Altered urinary porphyrins and mercury exposure as biomarkers for autism severity in Egyptian children with autism spectrum disorder

Autism is characterized by dysfunction in motor execution and sensory perception that are linked with neuromuscular function (fN) for children with autism spectrum disorder (ASD). This article aims to evaluate effectiveness of yoga therapy (YT) on fN and autism severity in children with ASD. Sixty children were screened (age 6 to 18) using childhood autism rating scale (CARS); 40 were allocated randomly (n=20) into yoga (YG) and control (CG) groups; both followed regular school routine, and YG received 10 YT sessions (60 min/session). Visual reaction time (VRT), handgrip strength (HGS), and CARS were measured. YG showed significant changes in VRT and CARS after YT and intergroup comparisons revealed significant differences between groups at the end of the study (VRT,p=0.008; CARS,p=0.011). YT resulted in small but statistically significant changes in CARS and significant improvement in VRT. This implies that YT can be used as an adjuvant modality for children with ASD, reducing co-morbidities with regard to the neuromuscular function.

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SERUM ANTIGLIADIN ANTIBODIES IN EGYPTIAN CHILDREN WITH AUTISM SPECTRUM DISORDER: RELATIONSHIP TO GASTROINTESTINAL SYMPTOMS, BEHAVIORAL AND SOCIAL COMMUNICATIONS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i4.22723 ◽

2018 ◽

Vol 11 (4) ◽

pp. 355

Author(s):

Inas R El-alameey ◽

Hanaa H Ahmed ◽

Ihab M Eid ◽

Ghada El-dory ◽

Manal Gameel

Keyword(s):

Autism Spectrum Disorder ◽

Gastrointestinal Symptoms ◽

Children With Autism ◽

Serum Levels ◽

Autism Spectrum ◽

High Serum ◽

Spectrum Disorder ◽

Gliadin Antibodies ◽

Gi Symptoms ◽

Egyptian Children

Objectives: Gastrointestinal symptoms are major characteristic in children with autism spectrum disorder (ASD), drawing attention to a potent association with gluten sensitivity. The goal of this study was to evaluate anti-gliadin antibodies serum levels in a group of Egyptian children with ASDs and to address the potential link to gastrointestinal (GI) symptoms, behavioral, and social communications.Patients and Methods: This descriptive case–control study included 45 children diagnosed as ASD according to Diagnostic and Statistical Manual of Mental Disorders 5th Edition and a history of GI symptoms, compared with 45 apparently healthy children of matched age and sex. Serum anti-gliadin antibodies were measured using enzyme-linked immunosorbent assay kits.Results: Serum levels of IgM, IgA, and IgG class antibodies to gliadin showed a significant increase compared to healthy controls (p<0.000). Multiple logistic regression analysis showed a significant association between the high serum levels of IgA and IgM class antibodies to gliadin in the studied patients and GI symptoms (p<0.05). A significant association was detected between the high serum levels of IgG antibodies to gliadin and the behavior symptoms (p<0.05).Conclusions: The anti-gliadin antibody response and its association with GI symptoms indicated the involvement of abnormal immunologic intestinal permeability in affected children. Immune system of some autistic patients could be abnormally triggered by gluten assumption.

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