Central nervous system blastic crisis in chronic myeloid leukemia on imatinib mesylate therapy: a case report

2007 ◽  
Vol 84 (1) ◽  
pp. 103-105 ◽  
Author(s):  
Abdullah Altintas ◽  
Timucin Cil ◽  
Ilhan Kilinc ◽  
Muhammet Ali Kaplan ◽  
Orhan Ayyildiz
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Chronic Myeloid Leukemia ◽  
Imatinib Mesylate ◽  
Myeloid Leukemia ◽  
Blastic Crisis

scholarly journals Central Nervous System Blast Crisis in Chronic Myeloid Leukemia on Imatinib Mesylate Therapy: Report of Two Cases

2011 ◽  
Vol 27 (1) ◽  
pp. 51-54 ◽  
Author(s):  
Narayan Radhika ◽  
Mishra Minakshi ◽  
Mohanty Rajesh ◽  
Baisakh R. Manas ◽  
Mishra Deepak Kumar
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Chronic Myeloid Leukemia ◽  
Imatinib Mesylate ◽  
Myeloid Leukemia ◽  
Blast Crisis

scholarly journals Isolated central nervous system blast crisis in a case of chronic myeloid leukemia on dasatinib

2018 ◽  
Vol 07 (03) ◽  
pp. 170-187 ◽  
Author(s):  
P.K Kiran ◽  
Girish V. Badarke ◽  
C.N Suresh ◽  
B.J Srinivas ◽  
Radheshyam Naik
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Blast Crisis

Isolated Central Nervous System Blast Crisis of Chronic Myeloid Leukemia with Dasatinib Therapy

2021 ◽  
Vol 67 (02/2021) ◽  
Author(s):  
Yi Dong ◽  
Jia Wang ◽  
Yuanyuan Shen ◽  
Qing Zhang ◽  
Zhimin Zhai ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Chronic Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Blast Crisis

Is it possible to discontinue imatinib mesylate therapy in Chronic Myeloid Leukemia patients with undetectable BCR/ABL? A case report and a review of the literature

2009 ◽  
Vol 33 (8) ◽  
pp. 1079-1081 ◽  
Author(s):  
Salvatore Guastafierro ◽  
Umberto Falcone ◽  
Maria Celentano ◽  
Milena Coppola ◽  
Maria Giovanna Ferrara ◽  
...  
Keyword(s):  
Case Report ◽  
Chronic Myeloid Leukemia ◽  
Imatinib Mesylate ◽  
Myeloid Leukemia ◽  
Review Of The Literature

scholarly journals An Atypical Initial Presentation of Chronic Myeloid Leukemia with Central Nervous System and Lymph Node Blast Crises

2016 ◽  
Vol 9 (2) ◽  
pp. 415-421 ◽  
Author(s):  
Khadega A. Abuelgasim ◽  
Saeed Alshieban ◽  
Nada A. Almubayi ◽  
Ayman Alhejazi ◽  
Abdulrahman R. Jazieh
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Nervous System ◽  
Chronic Myeloid Leukemia ◽  
Peripheral Blood ◽  
Myeloid Leukemia ◽  
Single Agent ◽  
Chronic Phase ◽  
Current Evidence ◽  
Molecular Response

We describe the case of a young man with therapy-naive chronic myeloid leukemia who did not initially have any peripheral blood or bone marrow excess blasts but presented with extramedullary myeloid blast crises involving the central nervous system and multiple lymph nodes. Conventional cytogenetic tests were positive for t(9;22)(q34:q11) as well as for trisomy 8, 14 and 21 and del(16q). The patient’s peripheral blood and bone marrow were positive for the BCR-ABL oncogene when analyzed by fluorescence in situ hybridization and polymerase chain reaction. He achieved good clinical, radiological, cytogenetic and molecular response to acute myeloid leukemia induction chemotherapy combined with 16 doses of triple intrathecal chemotherapy and oral dasatinib (second-generation tyrosine kinase inhibitor) treatment. Due to his poor general condition, he was treated with 24 Gy of whole-brain radiation therapy, as allogeneic stem cell transplantation was not feasible. Although extramedullary CNS blast crises are usually associated with a very poor outcome, our patient remains in complete cytogenetic and molecular remission, on single-agent dasatinib, 4 years after the diagnosis with no current evidence of active extramedullary disease. This suggests that dasatinib has a role in controlling not only chronic-phase chronic myeloid leukemia, but also its CNS blast crisis.

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