Brain Selective Estrogen Treatment Protects Dopaminergic Neurons and Preserves Behavioral Function in MPTP-induced Mouse Model of Parkinson’s Disease

2020 ◽  
Author(s):  
Nidheesh Thadathil ◽  
Jianfeng Xiao ◽  
Roderick Hori ◽  
Stephen E. Alway ◽  
Mohammad Moshahid Khan
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Dopaminergic Neurons ◽  
Estrogen Treatment ◽  
Behavioral Function

scholarly journals Simvastatin Inhibits the Activation of p21ras and Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson's Disease

2009 ◽  
Vol 29 (43) ◽  
pp. 13543-13556 ◽  
Author(s):  
A. Ghosh ◽  
A. Roy ◽  
J. Matras ◽  
S. Brahmachari ◽  
H. E. Gendelman ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Dopaminergic Neurons

Protection of Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease by a Physically-Modified Saline Containing Charge-Stabilized Nanobubbles

2013 ◽  
Vol 9 (2) ◽  
pp. 218-232 ◽  
Author(s):  
Saurabh Khasnavis ◽  
Avik Roy ◽  
Supurna Ghosh ◽  
Richard Watson ◽  
Kalipada Pahan
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Dopaminergic Neurons

Montelukast treatment protects nigral dopaminergic neurons against microglial activation in the 6-hydroxydopamine mouse model of Parkinson’s disease

Neuroreport ◽  
2017 ◽  
Vol 28 (5) ◽  
pp. 242-249 ◽  
Author(s):  
Hannah Jang ◽  
Sehwan Kim ◽  
Jae Man Lee ◽  
Yong-Seok Oh ◽  
Sang Myun Park ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Dopaminergic Neurons ◽  
Microglial Activation ◽  
6 Hydroxydopamine

Effect of monocrotophos, an organophosphorus insecticide, on the striatal dopaminergic system in a mouse model of Parkinson’s disease

2014 ◽  
Vol 32 (7) ◽  
pp. 1153-1165 ◽  
Author(s):  
Shaheen Jafri Ali ◽  
Padmanabhan Sharda Rajini
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Dopaminergic Neurons ◽  
Dopaminergic System ◽  
Nigrostriatal System ◽  
Low Concentrations ◽  
Repeated Doses ◽  
Mouse Model System ◽  
Neurobehavioral Deficits

Our earlier study had shown that low concentrations of monocrotophos (MCP) elicited dopaminergic features of Parkinson’s disease (PD) in the nematode Caenorhabditis elegans. In the present study, the effect of low doses of MCP on the striatal dopaminergic neurons was investigated using the mouse model system. MCP was initially screened for its ability to cause any neurobehavioral deficits and alterations in the dopaminergic system in Swiss albino mice, aged 8 weeks and weighing 25–30 g, with repeated doses at 0.3 and 0.6 mg/kg body weight (b.w.)/day for 7 days and 30 days. Mice were treated with four intraperitoneal injections for every 2 h with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) at the dosage of 14 mg/kg b.w. MCP was administered to these mice at the above-mentioned doses for 7 days. Mice administered with MCP alone revealed a significant ( p < 0.05) reduction in the dopamine (DA) content at both 7 and 30 days and showed a significant ( p < 0.05) increase in neurobehavioral deficits. Interestingly, when MCP was administered for 7 days to MPTP-treated mice, further significant decrease in both DA content and increase in neurobehavioral deficits were apparent. The extent of reactive oxygen species and lipid peroxidation were markedly increased, while the ratio of reduced to oxidized glutathione levels were significantly decreased ( p < 0.05) in the treated mice as compared to the control. Significant histopathological alterations and a marked reduction in the number of tyrosine hydroxylase positive cells were evident in striatum of mice treated with higher doses of MCP. These changes were comparable to that seen in mice treated with MPTP and post-administered lower doses of MCP. Our findings suggest that MCP per se has the propensity to induce pathological changes in the dopaminergic neurons as well as augment the degeneration in a compromised nigrostriatal system such as that in PD.

scholarly journals PEP-1-HO-1 prevents MPTP-induced degeneration of dopaminergic neurons in a Parkinson's disease mouse model

BMB Reports ◽  
2014 ◽  
Vol 47 (10) ◽  
pp. 569-574 ◽  
Author(s):  
Jong Kyu Youn ◽  
Dae Won Kim ◽  
Seung Tae Kim ◽  
Sung Yeon Park ◽  
Eun Ji Yeo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Dopaminergic Neurons
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