Therapeutic Effects of Boric Acid in a Septic Arthritis Model Induced by Escherichia coli in Rats

2022 ◽  
Author(s):  
Kadri Yıldız ◽  
Mustafa Makav ◽  
Yasemin Adalı ◽  
Menekşe Bulut
Keyword(s):  
Escherichia Coli ◽  
Septic Arthritis ◽  
Boric Acid ◽  
Therapeutic Effects ◽  
Arthritis Model

Therapeutic Effects of High Molecular Weight Hyaluronic Acid in Severe Pseudomonas Aeruginosa Pneumonia in Ex Vivo Perfused Human Lungs

2021 ◽  
Author(s):  
Xiwen Zhang ◽  
Shinji Sugita ◽  
Airan Liu ◽  
Yoshifumi Naito ◽  
Wonjung Hwang ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Molecular Weight ◽  
Pseudomonas Aeruginosa ◽  
Hyaluronic Acid ◽  
High Molecular Weight ◽  
Bacterial Pneumonia ◽  
Ex Vivo ◽  
Therapeutic Effects ◽  
Human Lungs ◽  
Protein Permeability

Introduction: We previously reported that extracellular vesicles (EVs) released during Escherichia coli bacterial pneumonia were inflammatory, and administration of high molecular weight hyaluronic acid (HMW HA) suppressed several indices of acute lung injury (ALI) from Escherichia coli pneumonia by binding to these inflammatory EVs. The current study was undertaken to study the therapeutic effects of HMW HA in ex vivo perfused human lungs injured with Pseudomonas aeruginosa (PA)103 bacterial pneumonia. Methods: For lungs with baseline alveolar fluid clearance (AFC)<10%/h, HMW HA 1 or 2 mg was injected intravenously after 1 h (N = 4-9), and EVs released during PA pneumonia were collected from the perfusate over 6 h. For lungs with baseline AFC>10%/h, HMW HA 2 mg was injected intravenously after 1 h (N = 6). In vitro experiments were conducted to evaluate the effects of HA on inflammation and bacterial phagocytosis. Results: For lungs with AFC<10%/h, administration of HMW HA intravenously significantly restored AFC and numerically decreased protein permeability and alveolar inflammation from PA103 pneumonia but had no effect on bacterial counts at 6 h. However, HMW HA improved bacterial phagocytosis by human monocytes and neutrophils and suppressed the inflammatory properties of EVs released during pneumonia on monocytes. For lungs with AFC>10%/h, administration of HMW HA intravenously improved AFC from PA103 pneumonia but had no significant effects on protein permeability, inflammation or bacterial counts. Discussion: In the presence of impaired alveolar epithelial transport capacity, administration of HMW HA improved the resolution of pulmonary edema from Pseudomonas PA103 bacterial pneumonia.

Therapeutic effects of resveratrol in Escherichia coli-induced rat endometritis model

2019 ◽  
Vol 392 (12) ◽  
pp. 1577-1589 ◽  
Author(s):  
Murside Ayse Demirel ◽  
Sevtap Han ◽  
Aytekin Tokmak ◽  
Nilufer Ercan Gokay ◽  
Mecit Orhan Uludag ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Therapeutic Effects

MRI-assessed therapeutic effects of locally administered PLGA nanoparticles loaded with anti-inflammatory siRNA in a murine arthritis model

2012 ◽  
Vol 161 (3) ◽  
pp. 772-780 ◽  
Author(s):  
Bernard C.M. te Boekhorst ◽  
Linda B. Jensen ◽  
Stefano Colombo ◽  
Amir K. Varkouhi ◽  
Raymond M. Schiffelers ◽  
...  
Keyword(s):  
Plga Nanoparticles ◽  
Therapeutic Effects ◽  
Arthritis Model ◽  
Anti Inflammatory

Mechanisms for Lactobacillus rhamnosus treatment of intestinal infection by drug-resistant Escherichia coli

2020 ◽  
Vol 11 (5) ◽  
pp. 4428-4445 ◽  
Author(s):  
Na Li ◽  
Bing Pang ◽  
Junjun Li ◽  
Guanwen Liu ◽  
Xiaoguang Xu ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Lactobacillus Rhamnosus ◽  
Multiple Drug ◽  
Therapeutic Effects ◽  
Drug Resistant ◽  
Intestinal Infection ◽  
E Coli ◽  
Intestinal Integrity ◽  
Multiple Drug Resistant

Reducing the viability of pathogens may also play an important role for the therapeutic effects of Lactobacillus rhamnosus SHA113 against multiple-drug-resistant E. coli, as well as influencing on the intestinal integrity and functions of animals.

Effect of intraarticular propolis in an experimental septic arthritis model

2011 ◽  
Vol 20 (1) ◽  
pp. 8-13 ◽  
Author(s):  
Mithat Oner ◽  
Ibrahim Kafadar ◽  
Ahmet Guney ◽  
Mehmet Halici ◽  
Kemal Deniz ◽  
...  
Keyword(s):  
Septic Arthritis ◽  
Arthritis Model
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