Protective effect of tropisetron on high glucose induced apoptosis and oxidative stress in PC12 cells: roles of JNK, P38 MAPKs, and mitochondria pathway

2017 ◽  
Vol 32 (3) ◽  
pp. 819-826 ◽  
Author(s):  
Azadeh Aminzadeh
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Pc12 Cells ◽  
High Glucose ◽  
Mitochondria Pathway ◽  
Induced Apoptosis ◽  
And Oxidative Stress ◽  
P38 Mapks

scholarly journals Protective effect of nobiletin on isolated human islets survival and function against hypoxia and oxidative stress-induced apoptosis

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Somayeh Keshtkar ◽  
Maryam Kaviani ◽  
Zahra Jabbarpour ◽  
Bita Geramizadeh ◽  
Elahe Motevaseli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Human Islets ◽  
Induced Apoptosis ◽  
And Function ◽  
And Oxidative Stress

Attenuation of aldose reductase gene suppresses high-glucose-induced apoptosis and oxidative stress in rat lens epithelial cells

2008 ◽  
Vol 82 (1) ◽  
pp. 18-24 ◽  
Author(s):  
Hirotaka Nambu ◽  
Eri Kubo ◽  
Yoshihiro Takamura ◽  
Shosai Tsuzuki ◽  
Miyuki Tamura ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Epithelial Cells ◽  
Aldose Reductase ◽  
High Glucose ◽  
Lens Epithelial Cells ◽  
Reductase Gene ◽  
Induced Apoptosis ◽  
And Oxidative Stress

Cyanide-Induced Apoptosis and Oxidative Stress in Differentiated PC12 Cells

2002 ◽  
Vol 67 (3) ◽  
pp. 1039-1046 ◽  
Author(s):  
Edward M. Mills ◽  
Palur G. Gunasekar ◽  
Goran Pavlakovic ◽  
Gary E. Isom
Keyword(s):  
Oxidative Stress ◽  
Pc12 Cells ◽  
Differentiated Pc12 Cells ◽  
Induced Apoptosis ◽  
And Oxidative Stress

scholarly journals Burdock Fructooligosaccharide Attenuates High Glucose-Induced Apoptosis and Oxidative Stress Injury in Renal Tubular Epithelial Cells

2021 ◽  
Vol 12 ◽  
Author(s):  
Mengru Ding ◽  
Zhiyan Tang ◽  
Wei Liu ◽  
Taili Shao ◽  
Pingchuan Yuan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Epithelial Cells ◽  
High Glucose ◽  
Tubular Epithelial Cells ◽  
Renal Tubular Epithelial Cells ◽  
Stress Injury ◽  
Oxidative Stress Injury ◽  
Renal Tubular ◽  
Induced Apoptosis ◽  
And Oxidative Stress

Hyperglycemia-induced apoptosis and oxidative stress injury are thought to play important roles in the pathogenesis of diabetic nephropathy (DN). Attenuating high glucose (HG)-induced renal tubular epithelial cell injury has become a potential approach to ameliorate DN. In recent years, burdock fructooligosaccharide (BFO), a water-soluble inulin-type fructooligosaccharide extracted from burdock root, has been shown to have a wide range of pharmacological activities, including antiviral, anti-inflammatory, and hypolipidemic activities. However, the role and mechanism of BFO in rat renal tubular epithelial cells (NRK-52E cells) have rarely been investigated. The present study investigated the protective effect of BFO on HG-induced damage in NRK-52E cells. BFO could protect NRK-52E cells against the reduced cell viability and significantly increased apoptosis rate induced by HG. These anti-oxidative stress effects of BFO were related to the significant inhibition of the production of reactive oxygen species, stabilization of mitochondrial membrane potential, and increased antioxidant (superoxide dismutase and catalase) activities. Furthermore, BFO increased the expression of Nrf2, HO-1, and Bcl-2 and decreased the expression of Bax. In conclusion, these findings suggest that BFO protects NRK-52E cells against HG-induced damage by inhibiting apoptosis and oxidative stress through the Nrf2/HO-1 signaling pathway.

scholarly journals The Protective Effect of Aspirin Eugenol Ester on Oxidative Stress to PC12 Cells Stimulated with H2O2 through Regulating PI3K/Akt Signal Pathway

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Zhen-Dong Zhang ◽  
Ya-Jun Yang ◽  
Xi-Wang Liu ◽  
Zhe Qin ◽  
Shi-Hong Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Pc12 Cells ◽  
Caspase 3 ◽  
Signal Pathway ◽  
Control Group ◽  
Cell Viability Assay ◽  
Viability Assay ◽  
Induced Apoptosis ◽  
Aspirin Eugenol Ester

Aspirin eugenol ester (AEE) is a new pharmaceutical compound esterified by aspirin and eugenol, which has anti-inflammatory, antioxidant, and other pharmacological activities. This study is aimed at identifying the protective effect of AEE against H2O2-induced apoptosis in rat adrenal pheochromocytoma PC12 cells and the possible mechanisms. The results of cell viability assay showed that AEE could increase the viability of PC12 cells stimulated by H2O2, while AEE alone had no significant effect on the viability of PC12 cells. Compared with the control group, the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) were significantly decreased, and the content of malondialdehyde (MDA) was significantly increased in the H2O2 group. By AEE pretreatment, the level of MDA was reduced and the levels of SOD, CAT, and GSH-Px were increased in H2O2-stimulated PC12 cells. In addition, AEE could reduce the apoptosis of PC12 cells induced by H2O2 via reducing superoxide anion, intracellular ROS, and mitochondrial ROS (mtROS) and increasing the levels of mitochondrial membrane potential (ΔΨm). Furthermore, the results of western blotting showed that compared with the control group, the expression of p-PI3K, p-Akt, and Bcl-2 was significantly decreased, while the expression of Caspase-3 and Bax was significantly increased in the H2O2 group. In the AEE group, AEE pretreatment could upregulate the expression of p-PI3K, p-Akt, and Bcl-2 and downregulate the expression of Caspase-3 and Bax in PC12 cells stimulated with H2O2. The silencing of PI3K with shRNA and its inhibitor-LY294002 could abrogate the protective effect of AEE in PC12 cells. Therefore, AEE has a protective effect on H2O2-induced PC12 cells by regulating the PI3K/Akt signal pathway to inhibit oxidative stress.

Neuronal Cell Protective Effect of Dendropanax morbifera Extract against High Glucose-Induced Oxidative Stress

2016 ◽  
Vol 45 (7) ◽  
pp. 938-947 ◽  
Author(s):  
Jong Min Kim ◽  
Seon Kyeong Park ◽  
Tian Jiao Guo ◽  
Jin Yong Kang ◽  
Jeong Su Ha ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
High Glucose ◽  
Neuronal Cell ◽  
Dendropanax Morbifera ◽  
Dendropanax Morbifera Extract
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