HR-HPV viral load quality detection provide more accurate prediction for residual lesions after treatment: a prospective cohort study in patients with high-grade squamous lesions or worse

2020 ◽  
Vol 37 (5) ◽  
Author(s):  
Lihua Chen ◽  
Binhua Dong ◽  
Qiaoyu Zhang ◽  
Xiaodan Mao ◽  
Wenyu Lin ◽  
...  
Author(s):  
Teppei Sakano ◽  
Mitsuyoshi Urashima ◽  
Hiroyuki Takao ◽  
Kohei Takeshita ◽  
Hiroe Kobashi ◽  
...  

In the coronavirus disease 2019 (COVID-19) pandemic, more than half of the cases of transmission may occur via asymptomatic individuals, which makes it difficult to contain. However, whether viral load in the throat during admission is different between asymptomatic and symptomatic patients is not well known. By conducting a prospective cohort study of patients with asymptomatic or mild COVID-19, cycle threshold (Ct) values of the polymerase chain reaction test for COVID-19 were examined every other day during admission. The Ct values during admission increased more steadily in symptomatic patients and febrile patients than in asymptomatic patients, with significance (p = 0.01 and p = 0.004, respectively), although the Ct values as a whole were not significantly different between the two groups. Moreover, the Ct values as a whole were higher in patients with dysosmia/dysgeusia than in those without it (p = 0.02), whereas they were lower in patients with a headache than those without (p = 0.01). Patients who were IgG-positive at discharge maintained higher Ct values, e.g., more than 35, during admission than those with IgG-negative (p = 0.03). Assuming that viral load and Ct values are negatively associated, the viral loads as a whole and their changes by time may be different by symptoms and immune reaction, i.e., IgG-positive at discharge.


2019 ◽  
Vol 2 (4) ◽  
pp. 190-198
Author(s):  
Clara Van Ommen ◽  
Arianne Albert ◽  
Melica Nourmoussavi ◽  
Reka Gustafson ◽  
Elizabeth Brodkin ◽  
...  

2020 ◽  
Vol 7 (3) ◽  
pp. e184-e192 ◽  
Author(s):  
Kunjal Patel ◽  
Brad Karalius ◽  
Kathleen Powis ◽  
Deborah Kacanek ◽  
Claire Berman ◽  
...  

AIDS Care ◽  
2016 ◽  
Vol 29 (4) ◽  
pp. 469-480 ◽  
Author(s):  
M. Reuel Friedman ◽  
Robert W.S. Coulter ◽  
Anthony J. Silvestre ◽  
Ron Stall ◽  
Linda Teplin ◽  
...  

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