A systematic review and meta-analysis of supratotal versus gross total resection for glioblastoma

2020 ◽  
Vol 148 (3) ◽  
pp. 419-431 ◽  
Author(s):  
Christina Jackson ◽  
John Choi ◽  
Adham M. Khalafallah ◽  
Carrie Price ◽  
Chetan Bettegowda ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Gross Total Resection ◽  
Total Resection

scholarly journals SURG-16. SUPRATOTAL VERSUS GROSS TOTAL RESECTION OF GLIOBLASTOMA: A SYSTEMATIC REVIEW

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi243-vi243
Author(s):  
Christina Jackson ◽  
John Choi ◽  
Carrie Price ◽  
Chetan Bettegowda ◽  
Michael Lim ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Gross Total Resection ◽  
Cochrane Library ◽  
Study Quality ◽  
Total Resection ◽  
Significant Difference ◽  
Definition Of ◽  
Supratotal Resection ◽  
The Cochrane Library

Abstract INTRODUCTION Due to the infiltrative nature of glioblastoma(GBM) outside of the contrast enhancing region in the peritumoral zone, there is increasing movement to perform supratotal resections (SpTR) by extending the edge of resection beyond the contrast enhancing portion of the tumor. However, there is currently no consensus on the potential survival benefit of SpTR in GBM as compared to gross total resection (GTR). METHODS Therefore, we performed a systematic review using PRISMA guidelines and performed a comprehensive literature search on Pubmed, EMBASE, The Cochrane Library, Web of Science, Scopus, and ClinicalTrials.gov, from inception to August 16, 2018, to identify articles comparing overall survival (OS) after SpTR versus GTR. Furthermore, we assessed study quality using the Oxford Centre for Evidence-Based Medicine guidelines. RESULTS We identified 8902 unique citations, of which 11 articles and 2 abstracts met study inclusion criteria. 925 patients underwent SpTR out of a total of 2137 patients. 9 of the 13 studies demonstrated improved survival with SpTR compared to GTR (median improvement in OS of 10.5 months), with no significant difference in post-operative complication rate. Conversely, one abstract found worsened outcomes with SpTR compared to GTR (median decrease in OS of 4 months). However, overall study quality was poor, with 12 of the 13 studies of level IV evidence and one study of level IIIb evidence. We were unable to perform a meta-analysis due to significant clinical and methodological heterogeneity amongst the studies (e.g. differences in adjuvant therapy and lack of standardization of definition of supratotal resection). CONCLUSIONS Our systematic review indicates that SpTR may be associated with improved OS compared to GTR for GBM. However, this is limited by poor study quality and significant clinical and methodological heterogeneity amongst the studies. There is need for prospective clinical trials to further establish standardized guidelines for SpTR in GBM.

Endocrine and Visual Outcomes Following Gross Total Resection and Subtotal Resection of Adult Craniopharyngioma: Systematic Review and Meta-Analysis

2019 ◽  
Vol 127 ◽  
pp. e656-e668 ◽  
Author(s):  
Oluwaseun O. Akinduro ◽  
Alessandro Izzo ◽  
Victor M. Lu ◽  
Luca Ricciardi ◽  
Daniel Trifiletti ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Gross Total Resection ◽  
Subtotal Resection ◽  
Total Resection ◽  
Visual Outcomes

Biopsy Versus Subtotal Versus Gross Total Resection in Patients with Low-Grade Glioma: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 120 ◽  
pp. e762-e775 ◽  
Author(s):  
Kaiyun Yang ◽  
Siddharth Nath ◽  
Alex Koziarz ◽  
Jetan H. Badhiwala ◽  
Huphy Ghayur ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Low Grade Glioma ◽  
Gross Total Resection ◽  
Low Grade ◽  
Total Resection

Gross total resection with fluorescence could lead to improved overall survival rates: a systematic review and meta-analysis

2021 ◽  
pp. 1-7
Author(s):  
Alexandrina S. Nikova ◽  
Penelope Vlotinou ◽  
Loukas Karelis ◽  
Michael Karanikas ◽  
Theodossios A. Birbilis
Keyword(s):  
Systematic Review ◽  
Overall Survival ◽  
Meta Analysis ◽  
Survival Rates ◽  
Gross Total Resection ◽  
Total Resection ◽  
Overall Survival Rates

scholarly journals Biopsy versus partial versus gross total resection in older patients with high-grade glioma: a systematic review and meta-analysis

2015 ◽  
Vol 17 (6) ◽  
pp. 868-881 ◽  
Author(s):  
S. A. Almenawer ◽  
J. H. Badhiwala ◽  
W. Alhazzani ◽  
J. Greenspoon ◽  
F. Farrokhyar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Older Patients ◽  
Meta Analysis ◽  
High Grade Glioma ◽  
Gross Total Resection ◽  
High Grade ◽  
Total Resection

Recurrence of Rathke’s Cleft Cysts Based on Gross Total Resection of Cyst Wall: A Meta-analysis

2020 ◽  
Author(s):  
Victor Lu ◽  
Avital Perry ◽  
Christopher Graffeo ◽  
Krishnan Ravindran ◽  
Jamie Van Gompel
Keyword(s):  
Cyst Wall ◽  
Meta Analysis ◽  
Gross Total Resection ◽  
Total Resection ◽  
Rathke's Cleft Cysts ◽  
Rathke's Cleft

Recurrence of Rathke’s cleft cysts based on gross total resection of cyst wall: a meta-analysis

2019 ◽  
Vol 43 (3) ◽  
pp. 957-966 ◽  
Author(s):  
Victor M. Lu ◽  
Krishnan Ravindran ◽  
Avital Perry ◽  
Christopher S. Graffeo ◽  
Hassan Y. Dawood ◽  
...  
Keyword(s):  
Cyst Wall ◽  
Meta Analysis ◽  
Gross Total Resection ◽  
Total Resection ◽  
Rathke's Cleft Cysts ◽  
Rathke's Cleft

scholarly journals P.041 Adult craniopharyngioma: case series, systematic review and meta-analysis

2017 ◽  
Vol 44 (S2) ◽  
pp. S24-S24
Author(s):  
C Dandurand ◽  
AA Sepehry ◽  
MH Asadi Lari ◽  
R Akagami ◽  
PA Gooderham
Keyword(s):  
Meta Analysis ◽  
Case Series ◽  
Gross Total Resection ◽  
Subtotal Resection ◽  
Total Resection ◽  
Childhood Population ◽  
Institutional Experience ◽  
The Difference ◽  
Meta Analyses ◽  
Case Basis

Background: The optimal therapeutic approach for adult craniopharyngioma remains controversial. Some advocate for gross total resection (GTR), while others support subtotal resection followed by adjuvant radiotherapy (STR + XRT). Methods: MEDLINE (1946 to July 1st 2016) and EMBASE (1980 to June 30th 2016) were systematically reviewed. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed. At our institution, from 1975 to 2013, 33 patients were treated with initial surgical resection for adult onset craniopharyngioma. 22 patients were included in the present case series. Results: Eligible studies (n=21) were identified from the literature in addition to a case series of our institutional experience. Three groups were available for analysis: GTR, STR + XRT, and STR. The rates of recurrence were 17 %, 27 % and 45%, respectively. This differs from childhood population. The difference in risk of recurrence after GTR vs. STR + XRT did not reach significance (OR: 0.63, 95% confidence interval: 0.33-1.24, P=0.18). This maybe because of low pooled sample size (n=99) who underwent STR+XRT. Conclusions: This is the first and largest meta-analysis examining rate of recurrence in adult craniopharyngioma. Thus, when safe and feasible, a goal of gross total resection should be favored. Each patient should be considered on a case-by-case basis.

Central Neurocytoma Treatment Modalities: A Systematic Review Assessing the Outcomes of Combined Maximal Safe Resection and Radiotherapy with Gross Total Resection

2020 ◽  
Vol 137 ◽  
pp. e176-e182 ◽  
Author(s):  
Anil K. Mahavadi ◽  
Priyen M. Patel ◽  
Manish Kuchakulla ◽  
Ashish H. Shah ◽  
Dan Eichberg ◽  
...  
Keyword(s):  
Systematic Review ◽  
Central Neurocytoma ◽  
Gross Total Resection ◽  
Treatment Modalities ◽  
Total Resection
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