The Role of Zinc Status on Spatial Memory, Hippocampal Synaptic Plasticity, and Insulin Signaling in icv-STZ-Induced Sporadic Alzheimer’s-Like Disease in Rats

2021 ◽  
Author(s):  
Saltuk Bugra Baltaci ◽  
Omer Unal ◽  
Elif Gulbahce-Mutlu ◽  
Haluk Gumus ◽  
Suray Pehlivanoglu ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Spatial Memory ◽  
Insulin Signaling ◽  
Zinc Status ◽  
Hippocampal Synaptic Plasticity

scholarly journals Cornichon Homolog-3 (CNIH3) Modulates Spatial Memory in Female Mice

2019 ◽  
Author(s):  
Hannah E. Frye ◽  
Sidney B. Williams ◽  
Christopher R. Trousdale ◽  
Elliot C. Nelson ◽  
Joseph D. Dougherty ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Spatial Memory ◽  
Dorsal Hippocampus ◽  
Postsynaptic Membrane ◽  
Spatial Learning And Memory ◽  
Female Mice ◽  
Specific Effects ◽  
Hippocampal Synaptic Plasticity ◽  
Auxiliary Protein

ABSTRACTCornichon homolog-3 (CNIH3) is an AMPA receptor (AMPAR) auxiliary protein that traffics AMPARs to the postsynaptic membrane and potentiates AMPAR signaling. AMPARs are key components of hippocampal synaptic plasticity and memory formation, however the role of CNIH3 in memory has yet to be elucidated. To study the role of CNIH3 on mouse behavior, we bred and characterized a line of Cnih3-/- mice from C57BL/6 Cnih3tm1a(KOMP)Wtsi mice obtained from the Knockout Mouse Project (KOMP). In agreement with previous studies of CNIH3 in the brain, we observed concentrated expression of Cnih3 in the dorsal hippocampus, a region associated with spatial learning and memory. Therefore, we tested Cnih3+/+, Cnih3+/-, and Cnih3-/- mice in the Barnes maze paradigm to measure spatial memory. We observed no change in spatial memory in male Cnih3+/- and Cnih3-/- mice compared to male Cnih3+/+ controls, however, Cnih3-/- female mice made significantly more primary errors, had a higher primary latency, and took less efficient routes to the target in the maze compared to Cnih3+/+ female mice. Next, to investigate an enhancement of spatial memory by Cnih3 overexpression, specifically in the dorsal hippocampus, we developed an AAV5 viral construct to express wild-type Cnih3 in excitatory neurons. Female mice overexpressing Cnih3 made significantly fewer errors, had a lower primary latency to the target, and took more efficient routes to the maze target compared to YFP expressing control females. No change in spatial memory was observed in male Cnih3 overexpression mice. This study, the first to identify sex-specific effects of the AMPAR auxiliary protein CNIH3 on spatial memory, provides the groundwork for future studies investigating the role of CNIH3 on sexually dimorphic AMPAR-dependent behavior and hippocampal synaptic plasticity.

P1-155: Role of the BDNF Val66Met polymorphism in hippocampal synaptic plasticity

2010 ◽  
Vol 6 ◽  
pp. S219-S219
Author(s):  
Ipe Ninan ◽  
Karishma Dagar ◽  
Rosalia Perez-Castro ◽  
Mark R. Plummer ◽  
Francis S. Lee ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Val66met Polymorphism ◽  
Hippocampal Synaptic Plasticity ◽  
Bdnf Val66met Polymorphism

The Role of Proteases in Hippocampal Synaptic Plasticity: Putting Together Small Pieces of a Complex Puzzle

2015 ◽  
Vol 41 (1-2) ◽  
pp. 156-182 ◽  
Author(s):  
Ivan L. Salazar ◽  
Margarida V. Caldeira ◽  
Michele Curcio ◽  
Carlos B. Duarte
Keyword(s):  
Synaptic Plasticity ◽  
Hippocampal Synaptic Plasticity

scholarly journals The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory

Cell ◽  
1996 ◽  
Vol 87 (7) ◽  
pp. 1327-1338 ◽  
Author(s):  
Joe Z Tsien ◽  
Patricio T Huerta ◽  
Susumu Tonegawa
Keyword(s):  
Synaptic Plasticity ◽  
Nmda Receptor ◽  
Spatial Memory ◽  
Essential Role ◽  
Hippocampal Ca1

scholarly journals Correction to: Selective role of the translin/trax RNase complex in hippocampal synaptic plasticity

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Alan Jung Park ◽  
Mahesh Shivarama Shetty ◽  
Jay M. Baraban ◽  
Ted Abel
Keyword(s):  
Synaptic Plasticity ◽  
Hippocampal Synaptic Plasticity

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