Potential drug–drug interactions in oncological adult inpatients at a Spanish hospital: epidemiology and risk factors

Objective: This research was instigated to determine and assess the prevalence, severity, type, and the total number of potential drug interactions in the neurology department of two hospitals in India. Methods: The data were collected from the prescriptions and by patient history interview on a daily basis. The drug-drug interactions (DDIs) were identified using Micromedex® database-2.7 and drugs.com. Results: The drug interactions were influenced by a plethora of risk factors: Gender, age, comorbidities, length of hospital stay, and the neurological condition. The study was comprised 320 patients, among 196 patients were identified with potential DDIs (PDDIs), and a total of 450 PDDIs were observed. The prevalence of PDDIs according to the severity was major (42.6%), moderate (45.11%), and minor (12.22%). Conclusion: To lessen PDDIs, the range of medications for the patients must be properly managed, and it is encouraged to remove all medicines without therapeutic advantage, intention, and an indication.

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Prevalence of potential drug-drug interactions in breast cancer patients and determination of their risk factors

Journal of Oncology Pharmacy Practice ◽

10.1177/1078155220963212 ◽

2020 ◽

pp. 107815522096321

Author(s):

Rashida Bibi ◽

Saira Azhar ◽

Ayesha Iqbal ◽

Hajera Jabeen ◽

Umm-e Kalsoom ◽

...

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Drug Interactions ◽

Cancer Patients ◽

Health Care Professionals ◽

Potential Drug ◽

Breast Cancer Patients ◽

Medication Regimen ◽

Cancer Data ◽

Chemotherapy Drugs

Breast cancer patients use numerous medications, which include cytotoxic chemotherapy drugs, hormonal agents and supportive medication, so they are more vulnerable to potential adverse drug interactions. This study aimed to evaluate frequency, severity, clinical importance and risk factors responsible for the Drug-drug interactions (DDIs) in a cohort of patients suffering from breast cancer. Data was obtained from 150 patients in the oncology ward (both inpatient and outpatient) with a confirmed diagnosis of breast cancer and currently receiving standard breast cancer-directed treatment. The data was recorded into a pre-designed form specifically made for this study through individual patient interviews and by reviewing the detailed medical chart records of the patients. DDIs were identified by using drug interaction software such as Medscape mobile application and Micromedex version 2. The results of this study showed that all patients were female. The mean numbers of drugs that patients used were 7. Potential drug interactions were identified in 92% of the patients. When drug groups were overviewed, 32% of interactions were between anti neoplastic drugs, 62.9% interactions were between the anti neoplastic agent and supportive care drugs and 5% of them were between anti-cancer drugs and drugs used to treat comorbidities. Major DDIs were found in 62.2% of patients, 25.3% of DDIs were moderate and 12.4% were minor. The number of drugs, comorbid diseases, and selection of chemo protocols were the risk factors for drug interactions. Most of the DDIs found in breast cancer therapy may have adverse consequences on patient health and therapeutic outcomes. Therefore, health care professionals should review the medication regimen of patients with breast cancer before starting any chemotherapy treatment.

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Risk factors for potential drug-drug interactions in a general neurology ward

Vojnosanitetski pregled ◽

10.2298/vsp190401105k ◽

2019 ◽

pp. 105-105

Author(s):

Marina Kostic ◽

Radica Zivkovic-Zaric ◽

Slobodan Jankovic

Keyword(s):

Risk Factors ◽

Drug Interactions ◽

Potential Drug ◽

General Neurology

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Potential drug-drug interactions among elderly in-patients with cardiac illness at a tertiary care centre

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20200724 ◽

2020 ◽

Vol 9 (3) ◽

pp. 470

Author(s):

Akanksha Mathur ◽

Nidhi Jain ◽

Achal Sharma ◽

Prashant C. Shah

Keyword(s):

Risk Factors ◽

Drug Interactions ◽

Hospital Stay ◽

Pearson Correlation ◽

Tertiary Care ◽

Length Of Hospital Stay ◽

Hospitalized Patients ◽

Close Monitoring ◽

Potential Drug ◽

Cardiac Illness

Background: Drug interactions are major cause of concern in hospitalized patients with cardiac illness especially in elderly population. Therefore, the study was conducted to determine the prevalence and pattern of potential drug-drug interactions (pDDI) and risk factors, if any.Methods: It was a prospective observational study involving 75 elderly in-patients with cardiac diseases. IHEC approval was taken before commencement of study and written informed consent was taken from all the study participants. Data was collected using structured data collection tool. pDDI were analyzed using MEDSCAPE databse. Data was analyzed using SPSS 20.0 in terms of descriptive statistics. Pearson correlation coefficient was used to find the association between the risk factors and potential DDIs. P value of ≤0.05 was considered statistically significant.Results: The prevalence of pDDI was found to be 100%. Total 593 pDDI and 33 interacting drug pairs were observed in the study. The common drug interacting pairs were aspirin and furosemide 140 (23.61%), followed by aspirin+ enalapril 98 (16.53%) and heparin and clopidogrel 56 (9.44%). Majority of pDDI 480 (81%) were found to be of moderate severity. A significant association was documented between length of hospital stay (p=0.041) and occurrence of pDDI. A statistically significant correlation (r =0.621; p<0.01) was noted between number of drugs prescribed and total number of pDDIs.Conclusions: A high prevalence of pDDI was observed. The prevalence rate is directly related to number of drugs prescribed and length of hospital stay. Therefore, close monitoring of hospitalized patients is recommended.

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Prevalence of Potential Drug–Drug Interaction Risk among Chronic Kidney Disease Patients in a Spanish Hospital

Pharmaceutics ◽

10.3390/pharmaceutics12080713 ◽

2020 ◽

Vol 12 (8) ◽

pp. 713

Author(s):

Gracia Santos-Díaz ◽

Ana María Pérez-Pico ◽

Miguel Ángel Suárez-Santisteban ◽

Vanesa García-Bernalt ◽

Raquel Mayordomo ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Drug Interactions ◽

Cross Sectional Study ◽

Potential Drug ◽

Cross Sectional ◽

Major Health Problem ◽

Major Health ◽

Spanish Hospital

Chronic kidney disease (CKD) is a major health problem worldwide and, in Spain, it is present in 15.1% of individuals. CKD is frequently associated with some comorbidities and patients need to be prescribed multiple medications. Polypharmacy increases the risk of adverse drug reactions (ADRs). There are no published studies evaluating the prevalence of potential drug–drug interactions (pDDIs) among CKD patients in any European country. This study was aimed to determine the prevalence, pattern, and factors associated with pDDIs among CKD patients using a drug interactions program. An observational cross-sectional study was carried out at Plasencia Hospital, located in Spain. Data were collected among patients with CKD diagnoses and pDDIs were assessed by the Lexicomp® Drug Interactions platform. Data were obtained from 112 CKD patients. A total number of 957 prescribed medications were acknowledged, and 928 pDDIs were identified in 91% of patients. Age and concomitant drugs were significantly associated with the number of pDDIs (p < 0.05). According to the results, the use of programs for the determination of pDDIs (such as Lexicomp®) is recommended in the clinical practice of CKD patients in order to avoid serious adverse effects, as is paying attention to contraindicated drug combinations.

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Potential drug-drug interactions in hospitalized pediatric patients with respiratory disorders: a retrospective review of clinically important interactions

Drug Metabolism and Personalized Therapy ◽

10.1515/dmpt-2019-0012 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Maryam Hassanzad ◽

Sabereh Tashayoie Nejad ◽

Amir Ali Mahboobipour ◽

Farzaneh Salem ◽

Shadi Baniasadi

Keyword(s):

Risk Factors ◽

Drug Interactions ◽

Pediatric Patients ◽

Pediatric Intensive Care ◽

Respiratory Disorder ◽

Potential Drug ◽

Respiratory Disorders ◽

Drug Classes ◽

Increased Risk ◽

Clinically Significant

Abstract Background Hospitalized pediatric patients are at an increased risk of experiencing potential drug-drug interactions (pDDIs) due to polypharmacy and the unlicensed and off-label administration of drugs. The aim of this study is to characterize clinically significant pDDIs in pediatric patients hospitalized in a tertiary respiratory center. Methods A retrospective analysis of medications prescribed to pediatric patients admitted to the pediatric ward (PW) and pediatric intensive care unit (PICU) of a respiratory referral center was carried out over a six-month period. The pDDIs were identified using the Lexi-Interact database and considered as clinically relevant according to the severity rating as defined in the database. Frequency, drug classes, mechanisms, clinical managements, and risk factors were recorded for these potential interactions. Results Eight hundred and forty-five pDDIs were identified from the analysis of 176 prescriptions. Of the total pDDIs, 10.2% in PW and 14.6% in PICU were classified as clinically significant. Anti-infective agents and central nervous system drugs were the main drug classes involved in clinically significant pDDIs as object and/or precipitant drugs. A higher number of medications [odds ratio (OR): 4.8; 95% confidence interval (CI): 2.0–11.4; p < 0.001] and the existence of a nonrespiratory disease, which led to a respiratory disorder (OR: 3.8; 95% CI: 1.40–10.4; p < 0.05), were the main risk factors associated with an increased incidence of pDDIs. Conclusions A high and similar risk of pDDIs exists in pediatric patients with respiratory disorders hospitalized in PW and PICU. The patients prescribed a higher number of medications and presenting respiratory symptoms induced by a nonrespiratory disease require extra care and monitoring. Pediatricians should be educated about clinically significant DDIs for highly prescribed medications in their settings in order to take preventive measures and safeguard patient safety.

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Risk Factors for the Occurrence of Potential Drug-drug Interactions in Surgical Patients

Serbian Journal of Experimental and Clinical Research ◽

10.2478/sjecr-2019-0032 ◽

2019 ◽

Vol 0 (0) ◽

Author(s):

Miloš N. Milosavljevic ◽

Aleksandar G. Kočovic ◽

Slobodan M. Jankovic ◽

Dragče M. Radovanovic ◽

Slobodan S. Milisavljevic ◽

...

Keyword(s):

Risk Factors ◽

Heart Failure ◽

Drug Interactions ◽

Cohort Analysis ◽

Personal Digital Assistant ◽

Antiarrhythmic Therapy ◽

Surgical Patients ◽

Potential Drug ◽

Clinical Center ◽

Clinically Significant

Abstract Background: Drug-drug interactions are defined as modifications of the drug action that result from the simultaneous administration of another individual drug or several drugs. Nowadays, potential drug-drug interactions (DDIs) are most frequently detected and analyzed using personal digital assistant software programs (online interaction checker tools). Objective: To determine the risk factors for the emergence of all drug-drug interactions in surgical patients with particular emphasis on clinically significant interactions. Patients and methods: This was a retrospective cohort analysis of patients treated at the Surgical Clinic of the Clinical Center Kragujevac. Three interaction checkers were used to reveal drug-drug interactions: Medscape, Epocrates and Micromedex. Results: The study included total of 200 patients, aged 58.54±17.08 years. Average number of drug-drug interactions per patient was between 10.50±9.10 (Micromedex) and 18.75±17.14 (Epocrates). Number of prescribed drugs, antidepressive therapy, antiarrhythmic therapy, number of pharmacological/therapeutic subgroups (2nd level of ATC classification) prescribed, delirium or dementia, diabetes, heart failure, and number of physicians who prescribed drugs to single patient were identified as risk factors for drug-drug interactions while length of hospitalization in days and age of patient in years emerged as protective factors. Conclusion: Drug-drug interactions are relatively common in surgical patients and predisposed by factors such as number of prescribed drugs or drug group per patient, number of physicians who prescribed drugs, antidepressive therapy, antiarrhythmic therapy, presence of delirium or dementia, diabetes and heart failure. On the other hand, prolonged hospitalization and higher age are factors that reduce the risk of interactions in surgical patients.

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