Serum IGF-binding protein 2 (IGFBP-2) concentrations change early after gastric bypass bariatric surgery revealing a possible marker of leptin sensitivity in obese subjects

Endocrine ◽  
2019 ◽  
Vol 65 (1) ◽  
pp. 86-93 ◽  
Author(s):  
Giovanni Ceccarini ◽  
Caterina Pelosini ◽  
Federica Ferrari ◽  
Silvia Magno ◽  
Jacopo Vitti ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Gastric Bypass ◽  
Binding Protein ◽  
Leptin Sensitivity ◽  
Igf Binding ◽  
Obese Subjects ◽  
Igf Binding Protein

scholarly journals Effects of Gastric Sleeve Surgery on the Serum Levels of GH, IGF-1 and IGF-binding Protein 2 in Healthy Obese Patients

2020 ◽  
Author(s):  
Khalid Al-Regaiey ◽  
Suad Alshubrami ◽  
Ibrahim Al-Beeshi ◽  
Torki Alnasser ◽  
Abdulnasser Alwabel ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Lipid Profile ◽  
Profile Analysis ◽  
Binding Protein ◽  
Density Lipoprotein ◽  
Gastric Sleeve ◽  
Igf Binding ◽  
Gastric Sleeve Surgery ◽  
Healthy Obese ◽  
Igf Binding Protein

Abstract Background Bariatric surgery is an effective treatment for severe obesity. It also ameliorates diabetes independently of weight loss through mechanisms that are not fully understood. In this study, we investigated the levels of GH, IGF-1 and IGF-binding protein 2 (IGFBP-2) after gastric sleeve surgery in healthy obese individuals. Method This study was conducted in 33 obese (BMI > 38.3) healthy male subjects aged 25 to 50 years undergoing sleeve gastrectomy. GH, IGF-1 and IGFBP-2 levels were evaluated by ELISA at baseline and 6-12 months after surgery. Other parameters, such as glucose, BMI, insulin, HOMA-IR and lipid profile, were also investigated. Results Systemic GH (12.32 vs. 50.97 pg/mL, p < 0.001) and IGFBP-2 levels (51.86 vs. 68.81 pg/mL, p < 0.001) were elevated after bariatric surgery. There was no change in IGF-1 level from before to after surgery. BMI (52.18 vs. 40.11, p = 0.001), insulin (19.35 vs. 8.80 mIU/L, p < 0.001) and HOMA-IR index (6.48 to 2.52, p < 0.001) were reduced after surgery. Lipid profile analysis revealed that total cholesterol (4.26 vs. 5.12 mmol/L, p < 0.001) and high-density lipoprotein (HDL) (0.90 to 1.55 mmol/L, p < 0.001) were increased, while triglycerides were decreased, after surgery (1.62 vs. 1.05 mmol/L p < 0.001). GH, IGF-1, and IGFBP-2 were not correlated with insulin or lipid parameters. Conclusions Our study suggests that improved circulating GH and IGFBP-2 levels may mediate the beneficial effects of gastric sleeve surgery in improving insulin sensitivity and reducing insulin demand.

scholarly journals Effects of Gastric Sleeve Surgery in the Serum Levels of GH, IGF-1 and IGF-binding Protein 2 in Morbidly Obese Patients

2019 ◽  
Author(s):  
Khalid Al-Regaiey ◽  
Suad Alshubrami ◽  
Ibrahim Al-Beeshi ◽  
Torki Alnasser ◽  
Abdulnasser Alwabel ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Binding Protein ◽  
High Density Lipoproteins ◽  
Calorie Intake ◽  
Morbidly Obese ◽  
Model Assessment ◽  
Gastric Sleeve ◽  
Igf Binding ◽  
Gastric Sleeve Surgery ◽  
Igf Binding Protein

Abstract Background Bariatric or weight loss surgery is an effective treatment for severe obesity. Reduced calorie intake or malabsorption are not the only mechanism, alterations in the activity of certain hormones and neurotransmitters are also the contributory mechanisms. In this study, we investigated the levels of GH, IGF-1 and IGF-binding protein (IGFBP-2) after bariatric surgery in obese individuals.Method Plasma GH, IGF-1 and IGFBP-2 levels were measured by ELISA in 33 obese (BMI >38.3) healthy male subjects age ranged from 25 to 50 years before and six months after gastric sleeve surgery. Plasma glucose, BMI, insulin, HOMA-IR and lipid profile were also investigated.Results Systemic GH (from 12.32±1.3 to 50.97±0.339 ρg/mL, P<0.001) and IGFBP-2 (51.86±11.21 to 68.81±13.36 ρg/mL, P<0.001) levels were elevated after bariatric surgery. However there was no change in IGF-1 levels. BMI (from 52.18±9.86 Kg/m2 to 40.11±8.92 Kg/m2, P<0.001), insulin (19.35±0.304 mIU/L to 8.80±0.181 mIU/L, P<0.001) and Homeostatic model assessment- Insulin resistance (HOMA-IR) index was also reduced from 6.48+0.164 to 2.52 ± 0.061 (p<0.001) were also reduced 6 months after bariatric surgery. Cholesterol, high density lipoproteins (HDL), and low density lipoproteins (LDL) levels were increased after surgery (4.26±0.027 to 5.12±0.026 mmol/L and 0.90±0.007 to 1.55±0.011 mmol/L and 2.62±0.02 to 2.98±0.022 mmol/L, P<0.001) respectively. There was no correlation between GH, IGF-1, IGFBP-2and insulin and lipid parameters.Conclusions Our study suggests that improved circulating GH and IGFBP-2 levels associated with increased levels cholesterol and triglycerides may be an endocrine response to mediate beneficial effects of bariatric surgery.

scholarly journals Effects of Gastric Sleeve Surgery on the Serum Levels of GH, IGF-1 and IGF-binding Protein 2 in Morbidly Obese Patients

2020 ◽  
Author(s):  
Khalid Al-Regaiey ◽  
Suad Alshubrami ◽  
Ibrahim Al-Beeshi ◽  
Torki Alnasser ◽  
Abdulnasser Alwabel ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Lipid Profile ◽  
Profile Analysis ◽  
Binding Protein ◽  
Density Lipoprotein ◽  
Morbidly Obese ◽  
Gastric Sleeve ◽  
Igf Binding ◽  
Gastric Sleeve Surgery ◽  
Igf Binding Protein

Abstract Background Bariatric surgery is an effective treatment for severe obesity. It also ameliorates diabetes independently of weight loss through mechanisms that are not fully understood. In this study, we investigated the levels of GH, IGF-1 and IGF-binding protein (IGFBP-2) after gastric sleeve surgery in healthy obese individuals. Method This study was conducted in 33 obese (BMI >38.3) healthy male subjects aged 25 to 50 years undergoing sleeve gastrectomy. GH, IGF-1 and IGFBP-2 levels were evaluated by ELISA at baseline and 6-12 months after surgery. Other parameters, such as glucose, BMI, insulin, HOMA-IR and lipid profile, were also investigated. Results Systemic GH (12.32 vs. 50.97 pg/mL, p < 0.001) and IGFBP-2 levels (51.86 vs. 68.81 pg/mL, p < 0.001) were elevated after bariatric surgery. There was no change in IGF-1 level from before to after surgery. BMI (52.18 vs. 40.11, p = 0.001), insulin (19.35 vs. 8.80 mIU/L, p < 0.001) and HOMA-IR index (6.48 to 2.52, p < 0.001) were reduced after surgery. Lipid profile analysis revealed that total cholesterol (4.26 vs. 5.12 mmol/L, p < 0.001) and high-density lipoprotein (HDL) (0.90 to 1.55 mmol/L, p < 0.001) were increased, while triglycerides were decreased, after surgery (1.62 vs. 1.05 mmol/L p < 0.001). GH, IGF-1, and IGFBP-2 were not correlated with insulin or lipid parameters. Conclusions Our study suggests that improved circulating GH and IGFBP-2 levels may mediate the beneficial effects of gastric sleeve surgery in improving insulin sensitivity and reducing insulin demand.

scholarly journals Effects of Gastric Sleeve Surgery on the Serum Levels of GH, IGF-1 and IGF-binding Protein 2 in Morbidly Obese Patients

2020 ◽  
Author(s):  
Khalid Al-Regaiey ◽  
Suad Alshubrami ◽  
Ibrahim Al-Beeshi ◽  
Torki Alnasser ◽  
Abdulnasser Alwabel ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Lipid Profile ◽  
Profile Analysis ◽  
Binding Protein ◽  
Density Lipoprotein ◽  
Morbidly Obese ◽  
Gastric Sleeve ◽  
Igf Binding ◽  
Gastric Sleeve Surgery ◽  
Igf Binding Protein

Abstract Background Bariatric surgery is an effective treatment for severe obesity. It also ameliorates diabetes independently of weight loss through mechanisms that are not fully understood. In this study, we investigated the levels of GH, IGF-1 and IGF-binding protein 2 (IGFBP-2) after gastric sleeve surgery in healthy obese individuals. Method This study was conducted in 33 obese (BMI > 38.3) healthy male subjects aged 25 to 50 years undergoing sleeve gastrectomy. GH, IGF-1 and IGFBP-2 levels were evaluated by ELISA at baseline and 6-12 months after surgery. Other parameters, such as glucose, BMI, insulin, HOMA-IR and lipid profile, were also investigated. Results Systemic GH (12.32 vs. 50.97 pg/mL, p < 0.001) and IGFBP-2 levels (51.86 vs. 68.81 pg/mL, p < 0.001) were elevated after bariatric surgery. There was no change in IGF-1 level from before to after surgery. BMI (52.18 vs. 40.11, p = 0.001), insulin (19.35 vs. 8.80 mIU/L, p < 0.001) and HOMA-IR index (6.48 to 2.52, p < 0.001) were reduced after surgery. Lipid profile analysis revealed that total cholesterol (4.26 vs. 5.12 mmol/L, p < 0.001) and high-density lipoprotein (HDL) (0.90 to 1.55 mmol/L, p < 0.001) were increased, while triglycerides were decreased, after surgery (1.62 vs. 1.05 mmol/L p < 0.001). GH, IGF-1, and IGFBP-2 were not correlated with insulin or lipid parameters. Conclusions Our study suggests that improved circulating GH and IGFBP-2 levels may mediate the beneficial effects of gastric sleeve surgery in improving insulin sensitivity and reducing insulin demand.

The clinical values of IGF1 and IGF-binding protein-3 levels in blood and thyroid nodules

2014 ◽  
Author(s):  
Ayfer Altas ◽  
Fatih Kuzu ◽  
Gurkan Haytaoglu ◽  
Murat Can ◽  
Figen Barut ◽  
...  
Keyword(s):  
Thyroid Nodules ◽  
Binding Protein ◽  
Igf Binding ◽  
Igf Binding Protein
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