High-intensity interval training combined with resistance training improved apnea-hypopnea index but did not modify oxygen desaturation index and oxygen saturation nadir in obese children with obstructive sleep apnea

2019 ◽  
Vol 24 (2) ◽  
pp. 571-580
Author(s):  
Khomkrip Longlalerng ◽  
Nuntigar Sonsuwan ◽  
Sureeporn Uthaikhup ◽  
Suchart Kietwatanachareon ◽  
Warunee Kamsaiyai ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Resistance Training ◽  
Interval Training ◽  
Apnea Hypopnea Index ◽  
High Intensity Interval Training ◽  
Obese Children ◽  
Oxygen Desaturation Index ◽  
Obstructive Sleep ◽  
High Intensity Interval

scholarly journals Nocturnal Hypoxemia Impacts Right Ventricle Diastolic Function in Obstructive Sleep Apnea: A Retrospective Observational Study

2020 ◽  
Vol 9 (1) ◽  
pp. 162 ◽  
Author(s):  
Carla Scotti ◽  
Roberto Porta ◽  
Adriana Olivares ◽  
Laura Comini ◽  
Angelo Cinelli ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Right Ventricle ◽  
Apnea Hypopnea Index ◽  
Oxyhemoglobin Saturation ◽  
Oxygen Desaturation Index ◽  
Obstructive Sleep ◽  
Echocardiographic Examination ◽  
Echocardiographic Parameters ◽  
Deceleration Time

Obstructive sleep apnea (OSA), although a growing healthcare problem and documented risk factor for cardiovascular diseases, is still under-diagnosed in cardiac patients. To investigate the correlation between OSA and echocardiographic parameters of right ventricle diastolic (RVD) dysfunction, in particular trans-tricuspid E-wave deceleration time (EDT), we retrospectively analyzed data of 103 pure (comorbidity-free) OSA patients with comprehensive echocardiographic examination (ETT). Apnea/hypopnea index (AHI), oxygen desaturation index (ODI), mean nighttime oxyhemoglobin saturation (SpO2), time elapsed with SpO2 < 90% (T90) and mean peak desaturation of nocturnal events (Mdes, graded as mild, medium or severe) were compared with echocardiographic parameters. We found RVD dysfunction present in 58.3% of patients. Altered EDT correlated significantly with mean SpO2, T90, and Mdes (p < 0.01, all). Nocturnal desaturators had a significantly worse EDT than non-desaturators (p = 0.027) and a higher risk of prolonged EDT (odds ratio, OR = 2.86). EDT differed significantly according to Mdes severity (p = 0.005) with a higher risk of prolonged EDT in medium/severe vs. mild Mdes (OR = 3.44). EDT detected the presence of RVD dysfunction in 58.3% of our pure OSA patients. It correlated poorly with AHI severity but strongly with nocturnal desaturation severity, independently of age. This ETT marker may be useful for deciding appropriate diagnostic and therapeutic strategies.

Agreement Between Oxygen Desaturation Index and Apnea-Hypopnea Index in Adults With Suspected Obstructive Sleep Apnea at an Altitude of 2240 m

2007 ◽  
Vol 43 (12) ◽  
pp. 649-654 ◽  
Author(s):  
Luis Torre-Bouscoulet ◽  
Armando Castorena-Maldonado ◽  
Rocío Baños-Flores ◽  
Juan Carlos Vázquez-García ◽  
María Sonia Meza-Vargas ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Oxygen Desaturation ◽  
Apnea Hypopnea Index ◽  
Desaturation Index ◽  
Oxygen Desaturation Index ◽  
Obstructive Sleep

scholarly journals Advanced age and apnea-hypopnea index predict subclinical atherosclerosis in patients with obstructive sleep apnea syndrome

2013 ◽  
Vol 8 ◽  
Author(s):  
Bilal Arik ◽  
Mehmet Fatih Inci ◽  
Cesur Gumus ◽  
Kenan Varol ◽  
Meltem Refiker Ege ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Coronary Artery ◽  
Sleep Apnea ◽  
Subclinical Atherosclerosis ◽  
Sleep Apnea Syndrome ◽  
Calcium Score ◽  
Apnea Hypopnea Index ◽  
Oxygen Desaturation Index ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Background: Both obstructive sleep apnea syndrome (OSAS) and coronary artery calcification (CAC) are considered to be related with the presence of coronary artery disease (CAD). In this study we evaluate the association between OSAS and presence of subclinical atherosclerosis assessed by tomographic coronary calcium score in patients who had OSAS but no history of known CAD. Methods: Seventy-three patients who were asymptomatic for CAD and had suspected OSAS were referred to overnight attended polysomnography. Patients were classified into 4 groups according to the Apnea-Hypopnea Index (AHI). All patients underwent computed tomographic examination for tomographic coronary calcification scoring. Physical examination, sleep study recordings, complete blood count and serum biochemistry were obtained from all patients. Results: In the whole group, AHI levels were weakly correlated with coronary calcium score (r = 0.342, p = 0.003) and body mass index (r = 0.337, p = 0.004), moderately correlated with basal oxygen saturation (r = −0.734, p < 0.001), and strongly correlated with oxygen desaturation index (r = 0.844, p < 0.001). In an univariate analysis, age, AHI, basal oxygen saturation, and oxygen desaturation index were associated with CAC in patients with OSAS. In a multiple logistic regression model, age (OR 1.108,%95 CI 1.031-1.191, p = 0.005) and AHI (OR 1.036,% 95 CI 1.003-1.070, p = 0.033) were only independent predictors of CAC in patients with OSAS with a sensitivity of 88.9% and 77.8% and a specificity of 54.3% and 56.5% respectively. Conclusions: Our findings suggest that in patients with moderate or severe OSAS and advanced age, physicians should be alert for the presence of subclinical atherosclerosis.

Outcome of Adenotonsillectomy for Obstructive Sleep Apnea in Obese and Normal-Weight Children

2007 ◽  
Vol 137 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Ron B. Mitchell ◽  
James Kelly
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Controlled Trial ◽  
Normal Weight ◽  
Apnea Hypopnea Index ◽  
Dramatic Improvement ◽  
Obese Children ◽  
Respiratory Parameters ◽  
Obstructive Sleep ◽  
Study Participants

OBJECTIVES: 1) To evaluate the relative severity of obstructive sleep apnea (OSA) in obese and normal-weight children; 2) to compare changes in respiratory parameters after adenotonsillectomy in obese and normal-weight children. STUDY DESIGN AND SETTING: Prospective controlled trial that included children aged 3 to 18 years. All study participants underwent pre- and postoperative polysomnography. RESULTS: The study population included 33 obese children and 39 normal-weight controls. Preoperatively, the median obstructive apnea-hypopnea index (AHI) was 23.4 (range 3.7-135.1) for obese and 17.1 (range 3.9-36.5) for controls ( P < 0.001). Postoperatively, the AHI was 3.1 (range 0-33.1) for obese and 1.9 (range 0.1-7.0) for controls ( P < 0.01). Twenty-five obese children (76%) and 11 controls (28%) had persistent OSA. CONCLUSION AND SIGNIFICANCE: AHI scores are higher in obese than in normal-weight children with OSA. Both groups show a dramatic improvement in AHI after adenotonsillectomy, but persistent OSA is more common in obese children.

scholarly journals Clinical Usefulness of New R-R Interval Analysis Using the Wearable Heart Rate Sensor WHS-1 to Identify Obstructive Sleep Apnea: OSA and RRI Analysis Using a Wearable Heartbeat Sensor

2020 ◽  
Vol 9 (10) ◽  
pp. 3359
Author(s):  
Takuo Arikawa ◽  
Toshiaki Nakajima ◽  
Hiroko Yazawa ◽  
Hiroyuki Kaneda ◽  
Akiko Haruyama ◽  
...  
Keyword(s):  
Heart Rate ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Saturation Index ◽  
Cost Effective ◽  
Sleep Time ◽  
Apnea Hypopnea Index ◽  
Oxygen Desaturation Index ◽  
Obstructive Sleep ◽  
Rate Sensor

Obstructive sleep apnea (OSA) is highly associated with cardiovascular diseases, but most patients remain undiagnosed. Cyclic variation of heart rate (CVHR) occurs during the night, and R-R interval (RRI) analysis using a Holter electrocardiogram has been reported to be useful in screening for OSA. We investigated the usefulness of RRI analysis to identify OSA using the wearable heart rate sensor WHS-1 and newly developed algorithm. WHS-1 and polysomnography simultaneously applied to 30 cases of OSA. By using the RRI averages calculated for each time series, tachycardia with CVHR was identified. The ratio of integrated RRIs determined by integrated RRIs during CVHR and over all sleep time were calculated by our newly developed method. The patient was diagnosed as OSA according to the predetermined criteria. It correlated with the apnea hypopnea index and 3% oxygen desaturation index. In the multivariate analysis, it was extracted as a factor defining the apnea hypopnea index (r = 0.663, p = 0.003) and 3% oxygen saturation index (r = 0.637, p = 0.008). Twenty-five patients could be identified as OSA. We developed the RRI analysis using the wearable heart rate sensor WHS-1 and a new algorithm, which may become an expeditious and cost-effective screening tool for identifying OSA.

scholarly journals Prediction of obstructive sleep apnea: comparative performance of three screening instruments on the apnea-hypopnea index and the oxygen desaturation index

2020 ◽  
Author(s):  
Christianne C. A. F. M. Veugen ◽  
Emma M. Teunissen ◽  
Leontine A. S. den Otter ◽  
Martijn P. Kos ◽  
Robert J. Stokroos ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Oxygen Desaturation ◽  
Screening Tools ◽  
Apnea Hypopnea Index ◽  
Screening Instruments ◽  
Comparative Performance ◽  
Desaturation Index ◽  
Oxygen Desaturation Index ◽  
Obstructive Sleep

Abstract Purpose To evaluate the performance of the NoSAS (neck, obesity, snoring, age, sex) score, the STOP-Bang (snoring, tiredness, observed apneas, blood pressure, body mass index, age, neck circumference, gender) questionnaire, and the Epworth sleepiness score (ESS) as a screening tool for obstructive sleep apnea (OSA) severity based on the apnea-hypopnea index (AHI) and the oxygen desaturation index (ODI). Methods Data from 235 patients who were monitored by ambulant polysomnography (PSG) were retrospectively analyzed. OSA severity was classified based on the AHI; similar classification categories were made based on the ODI. Discrimination was assessed by the area under the curve (AUC), while predictive parameters were calculated by four-grid contingency tables. Results The NoSAS score and the STOP-Bang questionnaire were both equally adequate screening tools for the AHI and the ODI with AUC ranging from 0.695 to 0.767 and 0.684 to 0.767, respectively. Both questionnaires perform better when used as a continuous variable. The ESS did not show adequate discrimination for screening for OSA (AUC ranging from 0.450 to 0.525). Male gender, age, and BMI proved to be the strongest individual predictors in this cohort. Conclusion This is the first study to evaluate the predictive performance of three different screening instruments with respect to both the AHI and the ODI. This is important, due to increasing evidence that the ODI may have a higher reproducibility in the clinical setting. The NoSAS score and the STOP-Bang questionnaire proved to be equally adequate to predict OSA severity based on both the AHI and the ODI.

Apnea Hypopnea Index, Oxygen Desaturation Index, and QTC Interval in Obstructive Sleep Apnea

CHEST Journal ◽  
2015 ◽  
Vol 148 (4) ◽  
pp. 1056A
Author(s):  
Stefan Dumitrache-Rujinski ◽  
Ionela Erhan ◽  
Alexandru Cocieru ◽  
Ionela Butuc-Andreescu ◽  
Alexandru Muntean ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Oxygen Desaturation ◽  
Apnea Hypopnea Index ◽  
Qtc Interval ◽  
Desaturation Index ◽  
Oxygen Desaturation Index ◽  
Obstructive Sleep

Tonsillectomy for Obstructive Sleep Apnea in Obese Children

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P69-P70
Author(s):  
Dary J Costa ◽  
Ron B Mitchell
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Oxygen Saturation ◽  
Weighted Mean Difference ◽  
Mean Difference ◽  
Apnea Hypopnea Index ◽  
Obese Children ◽  
Weighted Mean ◽  
Obstructive Sleep ◽  
The Mean

Objective To determine the effectiveness of adenotonsillectomy (T&A) for treating obstructive sleep apnea (OSA) in obese children. Methods Meta-analysis of studies that reported sleep parameters in obese children with OSA before and after T&A. Data was analyzed using the random effects model. Statistical significance was P less than 0.05. Results Data from four studies that included 110 children were analyzed. Mean sample size was 27.5 (range: 18 - 33). Mean body mass index (BMI) z-score was 2.81. The mean pre-and postoperative apnea-hypopnea index (AHI) was 29.0 (range 22.2 - 34.3) and 9.9 (range 6.0 - 12.2) respectively. The weighted mean difference between pre- and postoperative AHI was a significant reduction of 18.3 events per hour (95% CI 11.2–25.5). The mean pre- and postoperative oxygen saturation nadir was 78.9% (range 73.9 -81.1%) and 85.7% (83.6 -89.9%) respectively. The weighted mean difference was a significant increase in the oxygen saturation nadir of 6.3% (95% CI 3.9 to 8.7). Approximately 43% of children had a postoperative AHI less than 5, 21% of children had a postoperative AHI less than 2, and 11% of children had a postoperative AHI less than 1. Conclusions T&A improves but does not resolve OSA in the majority of obese children. Up to 89% of obese children have persistent OSA after T&A. The efficacy and role of additional therapeutic options requires more study. The high incidence of obesity in children makes this a public health priority.

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