scholarly journals Low-intensity Pulsed Ultrasound Enhances Bone Repair in a Rabbit Model of Steroid-associated Osteonecrosis

2015 ◽  
Vol 473 (5) ◽  
pp. 1830-1839 ◽  
Author(s):  
Hanxiao Zhu ◽  
Xunzi Cai ◽  
Tiao Lin ◽  
Zhongli Shi ◽  
Shigui Yan
Keyword(s):  
Bone Repair ◽  
Rabbit Model ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity

Low-intensity Pulsed Ultrasound Does Not Enhance Distraction Callus in a Rabbit Model

2007 ◽  
Vol 459 ◽  
pp. 237-245 ◽  
Author(s):  
Kenneth F Taylor ◽  
Bahman Rafiee ◽  
John E Tis ◽  
Nozumu Inoue
Keyword(s):  
Rabbit Model ◽  
Pulsed Ultrasound ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity

A Critical Assessment of the Clinical Efficacy and Cellular Response to Low Intensity Pulsed Ultrasound for Fracture Repair

2010 ◽  
Vol 76 ◽  
pp. 195-206
Author(s):  
Cato T. Laurencin ◽  
Yusuf Khan
Keyword(s):  
Cellular Response ◽  
Large Scale ◽  
Bone Repair ◽  
Fracture Repair ◽  
Great Promise ◽  
Pulsed Ultrasound ◽  
Invasive Treatment ◽  
In Vivo Evaluation ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity

Fracture repair continues to be widely investigated, both within the clinical realm and at the fundamental research level. Clinical application of low intensity pulsed ultrasound (LIPUS) has shown great promise as an effective, minimally invasive treatment for accelerating fracture repair and has warranted further investigation into the cellular manifestation of applied ultrasound. Toward this end much has been learned about the response of osteoblasts to LIPUS stimulation. In vitro and in vivo evaluation of cellular response to LIPUS have revealed an increase in proliferation, protein synthesis, collagen synthesis, membrane permeability, integrin expression, and increased cytosolic calcium, to name a few, further clarifying its utility and overall impact on cellular behavior. Considerable effects of LIPUS on the cells of musculoskeletal soft tissue have been reported as well. The growing body of research in this area suggests that LIPUS may be a powerful tool in the development of novel approaches to musculoskeletal repair and regeneration. Regenerative engineering-based approaches to musculoskeletal healing and regeneration that incorporate polymeric scaffolds and stem cells may be combined with LIPUS to move beyond bone repair to large scale multicomponent tissue repair.

Effect of Low-Intensity Pulsed Ultrasound After Autologous Adipose-Derived Stromal Cell Transplantation for Bone-Tendon Healing in a Rabbit Model

2019 ◽  
Vol 47 (4) ◽  
pp. 942-953 ◽  
Author(s):  
Can Chen ◽  
Tao Zhang ◽  
Fei Liu ◽  
Jin Qu ◽  
Yang Chen ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Volume Fraction ◽  
Treatment Time ◽  
Rabbit Model ◽  
The Other ◽  
Pulsed Ultrasound ◽  
Trabecular Thickness ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity

Background: Low-intensity pulsed ultrasound (LIPUS), as a safe biophysiotherapy, can enhance bone-tendon (B-T) healing in vivo and induce osteogenic or chondrogenic differentiation of mesenchymal stromal cells in vitro. This study aimed to determine whether LIPUS can improve the efficacy of transplanted mesenchymal stromal cells on B-T healing. Hypothesis: LIPUS can induce lineage-specific differentiation of transplanted adipose-derived stromal cells (ASCs) at the B-T healing site, thus resulting in superior healing quality when compared with LIPUS or ASCs alone. Study Design: Controlled laboratory study. Methods: A total of 112 mature rabbits with partial patellectomy in the hindlimb were randomly assigned into mock sonication without ASCs (control), ultrasonication without ASCs (LIPUS), mock sonication with ASCs (ASCs), and ultrasonication with ASCs (LIPUS + ASCs). The treatment time of the mock sonication or ultrasonication was 20 minutes per day. Autologous ASCs were transplanted to the healing site by fibrin glue during the operation, and LIPUS was delivered daily starting at postoperative day 3 until euthanasia. The patella–patellar tendon junctions were postoperatively harvested at 8 and 16 weeks for radiological, histological, and mechanical evaluations. Additionally, 9 animals were used for ASC tracking with mCherry protein. Results: Radiologically, there was more new bone formation and remodeling in the LIPUS + ASCs group as compared with the other groups. Synchrotron radiation micro–computed tomography showed that the LIPUS + ASCs group significantly increased bone volume fraction, trabecular thickness, and trabecular number at the healing site as compared with the other groups at postoperative 8 weeks ( P < .05 for all). Histologically, immunohistochemical staining confirmed that the transplanted mCherry-ASCs can differentiate into osteoblasts and fibrochondrocytic-like cells. Meanwhile, as compared with the other groups, the LIPUS + ASCs group showed more formation and maturity of the fibrocartilage layer and new bone at postoperative weeks 8 and 16 ( P < .05 for all). Biomechanically, the LIPUS + ASCs group showed significantly higher failure load and stiffness versus the other groups at postoperative weeks 8 and 16 ( P < .05 for all). Conclusion: Autologous ASC transplantation stimulated with LIPUS can result in superior B-T healing quality when compared with LIPUS or ASCs alone. Clinical Relevance: This study demonstrates the effectiveness of using ASC transplantation stimulated with LIPUS for B-T healing and provides a foundation for future clinical studies.

Low-intensity pulsed ultrasound repair in mandibular condylar cartilage injury rabbit model

2019 ◽  
Vol 104 ◽  
pp. 60-66 ◽  
Author(s):  
Hang-yu Zhou ◽  
Qiang Li ◽  
Jian-xiong Wang ◽  
Yu-jie Xie ◽  
Shi-qi Wang ◽  
...  
Keyword(s):  
Rabbit Model ◽  
Cartilage Injury ◽  
Pulsed Ultrasound ◽  
Condylar Cartilage ◽  
Low Intensity Pulsed Ultrasound ◽  
Low Intensity ◽  
Mandibular Condylar Cartilage
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