Renal protective effects of grape seed extract treatment against Eltroxin-induced hyperthyroidism, kidney damage, and oxidative stress in male mice

2020 ◽  
Vol 27 (15) ◽  
pp. 17963-17971
Author(s):  
Tarfa Albrahim ◽  
Alwin Robert
Keyword(s):  
Oxidative Stress ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Kidney Damage ◽  
Protective Effects ◽  
Male Mice ◽  
And Oxidative Stress

Preventive effect of grape seed extract against high-fructose diet-induced insulin resistance and oxidative stress in rats

2010 ◽  
Vol 48 (7) ◽  
pp. 1853-1857 ◽  
Author(s):  
Wannaporn Suwannaphet ◽  
Aramsri Meeprom ◽  
Sirintorn Yibchok-Anun ◽  
Sirichai Adisakwattana
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Preventive Effect ◽  
High Fructose Diet ◽  
High Fructose ◽  
And Oxidative Stress

scholarly journals Pre-Treatment with Grape Seed Extract Reduces Inflammatory Response and Oxidative Stress Induced by Helicobacter pylori Infection in Human Gastric Epithelial Cells

Antioxidants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 943
Author(s):  
Jose Manuel Silvan ◽  
Alba Gutierrez-Docio ◽  
Esperanza Guerrero-Hurtado ◽  
Lucia Domingo-Serrano ◽  
Ana Blanco-Suarez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Helicobacter Pylori ◽  
Epithelial Cells ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Gastric Epithelial Cells ◽  
Pre Treatment ◽  
H Pylori ◽  
And Oxidative Stress

Helicobacter pylori (H. pylori) is a pathogenic bacteria identified as a potential risk factor for gastritis, gastric ulcers and gastric cancer. During the stomach colonization, H. pylori triggers a strong inflammatory response and subsequent oxidative stress, which are associated with tissue damage. For this reason, it is of particular interest to develop alternative natural tools that enable modulation of the associated damaging immune response. With this purpose, we obtained grape seed extract (GSE) from sweet (not fermented) food grade seeds. The aim of our study was to investigate the effect of GSE and its two enriched procyanidins fractions (OPC and PPC) on the inflammatory process and oxidative stress produced by different H. pylori strains in human gastric epithelial cells (AGS). Anti-inflammatory activity was evaluated by measuring the level of interleukin-8 (IL-8) secretion. IL-8 production was significantly reduced in H. pylori-infected human gastric epithelial cells pre-treated with GSE or its enriched fractions when compared with non-pre-treated infected cells (from 21.6% to 87.8%). Pre-treatment with GSE or its fractions significantly decreased intracellular reactive oxygen species (ROS) production in AGS cells after infection, depending on the H. pylori strain. Our results also showed that GSE and its fractions demonstrate antibacterial activity against all strains of H. pylori used in the study. This work demonstrates the effectiveness of GSE enriched in procyanidins against the main events associated with H. pylori infection.

scholarly journals Noise Exposure Decreases the Number of Spermatozoa in Male Mice (Mus musculus L.) Even With Grape Seed Extract (Vitis vinifera L.) Administration

2020 ◽  
Vol 5 (2) ◽  
pp. 70-75
Author(s):  
Ghestiara Siregar
Keyword(s):  
Treatment Group ◽  
Mus Musculus ◽  
Noise Exposure ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Control Group ◽  
Vitis Vinifera L ◽  
Not Given ◽  
Male Mice

  Excessive continuous noises exposure changes the male hormone system which leads to formation of oxidative stress and results in disrupt of semen quality. This condition can be reduced by the use of antioxidants. Grape seed is one of the antioxidants that contains phenol components that have Resveratrol compounds. This research aimed to observe the effect of noise exposure on the number of spermatozoa of male mice given grape seed extract. The method of the research was a post-test only control group design with research subjects of 30 male Mus musculus L. (Swiss Webster) mice divided into 5 groups: group A (treatment control) was not given noise exposure and grape seed extract, group B (negative control) was not given noise exposure and was given grape seed extract, groups C, D, E (treatment group) were given noise exposure with sequential intensities of 65 dB, 85 dB, 105 dB. The treatment was given for 33 days. The results showed that noise exposure with different intensities of 65 dB, 85 dB, 105 dB reduced the spermatozoa count of male Swiss Webster mice even with the administration of grape seed extract. One Way Anova test was used to analyze the data with p-value of 0.001. Conclusion: There were differences in spermatozoa count between the control group and the treatment group. Provision of noise exposure with a value above the threshold limit reduces the number of male Swiss Webster mice spermatozoa given with grape seed extract. Keywords: Number of Spermatozoa, Grape Seed Extract, Noise exposure  

scholarly journals Neuroprotection of Grape Seed Extract and Pyridoxine against Triton-Induced Neurotoxicity

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Heba M. Abdou ◽  
Mayssaa M. Wahby
Keyword(s):  
Vitamin B6 ◽  
Hematological Parameters ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Cerebral Injury ◽  
Pcr Analysis ◽  
Albino Rats ◽  
Inos Mrna ◽  
Protective Effects

Triton WR-1339 administration causes neurotoxicity. Natural products and herbal extracts can attenuate cerebral injury. In the present study, we investigated the neuroprotective role of grape seed extract and/or vitamin B6 against triton-induced neurotoxicity. Thirty-five adult male albino rats of the Sprague-Dawley strain, weighing 140–145 g, were divided into five groups: control, triton, grape seed extract + triton, grape seed extract + triton + vitamin B6, and vitamin B6 + triton. The hematological and biochemical analyses were carried out. Alteration in iNOS mRNA gene expression was determined using reverse-transcriptase PCR analysis. In addition, qualitative DNA fragmentation was examined using agarose gel electrophoresis. Triton-treatment caused significant disturbances in the hematological parameters, the neurological functions, and the antioxidant profile. Also, triton significantly increased the iNOS mRNA expression and DNA damage. Our results showed that grape seed extract and/or vitamin B6 could attenuate all the examined parameters. These natural substances could exhibit protective effects against triton-induced neurological damage because of their antioxidative and antiapoptotic capacities.

scholarly journals Alleviation of haloperidol induced oxidative stress in rats: Effects of sucrose vs grape seed extract

2015 ◽  
Vol 53 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Sally A. El-Awdan ◽  
Gehad A. Abdel Jaleel ◽  
Dalia O. Saleh
Keyword(s):  
Oxidative Stress ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract

scholarly journals Role of oxidative stress in cytotoxicity of grape seed extract in human bladder cancer cells

2013 ◽  
Vol 61 ◽  
pp. 187-195 ◽  
Author(s):  
Komal Raina ◽  
Alpna Tyagi ◽  
Dileep Kumar ◽  
Rajesh Agarwal ◽  
Chapla Agarwal
Keyword(s):  
Oxidative Stress ◽  
Bladder Cancer ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Bladder Cancer Cells ◽  
Human Bladder Cancer Cells
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