Synthesis and characterization of gadolinium nanosheets with bound rose bengal: potential use in photodynamic therapy and MRI

2014 ◽  
Vol 16 (11) ◽  
Author(s):  
Dimitrios Stefanakis ◽  
Ioannis Seimenis ◽  
Demetrios Ghanotakis
Keyword(s):  
Photodynamic Therapy ◽  
Rose Bengal ◽  
Synthesis And Characterization ◽  
Potential Use

New peripherally substituted lutetium mono and bis phthalocyanines: Synthesis and comparative photophysical and photochemical properties

2019 ◽  
Vol 23 (11n12) ◽  
pp. 1542-1550
Author(s):  
Nagihan Kocaağa ◽  
Öznur Dülger Kutlu ◽  
Ali Erdoğmuş
Keyword(s):  
Mass Spectrometry ◽  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Photophysical Properties ◽  
Quantum Yields ◽  
Synthesis And Characterization ◽  
Type Ii ◽  
H Nmr ◽  
Photochemical Properties

In this study, the synthesis and characterization of mono-(phthalocyaninato) lutetium(III) (1-Cl and 1-F) [Lu[Formula: see text](AcO)(Pc)] (Pc [Formula: see text] phthalocyaninato, AcO [Formula: see text] acetate) and bis-(phthalocyaninato) lutetium(III) (2-Cl and 2-Br) [Lu[Formula: see text]Pc[Formula: see text]] bearing halogenated (F, Cl and Br) phenoxy–phenoxy groups are described and verified by IR, [Formula: see text]H-NMR, UV-vis and mass spectrometry. Photochemical and photophysical properties of 1-F, 1-Cl 2-Cl and 2-Br in DMSO are also presented. A comparison between photophysical and photochemical parameters of mono and bis derivatives showed that mono phthalocyanines are better photosensitizers than bis phthalocyanines. Photophysical and photochemical properties of phthalocyanines are very useful for photodynamic therapy applications. Singlet oxygen quantum yields [Formula: see text] give an indication of the potential of the complexes as photosensitizers in photodynamic therapy applications. The chloro, fluoro, bromo-phenoxy–phenoxy substituted mono-(phthalocyaninato) lutetium(III) complexes (1-Cl and 1-F) gave good singlet oxygen quantum yields (from 0.86 to 0.80) in DMSO. Thus, these complexes show potential as Type II photosensitizers for PDT of cancer.

Synthesis and characterization of a new natural product analog, 132-173-bacteriochlorophyllone a

2014 ◽  
Vol 18 (03) ◽  
pp. 188-199 ◽  
Author(s):  
Áron Roxin ◽  
Thomas D. MacDonald ◽  
Gang Zheng
Keyword(s):  
Antioxidant Activity ◽  
Biological Activity ◽  
Photodynamic Therapy ◽  
Natural Product ◽  
Synthesis And Characterization ◽  
Facile Synthesis ◽  
H Nmr ◽  
F Ring ◽  
C Nmr

Here we show the facile synthesis of 132-173-bacteriochlorophyllone a (12), with a distinct seven-membered exocyclic F-ring formed by 132-173-cyclization of bacteriopheophorbide a(16). This is the latest reported bacteriochlorin with such an exocyclic F-ring since 1975 (132-173 cyclobacteriopheophorbide a-enol, 11), and is an analog of previously described natural exocyclic F-ring-containing porphyrins (1–4) and chlorins (5–10). The structure of 12 was confirmed using a combination of 1D 1 H NMR, 2D COSY 1 H NMR, Jmod 13 C NMR and HRMS analysis. The biological activity of 12 was explored, and we found that this compound does not possess strong antioxidant activity like its natural product counterparts, but is a capable photosensitizer for photodynamic therapy.

Synthesis and characterization of graphene-based nanocomposites with potential use for biomedical applications

2013 ◽  
Vol 15 (3) ◽  
Author(s):  
Daniele Nuvoli ◽  
Valeria Alzari ◽  
Roberta Sanna ◽  
Sergio Scognamillo ◽  
Jenny Alongi ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Synthesis And Characterization ◽  
Potential Use

Photophysical, photooxidation, and biomolecule-interaction of meso-tetra(thienyl)porphyrins containing peripheral Pt(II) and Pd(II) complexes. Insights for photodynamic therapy applications

2022 ◽  
Author(s):  
Isadora Tisoco ◽  
Maria Carolina Donatoni ◽  
Henrique Victória ◽  
José Roberto de Toledo ◽  
Klaus Krambrock ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Elemental Analysis ◽  
Synthesis And Characterization ◽  
Polypyridyl Complexes ◽  
Cationic Porphyrins ◽  
Peripheral Position

We report the synthesis and characterization of two novel tetra-cationic porphyrins, containing Pt(II) or Pd(II) polypyridyl complexes attached at the peripheral position of N4-macrocycle. Compounds were characterized through elemental analysis,...

Synthesis and Characterization of Oxazine-doped Silica Nanoparticles for Their Potential Use as Stable Fluorescent Reagents

2009 ◽  
Vol 20 (1) ◽  
pp. 171-180 ◽  
Author(s):  
Juan Godoy-Navajas ◽  
Maria-Paz Aguilar-Caballos ◽  
Agustina Gómez-Hens
Keyword(s):  
Silica Nanoparticles ◽  
Synthesis And Characterization ◽  
Potential Use
Sign in / Sign up

Export Citation Format

Share Document