Cornelio ◽  
Valnês da Silva Rodrigues-Junior ◽  
Virginia Cielo Rech ◽  
Angela Terezinha de Souza Wyse ◽  
Carlos Severo Dutra-Filho ◽  
...  

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