Decumbenone C, a new cytotoxic decaline derivative from the marine fungus Aspergillus sulphureus KMM 4640

2012 ◽  
Vol 35 (10) ◽  
pp. 1757-1762 ◽  
Author(s):  
Olesya I. Zhuravleva ◽  
Shamil Sh. Afiyatullov ◽  
Olesya S. Vishchuk ◽  
Vladimir A. Denisenko ◽  
Natalya N. Slinkina ◽  
...  
Keyword(s):  
Marine Fungus ◽  
Aspergillus Sulphureus

scholarly journals Decumbenones A–C from marine fungus <i>Aspergillus sulphureus</i> as stimulators of the initial stages of development of agricultural plants

2012 ◽  
Vol 03 (08) ◽  
pp. 1019-1022 ◽  
Author(s):  
Mikhail M. Anisimov ◽  
Elena L. Chaikina ◽  
Shamil Sh. Afiyatullov ◽  
Olesya I. Zhuravleva ◽  
Alekxey G. Klykov ◽  
...  
Keyword(s):  
Marine Fungus ◽  
Stages Of Development ◽  
Aspergillus Sulphureus ◽  
Agricultural Plants

scholarly journals Cytotoxic alkaloids from the marine shellfish-associated fungus Aspergillus sp. XBB-4 induced by an amino acid-directed strategy

RSC Advances ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 4243-4250
Author(s):  
Yi Qiu ◽  
Qi Guo ◽  
Yan-Qin Ran ◽  
Wen-Jian Lan ◽  
Chi-Keung Lam ◽  
...  
Keyword(s):  
Amino Acid ◽  
Marine Fungus ◽  
Aspergillus Sp

Cytotoxic alkaloids from marine fungus Aspergillus sp. XBB-4 induced by an amino acid-directed strategy.

scholarly journals Specificities and Synergistic Actions of Novel PL8 and PL7 Alginate Lyases from the Marine Fungus Paradendryphiella salina

2021 ◽  
Vol 7 (2) ◽  
pp. 80
Author(s):  
Bo Pilgaard ◽  
Marlene Vuillemin ◽  
Jesper Holck ◽  
Casper Wilkens ◽  
Anne S. Meyer
Keyword(s):  
Alginate Lyase ◽  
Marine Fungus ◽  
Brown Macroalgae ◽  
Polysaccharide Lyases ◽  
Alginate Lyases ◽  
Encoding Genes ◽  
Substrate Affinities ◽  
Alginate Degradation ◽  
Insight Into

Alginate is an anionic polysaccharide abundantly present in the cell walls of brown macroalgae. The enzymatic depolymerization is performed solely by alginate lyases (EC 4.2.2.x), categorized as polysaccharide lyases (PLs) belonging to 12 different PL families. Until now, the vast majority of the alginate lyases have been found in bacteria. We report here the first extensive characterization of four alginate lyases from a marine fungus, the ascomycete Paradendryphiella salina, a known saprophyte of seaweeds. We have identified four polysaccharide lyase encoding genes bioinformatically in P. salina, one PL8 (PsMan8A), and three PL7 alginate lyases (PsAlg7A, -B, and -C). PsMan8A was demonstrated to exert exo-action on polymannuronic acid, and no action on alginate, indicating that this enzyme is most likely an exo-acting polymannuronic acid specific lyase. This enzyme is the first alginate lyase assigned to PL8 and polymannuronic acid thus represents a new substrate specificity in this family. The PL7 lyases (PsAlg7A, -B, and -C) were found to be endo-acting alginate lyases with different activity optima, substrate affinities, and product profiles. PsAlg7A and PsMan8A showed a clear synergistic action for the complete depolymerization of polyM at pH 5. PsAlg7A depolymerized polyM to mainly DP5 and DP3 oligomers and PsMan8A to dimers and monosaccharides. PsAlg7B and PsAlg7C showed substrate affinities towards both polyM and polyG at pH 8, depolymerizing both substrates to DP9-DP2 oligomers. The findings elucidate how P. salina accomplishes alginate depolymerization and provide insight into an efficient synergistic cooperation that may provide a new foundation for enzyme selection for alginate degradation in seaweed bioprocessing.

Penicilazaphilone C, a new antineoplastic and antibacterial azaphilone from the Marine Fungus Penicillium sclerotiorum

2016 ◽  
Vol 39 (12) ◽  
pp. 1621-1627 ◽  
Author(s):  
Song-lin Zhou ◽  
Min Wang ◽  
Huan-ge Zhao ◽  
Yong-hao Huang ◽  
Ying-ying Lin ◽  
...  
Keyword(s):  
Marine Fungus ◽  
Penicillium Sclerotiorum

Pestalone, a New Antibiotic Produced by a Marine Fungus in Response to Bacterial Challenge

2001 ◽  
Vol 64 (11) ◽  
pp. 1444-1446 ◽  
Author(s):  
Mercedes Cueto ◽  
Paul R. Jensen ◽  
Chris Kauffman ◽  
William Fenical ◽  
Emil Lobkovsky ◽  
...  
Keyword(s):  
Marine Fungus ◽  
Bacterial Challenge

scholarly journals Depsidone Derivatives and a Cyclopeptide Produced by Marine Fungus Aspergillus unguis under Chemical Induction and by Its Plasma Induced Mutant

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2245 ◽  
Author(s):  
Wen-Cong Yang ◽  
Hai-Yan Bao ◽  
Ya-Yue Liu ◽  
Ying-Ying Nie ◽  
Jing-Ming Yang ◽  
...  
Keyword(s):  
Cyclic Peptide ◽  
Docking Studies ◽  
Marine Fungus ◽  
Strong Interactions ◽  
Original Strain ◽  
Chemical Induction ◽  
Strong Activity ◽  
Hplc Fingerprint ◽  
Aspergillus Unguis ◽  
Induced Mutant

A new depsidone derivative (1), aspergillusidone G, was isolated from a marine fungus Aspergillus unguis, together with eight known depsidones (2‒9) and a cyclic peptide (10): agonodepside A (2), nornidulin (3), nidulin (4), aspergillusidone F (5), unguinol (6), aspergillusidone C (7), 2-chlorounguinol (8), aspergillusidone A (9), and unguisin A (10). Compounds 1‒4 and 7‒9 were obtained from the plasma induced mutant of this fungus, while 5, 6, and 10 were isolated from the original strain under chemical induction. Their structures were identified using spectroscopic analysis, as well as by comparison with literature data. The HPLC fingerprint analysis indicates that chemical induction and plasma mutagenesis effectively influenced the secondary metabolism, which may be due to their regulation in the key steps in depsidone biosynthesis. In bioassays, compound 9 inhibited acetylcholinesterase (AChE) with IC50 in 56.75 μM. Compounds 1, 5, 7, 8, and 9 showed moderate to strong activity towards different microbes. Compounds 3, 4, and 5 exhibited potent larvicidality against brine shrimp. In docking studies, higher negative CDOCKER interaction energy and richer strong interactions between AChE and 9 explained the greater activity of 9 compared to 1. Chemical induction and plasma mutagenesis can be used as tools to expand the chemodiversity of fungi and obtain useful natural products.

scholarly journals Restricticin B from the Marine Fungus Penicillium janthinellum and Its Inhibitory Activity on the NO Production in BV-2 Microglia Cells

2020 ◽  
Author(s):  
Byeonung-Kyu Choi ◽  
Shin-Young Park ◽  
Song-Hee Jo ◽  
Dong-Kug Choi ◽  
Phan Thi Hoai Trinh ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Optical Rotation ◽  
2D Nmr ◽  
Marine Fungus ◽  
No Production ◽  
Spectroscopy Data ◽  
Penicillium Janthinellum ◽  
Etoac Extract ◽  
Data Comparison ◽  
Nmr Data

A new compound containing a triene, a tetrahydropyran ring and glycine ester functionalities, restricticin B (1), together with four known compounds (2-5) were obtained from the EtOAc extract of the marine fungus Penicillium janthinellum. The planar structure of 1 was determined by detailed analyses of MS, 1D and 2D NMR data. The relative and absolute configurations of 1 were established via analyses of NOESY spectroscopy data, comparison of optical rotation values with those of restricticin derivatives reported and electronic circular dichroism (ECD). All the compounds were screened for their anti-neuroinflammatory effects in lipopolysaccharide (LPS)-induced BV-2 microglia cells. Restricticin B (1) and N-acetyl restricticin (2) exhibited anti-neuroinflammatory effects by suppressing the production of pro-inflammatory mediators in activated microglial cells.

Indole Alkaloids Produced by a Marine Fungus Isolate ofPenicillium janthinellumBiourge

2007 ◽  
Vol 70 (6) ◽  
pp. 906-909 ◽  
Author(s):  
Olga F. Smetanina ◽  
Anatoly I. Kalinovsky ◽  
Yuliya V. Khudyakova ◽  
Mikhail V. Pivkin ◽  
Pavel S. Dmitrenok ◽  
...  
Keyword(s):  
Indole Alkaloids ◽  
Marine Fungus
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