Anethum graveolens Essential Oil Encapsulation in Chitosan Nanomatrix: Investigations on In Vitro Release Behavior, Organoleptic Attributes, and Efficacy as Potential Delivery Vehicles Against Biodeterioration of Rice (Oryza sativa L.)

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Abhishek Kumar Dwivedy ◽  
Anand Kumar Chaudhari ◽  
Nawal Kishore Dubey
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pp. 101173 ◽  
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Márcio Vinícius Gomes ◽  
Lucio Mendes Cabral ◽  
Valeria Pereira de Sousa

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Vol 103 ◽  
pp. 94-100 ◽  
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Maryam Salami ◽  
Shima Momen ◽  
Farhad Alavi ◽  
Zahra Emam-Djomeh

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Antti Yli-Urpo

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Vol 157 (2-3) ◽  
pp. 598-604 ◽  
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Xianggui Kong ◽  
Shuxian Shi ◽  
Jingbin Han ◽  
Fengjie Zhu ◽  
Min Wei ◽  
...  

2021 ◽  
Vol 14 (10) ◽  
pp. 1033
Author(s):  
Lupe Carolina Espinoza ◽  
Lilian Sosa ◽  
Paulo C. Granda ◽  
Nuria Bozal ◽  
Natalia Díaz-Garrido ◽  
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The higher molecular weight and low solubility of amphotericin B (AmB) hinders its topical administration. The aim of this study was to incorporate Bursera graveolens essential oil into an AmB topical gel (AmB + BGEO gel) in order to promote the diffusion of the drug through the skin in the treatment of cutaneous candidiasis. AmB + BGEO gel formulation was determined using a factorial experiment. Physical and chemical parameters, stability, in vitro release profile and ex vivo permeation in human skin were evaluated. In vitro antimicrobial activity was studied using strains of C. albicans, C. glabrata and C. parapsilosis. The tolerability was evaluated using in vitro and in vivo models. AmB + BGEO gel presented appropriate characteristics for topical administration, including pH of 5.85, pseudoplastic behavior, optimal extensibility, as well as high stability and acceptable tolerability. In vitro release studies showed that the formulation releases the drug following a Boltzmann sigmoidal model. Finally, AmB + BGEO gel exhibited higher amount of drug retained inside the skin and lower Minimum Inhibitory Concentration than a formulation sans essential oil. Therefore, these results suggest that the incorporation of B. graveolens essential oil in the formulation could be used as strategy to promote a local effect in the treatment of cutaneous candidiasis.


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Vol 3 (3) ◽  
pp. 203-211 ◽  
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Kalyani Sakure ◽  
Kartik Nakhate ◽  
Hemant Dhongde ◽  
Pranita Kashayap ◽  
...  

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