Prognostic implications of sarcomatoid and rhabdoid differentiation in patients with grade 4 renal cell carcinoma

2016 ◽  
Vol 48 (8) ◽  
pp. 1253-1260 ◽  
Author(s):  
Onder Kara ◽  
Matthew J. Maurice ◽  
Homayoun Zargar ◽  
Ercan Malkoc ◽  
Oktay Akca ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Prognostic Implications ◽  
Rhabdoid Differentiation

scholarly journals Renal cell carcinoma with rhabdoid differentiation: A novel entity with immunohistochemical study

2016 ◽  
Vol 59 (4) ◽  
pp. 565
Author(s):  
AAil Divya ◽  
GSinai Kandheparkar Siddhi ◽  
RJoshi Avinash ◽  
DBhayekar Pallavi
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Immunohistochemical Study ◽  
Rhabdoid Differentiation

scholarly journals Alteration of CYP4A11 expression in renal cell carcinoma: diagnostic and prognostic implications

2020 ◽  
Vol 11 (6) ◽  
pp. 1478-1485 ◽  
Author(s):  
Sup Kim ◽  
Jin Man Kim ◽  
Hyo Jin Lee ◽  
Jae Sung Lim ◽  
In-Ock Seong ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Prognostic Implications

scholarly journals A Case of Heterotopic Ossification in Papillary Renal Cell Carcinoma Type 2

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Facundo Davaro ◽  
Elizabeth Davaro ◽  
Amna Qureshi ◽  
Lindsay Lombardo
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Heterotopic Ossification ◽  
Renal Cell ◽  
Specific Immunotherapy ◽  
Papillary Renal Cell Carcinoma ◽  
Young Female ◽  
Prognostic Implications ◽  
Papillary Type

Renal cell carcinoma (RCC) is associated with a variety of different histopathologic subtypes in which each subtype may be further subclassified. These entities carry with them unique prognoses and necessitate treatment with specific immunotherapy agents should advanced disease be uncovered. Meanwhile, aberrant physiologic processes may lead to unique histologic findings within these subtypes, further complicating management and prognostication. Heterotopic ossification within RCC is one of these rare occurrences and was once thought to have favorable prognostic implications. We report a case of a young female with papillary type 2 RCC with heterotopic ossification.

Impact of rhabdoid differentiation on postoperative outcome for patients with N0M0 renal cell carcinoma

2019 ◽  
Vol 37 (10) ◽  
pp. 711-720
Author(s):  
Hakushi Kim ◽  
Chie Inomoto ◽  
Takato Uchida ◽  
Hiroshi Kajiwara ◽  
Tomoyoshi Komiyama ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Postoperative Outcome ◽  
Rhabdoid Differentiation

Genetic alterations in renal cell carcinoma with rhabdoid differentiation

2015 ◽  
Vol 46 (1) ◽  
pp. 9-16 ◽  
Author(s):  
Carmen M. Perrino ◽  
Vishwanathan Hucthagowder ◽  
Michael Evenson ◽  
Shashikant Kulkarni ◽  
Peter A. Humphrey
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Genetic Alterations ◽  
Rhabdoid Differentiation

The impact of rhabdoid differentiation on prognosis in patients with grade 4 renal cell carcinoma.

2015 ◽  
Vol 33 (7_suppl) ◽  
pp. 494-494
Author(s):  
Ben Yiming Zhang ◽  
John C. Cheville ◽  
Robert Houston Thompson ◽  
Stephen A. Boorjian ◽  
Christine M. Lohse ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Risk Of Death ◽  
Pathologic Features ◽  
Increased Risk ◽  
Grade 3 ◽  
Rhabdoid Differentiation ◽  
The Impact ◽  
Sarcomatoid Differentiation

494 Background: Renal cell carcinoma (RCC) with rhabdoid differentiation is thought to portend a poor prognosis, similar to RCC with sarcomatoid differentiation. Both rhabdoid and sarcomatoid differentiation are classified as grade 4 RCC based on the most recent International Society of Urological Pathology (ISUP) grading system. We sought to determine the prognostic value of rhabdoid differentiation in comparison to RCC with sarcomatoid differentiation, grade 4 RCC without rhabdoid or sarcomatoid differentiation, and grade 3 RCC. Methods: Using the Mayo Clinic Nephrectomy Registry, we identified 406 patients with ISUP grade 4 RCC and 1,758 patients with grade 3 RCC. A urologic pathologist reviewed all specimens to determine the presence of both rhabdoid and sarcomatoid differentiation. Associations of clinical and pathologic features with death from RCC were evaluated using Cox models. Results: Among the 406 grade 4 RCC tumors, 111 (27%) had rhabdoid differentiation and 189 (47%) had sarcomatoid differentiation, although only 28 (7%) demonstrated both rhabdoid and sarcomatoid differentiation. In multivariable analysis of grade 4 RCC tumors, the presence of rhabdoid differentiation was not associated with death from RCC (HR 0.95, p=0.75); in contrast, sarcomatoid differentiation was significantly associated with death from RCC (HR 1.63, p<0.001). Patients with RCC with rhabdoid differentiation were significantly more likely to die of RCC than patients with grade 3 RCC (HR 2.45, p<0.001) and grade 3 RCC with necrosis (HR 1.62; p<0.001). Conclusions: This study confirms that RCC with rhabdoid differentiation is appropriately classified as grade 4. However, unlike sarcomatoid differentiation, the presence of rhabdoid differentiation in grade 4 RCC is not associated with an increased risk of death from RCC. Therefore, rhabdoid and sarcomatoid differentiation should not be grouped together when assessing risk in a patient with grade 4 RCC.

Renal Oncocytoma: Report of Two Cases

1983 ◽  
Vol 69 (3) ◽  
pp. 271-277 ◽  
Author(s):  
Anna Parenti ◽  
Paolo Dalla Palma ◽  
Mario Piazza
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Final Diagnosis ◽  
Histologic Examination ◽  
Renal Oncocytoma ◽  
Radiologic Findings ◽  
Large Size ◽  
Benign Nature ◽  
Prognostic Implications

The clinico-radiologic, gross, microscopic and ultrastructural findings in 2 cases of renal oncocytoma are reported. The diagnosis of renal oncocytoma has important clinical and prognostic implications, since the neoplasia is usually benign despite its often large size. The differential diagnosis with other renal neoplasms, in particular renal cell carcinoma, is discussed. The problem of the pre-operatory diagnosis of renal oncocytoma is explored on the basis of clinico-radiologic findings and/or histologic examination of pre- or intraoperatory biopsy. In view of the tumor's benign nature, this diagnosis implies tumorectomy, but its close resemblance to renal cell carcinoma at present counsels nephrectomy. A final diagnosis of oncocytoma may be formulated only after histologic examination of several specimens and ultrastructural confirmation.

Prognostic Implications of the Immunohistochemical Expression of Human Kallikreins 5, 6, 10 and 11 in Renal Cell Carcinoma

Tumor Biology ◽  
2006 ◽  
Vol 27 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Constantina D. Petraki ◽  
Alkiviadis K. Gregorakis ◽  
Michael M. Vaslamatzis ◽  
Panagiotis A. Papanastasiou ◽  
George M. Yousef ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Immunohistochemical Expression ◽  
Prognostic Implications
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