scholarly journals Correction to: Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation

2021 ◽  
Author(s):  
Rui Tang ◽  
Atsushi Kimishima ◽  
Ryosuke Ishida ◽  
Andi Setiawan ◽  
Masayoshi Arai
Keyword(s):  
Cancer Cells ◽  
Glucose Starvation ◽  
Selective Cytotoxicity ◽  
Trichoderma Lixii

A correction to this paper has been published: https://doi.org/10.1007/s11418-021-01499-w

Glucose starvation greatly enhances antiproliferative and antiestrogenic potency of oligomycin A in MCF-7 breast cancer cells

Biochimie ◽  
2021 ◽  
Vol 186 ◽  
pp. 51-58
Author(s):  
Alexander M. Scherbakov ◽  
Danila V. Sorokin ◽  
Olga A. Omelchuk ◽  
Andrey E. Shchekotikhin ◽  
Mikhail A. Krasil’nikov
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Glucose Starvation ◽  
Oligomycin A ◽  
Mcf 7

scholarly journals Non-essential amino acids attenuate apoptosis of gastric cancer cells induced by glucose starvation

2014 ◽  
Vol 32 (1) ◽  
pp. 332-340 ◽  
Author(s):  
GANG WANG ◽  
LEI DAI ◽  
LAISHENG LUO ◽  
WEN XU ◽  
CHENJING ZHANG ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Amino Acids ◽  
Cancer Cells ◽  
Essential Amino Acids ◽  
Glucose Starvation ◽  
Gastric Cancer Cells

scholarly journals Resistance to glucose starvation as metabolic trait of platinum-resistant human epithelial ovarian cancer cells

Oncotarget ◽  
2016 ◽  
Vol 8 (4) ◽  
pp. 6433-6445 ◽  
Author(s):  
Anna Pastò ◽  
Anna Pagotto ◽  
Giorgia Pilotto ◽  
Angela De Paoli ◽  
Gian Luca De Salvo ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells ◽  
Glucose Starvation ◽  
Metabolic Trait ◽  
Platinum Resistant

scholarly journals β-Ketoiminato Iridium(III) Organometallic Complexes: Selective Cytotoxicity towards Colorectal Cancer Cells HCT116 p53 -/-

2018 ◽  
Vol 25 (2) ◽  
pp. 495-500 ◽  
Author(s):  
Rianne M. Lord ◽  
Markus Zegke ◽  
Imogen R. Henderson ◽  
Christopher M. Pask ◽  
Helena J. Shepherd ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Organometallic Complexes ◽  
Selective Cytotoxicity ◽  
Colorectal Cancer Cells

Combination of culture on collagen gels and glucose starvation for cloning human colon cancer cells

1991 ◽  
Vol 5 (2) ◽  
pp. 117-127 ◽  
Author(s):  
Maxime Lehmann ◽  
Chantal Rabenandrasana ◽  
Jean-Baptiste Rognoni ◽  
Bernard Verrier ◽  
Jacques Marvaldi ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Glucose Starvation ◽  
Colon Cancer Cells ◽  
Collagen Gels ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

scholarly journals Ruthenium-Containing Linear Helicates and Mesocates with Tuneable p53-Selective Cytotoxicity in Colorectal Cancer Cells

2018 ◽  
Vol 57 (31) ◽  
pp. 9799-9804 ◽  
Author(s):  
Simon J. Allison ◽  
David Cooke ◽  
Francesca S. Davidson ◽  
Paul I. P. Elliott ◽  
Robert A. Faulkner ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Selective Cytotoxicity ◽  
Colorectal Cancer Cells

scholarly journals Pentagalloylglucose, isolated from the leaf extract of Anacardium occidentale L., could elicit rapid and selective cytotoxicity in cancer cells

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Bamigboye J. Taiwo ◽  
Temidayo D. Popoola ◽  
Fanie R. van Heerden ◽  
Amos A. Fatokun
Keyword(s):  
Oxidative Stress ◽  
Cancer Cells ◽  
Cell Line ◽  
Cancer Cell ◽  
Leaf Extract ◽  
Anacardium Occidentale ◽  
Selective Cytotoxicity ◽  
Anti Oxidant ◽  
High Concentrations ◽  
Foetal Lung

ABSTRACT Background The leaf of Anacardium occidentale L. has been a component of many herbal recipes in South-Western Nigeria. The work reported herein, therefore, explored the phytochemical composition of this plant and the potential anti-cancer activity of an isolated chemical constituent. Methods Phytochemical methods (including chromatographic analysis) combined with spectroscopic and spectrometric analyses (IR, HRMS and NMR (1D and 2D)) were used to identify chemical constituents. Cytotoxic effects were determined using the MTT viability assay and bright-field imaging. Induction of oxidative stress was determined using the fluorescence-based 2′,7′-dichlorofluorescein diacetate (DCFDA) assay. Results For the first time in the plant, Compound 1 was isolated from the leaf extract and identified as pentagalloylglucose. Compound 1 was significantly cytotoxic against the cancer cell lines HeLa (human cervical adenocarcinoma cell line) and MRC5-SV2 (human foetal lung cancer cell line), with IC50 of 71.45 and 52.24 μg/ml, respectively. The selectivity index (SI) for Compound 1 was 1.61 (IC50 against the normal human foetal lung fibroblast cell line MRC-5 was 84.33μg/ml), demonstrating better cancer cell-selectivity compared to doxorubicin with a SI of 1.28. The cytotoxic activity of Compound 1 in HeLa cells was also rapid, as shown by its concentration- and time-dependent 3 h and 6 h cytotoxicity profiles, an effect not observed with doxorubicin. Generation of reactive oxygen species at high concentrations of pentagalloylglucose to induce oxidative stress in cancer cells was identified as a mechanistic event that led to or resulted from its cytotoxicity. Conclusions We suggest that pentagalloylglucose is selectively cytotoxic to cancer cells, and at high concentrations could exhibit pro-oxidant effects in those cells, as opposed to its general anti-oxidant effects in cells. Also, the presence of Compound 1 (pentagalloylglucose) in the plant and its cancer cell-selective cytotoxicity provide some rationale for the ethno-medicinal use of the plant’s leaf extract for treating diseases associated with excessive cell proliferation. Further studies are required to dissect the molecular mechanisms and players differentially regulating the biphasic anti-oxidant and pro-oxidant effects of pentagalloylglucose in normal and cancer cells.

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