Backbone NMR resonance assignments of the nucleotide binding domain of the ABC multidrug transporter LmrA from Lactococcus lactis in its ADP-bound state

2011 ◽  
Vol 6 (1) ◽  
pp. 69-73 ◽  
Author(s):  
Ute A. Hellmich ◽  
Elke Duchardt-Ferner ◽  
Clemens Glaubitz ◽  
Jens Wöhnert
Keyword(s):  
Lactococcus Lactis ◽  
Resonance Assignments ◽  
Nucleotide Binding ◽  
Bound State ◽  
Nmr Resonance Assignments ◽  
Binding Domain ◽  
Multidrug Transporter ◽  
Nucleotide Binding Domain

scholarly journals Solid-state NMR [13C,15N] resonance assignments of the nucleotide-binding domain of a bacterial cyclic nucleotide-gated channel

2012 ◽  
Vol 6 (2) ◽  
pp. 225-229 ◽  
Author(s):  
Abhishek Cukkemane ◽  
Deepak Nand ◽  
Sabine Gradmann ◽  
Markus Weingarth ◽  
U. Benjamin Kaupp ◽  
...  
Keyword(s):  
Solid State ◽  
Cyclic Nucleotide ◽  
Solid State Nmr ◽  
Resonance Assignments ◽  
Nucleotide Binding ◽  
Binding Domain ◽  
Nucleotide Binding Domain ◽  
Gated Channel

scholarly journals Mutations Define Cross-talk between the N-terminal Nucleotide-binding Domain and Transmembrane Helix-2 of the Yeast Multidrug Transporter Pdr5

2008 ◽  
Vol 283 (50) ◽  
pp. 35010-35022 ◽  
Author(s):  
Zuben E. Sauna ◽  
Sherry Supernavage Bohn ◽  
Robert Rutledge ◽  
Michael P. Dougherty ◽  
Susan Cronin ◽  
...  
Keyword(s):  
Cross Talk ◽  
Transmembrane Helix ◽  
Nucleotide Binding ◽  
Binding Domain ◽  
Multidrug Transporter ◽  
Nucleotide Binding Domain ◽  
Terminal Nucleotide

scholarly journals Backbone NMR assignment of the nucleotide binding domain of the Bacillus subtilis ABC multidrug transporter BmrA in the post-hydrolysis state

2022 ◽  
Author(s):  
Victor Hugo Pérez Carrillo ◽  
Dania Rose-Sperling ◽  
Mai Anh Tran ◽  
Christoph Wiedemann ◽  
Ute A. Hellmich
Keyword(s):  
Bacillus Subtilis ◽  
Abc Transporter ◽  
Transmembrane Domain ◽  
Molecular Motor ◽  
Nucleotide Binding ◽  
Bound State ◽  
Binding Domain ◽  
Nucleotide Binding Domain ◽  
Backbone Chemical Shift ◽  
Nucleotide Interactions

AbstractATP binding cassette (ABC) proteins are present in all phyla of life and form one of the largest protein families. The Bacillus subtilis ABC transporter BmrA is a functional homodimer that can extrude many different harmful compounds out of the cell. Each BmrA monomer is composed of a transmembrane domain (TMD) and a nucleotide binding domain (NBD). While the TMDs of ABC transporters are sequentially diverse, the highly conserved NBDs harbor distinctive conserved motifs that enable nucleotide binding and hydrolysis, interdomain communication and that mark a protein as a member of the ABC superfamily. In the catalytic cycle of an ABC transporter, the NBDs function as the molecular motor that fuels substrate translocation across the membrane via the TMDs and are thus pivotal for the entire transport process. For a better understanding of the structural and dynamic consequences of nucleotide interactions within the NBD at atomic resolution, we determined the 1H, 13C and 15N backbone chemical shift assignments of the 259 amino acid wildtype BmrA-NBD in its post-hydrolytic, ADP-bound state.

Resonance assignments of the nucleotide-free wildtype MloK1 cyclic nucleotide-binding domain

2010 ◽  
Vol 4 (2) ◽  
pp. 147-150 ◽  
Author(s):  
Sven Schünke ◽  
Justin Lecher ◽  
Matthias Stoldt ◽  
U. Benjamin Kaupp ◽  
Dieter Willbold
Keyword(s):  
Cyclic Nucleotide ◽  
Resonance Assignments ◽  
Nucleotide Binding ◽  
Binding Domain ◽  
Nucleotide Binding Domain ◽  
Cyclic Nucleotide Binding ◽  
Cyclic Nucleotide Binding Domain

scholarly journals A possible nucleotide-binding domain in the tertiary fold of phosphoribosyltransferases.

1983 ◽  
Vol 258 (10) ◽  
pp. 6450-6457 ◽  
Author(s):  
P Argos ◽  
M Hanei ◽  
J M Wilson ◽  
W N Kelley
Keyword(s):  
Nucleotide Binding ◽  
Binding Domain ◽  
Nucleotide Binding Domain

Mutational Analysis of the Nucleotide Binding Domain of the Mismatch Repair Enzyme hMSH-2

1996 ◽  
Vol 229 (1) ◽  
pp. 147-153 ◽  
Author(s):  
Adrian Whitehouse ◽  
Rekha Parmar ◽  
Jayne Deeble ◽  
Graham R. Taylor ◽  
Simon E.V. Phillips ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Mutational Analysis ◽  
Nucleotide Binding ◽  
Binding Domain ◽  
Nucleotide Binding Domain ◽  
Repair Enzyme
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