scholarly journals Cultural bias in motor function patterns: Potential relevance for predictive, preventive, and personalized medicine

2021 ◽  
Author(s):  
Karen Otte ◽  
Tobias Ellermeyer ◽  
Masahide Suzuki ◽  
Hanna M. Röhling ◽  
Ryota Kuroiwa ◽  
...  
Keyword(s):  
Personalized Medicine ◽  
Motor Function ◽  
Motor Performance ◽  
Body Height ◽  
Healthy Adults ◽  
Cultural Bias ◽  
Full Potential ◽  
Japanese Adults ◽  
Body Stature ◽  
Motion Assessment

Abstract Background Quantification of motor performance has a promising role in personalized medicine by diagnosing and monitoring, e.g. neurodegenerative diseases or health problems related to aging. New motion assessment technologies can evolve into patient-centered eHealth applications on a global scale to support personalized healthcare as well as treatment of disease. However, uncertainty remains on the limits of generalizability of such data, which is relevant specifically for preventive or predictive applications, using normative datasets to screen for incipient disease manifestations or indicators of individual risks. Objective This study explored differences between healthy German and Japanese adults in the performance of a short set of six motor tests. Methods Six motor tasks related to gait and balance were recorded with a validated 3D camera system. Twenty-five healthy adults from Chiba, Japan, participated in this study and were matched for age, sex, and BMI to a sample of 25 healthy adults from Berlin, Germany. Recordings used the same technical setup and standard instructions and were supervised by the same experienced operator. Differences in motor performance were analyzed using multiple linear regressions models, adjusted for differences in body stature. Results From 23 presented parameters, five showed group-related differences after adjustment for height and weight (R2 between .19 and .46, p<.05). Japanese adults transitioned faster between sitting and standing and used a smaller range of hand motion. In stepping-in-place, cadence was similar in both groups, but Japanese adults showed higher knee movement amplitudes. Body height was identified as relevant confounder (standardized beta >.5) for performance of short comfortable and maximum speed walks. For results of posturography, regression models did not reveal effects of group or body stature. Conclusions Our results support the existence of a population-specific bias in motor function patterns in young healthy adults. This needs to be considered when motor function is assessed and used for clinical decisions, especially for personalized predictive and preventive medical purposes. The bias affected only the performance of specific items and parameters and is not fully explained by population-specific ethnic differences in body stature. It may be partially explained as cultural bias related to motor habits. Observed effects were small but are expected to be larger in a non-controlled cross-cultural application of motion assessment technologies with relevance for related algorithms that are being developed and used for data processing. In sum, the interpretation of individual data should be related to appropriate population-specific or even better personalized normative values to yield its full potential and avoid misinterpretation.

Development of the corticospinal system and hand motor function: central conduction times and motor performance tests

2000 ◽  
Vol 42 (4) ◽  
pp. 220-227 ◽  
Author(s):  
U M Fietzek ◽  
F Heinen ◽  
S Berweck ◽  
S Maute ◽  
A Hufschmidt ◽  
...  
Keyword(s):  
Motor Function ◽  
Motor Performance ◽  
Performance Tests ◽  
Corticospinal System

scholarly journals Detection of 15-bp Deletion Mutation within PLAG1 Gene and Its Effects on Growth Traits in Goats

Animals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 2064
Author(s):  
Zhenyu Wei ◽  
Ke Wang ◽  
Hui Wu ◽  
Zhen Wang ◽  
Chuanying Pan ◽  
...  
Keyword(s):  
Body Weight ◽  
Growth Traits ◽  
Body Height ◽  
The Body ◽  
Chest Circumference ◽  
Dairy Goat ◽  
Cashmere Goat ◽  
Indel Mutation ◽  
Body Stature ◽  
Body Index

Stature and weight are important growth and development traits for animals, which also significantly affect the productivity of livestock. Polymorphic adenoma gene 1 (PLAG1) is located in the growth-related quantitative trait nucleotides (QTN), and its variation has been determined to significantly affect the body stature of bovines. This study found that novel 15-bp InDel could significantly influence important growth traits in goats. The frequencies of genotypes of the 15-bp mutation and relationship with core growth traits such as body weight, body height, height at hip cross, chest circumference, hip width and body index were explored in 1581 individuals among 4 Chinese native goat breeds. The most frequent genotypes of Shaanbei white Cashmere goat (SWCG), Inner Mongolia White Cashmere goat (IMCG) and Guanzhong Dairy goat (GZDG) were II genotypes (insertion/insertion), and the frequency of ID genotype (insertion/deletion) was found to be slightly higher than that of II genotype in Hainan Black goat (HNBG), showing that the frequency of the I allele was higher than that of the D allele. In adult goats, there were significant differences between 15-bp variation and body weight, chest circumference and body height traits in SWCG (p < 0.05). Furthermore, the locus was also found to be significantly correlated with the body index of HNBG (p = 0.044) and hip width in GZDG (p = 0.002). In regard to lambs, there were significant differences in height at the hip cross of SWCG (p = 0.036) and hip width in IMWC (p = 0.005). The corresponding results suggest that the 15-bp InDel mutation of PLAG1 is associated with the regulation of important growth characteristics of both adult and lamb of goats, which may serve as efficient molecular markers for goat breeding.

scholarly journals Contributions of HFE polymorphisms to brain and blood iron load, and their links to cognitive and motor function in healthy adults

2021 ◽  
Author(s):  
Grégoria Kalpouzos ◽  
Francesca Mangialasche ◽  
Farshad Falahati ◽  
Erika J Laukka ◽  
Goran Papenberg
Keyword(s):  
Motor Function ◽  
Healthy Adults ◽  
Iron Load

The Relationship between Aquatic Independence and Gross Motor Function in Children with Neuro-Motor Impairments

2006 ◽  
Vol 23 (4) ◽  
pp. 339-355 ◽  
Author(s):  
Miriam Getz ◽  
Yeshayahu Hutzler ◽  
Adri Vermeer
Keyword(s):  
Motor Function ◽  
Motor Performance ◽  
Motor Impairments ◽  
Gross Motor ◽  
Gross Motor Function ◽  
Gross Motor Function Measure ◽  
Scale Scores ◽  
The Relationship ◽  
Pearson Correlations ◽  
Function Measure

The purpose of this study was to investigate the relationship between motor performance in the aquatic setting as measured by the Aquatic Independence Measure (AIM) to motor performance on land as measured by the Gross Motor Function Measure (GMFM) and the Pediatric Evaluation of Disability Inventory (PEDI). Fourty- nine children with neuro-motor impairments ages 3 to 7 participated in the study. Pearson correlations were applied to determine the relationships between the AIM and the GMFM, PEDI, and Gross Motor Function Classification System (GMFCS). Significant correlations were found between the total AIM and GMFM scores (r = 69, p < .01) and PEDI self-care sub-scale (r = .79, p < .01) as well as the PEDI mobility sub-scale scores (r = .35, p < .05). The water adjustment sub-scale as measured by the AIM showed the strongest relationship to motor performance on land as measured by the GMFM and PEDI in our sample of 49 children.

PHYSICAL THERAPY INTERVENTION FOR PATIENT WITH EAST SYNDROME- A CASE STUDY.

2021 ◽  
pp. 74-77
Author(s):  
Kinjal Bagthariya(M.P.T)
Keyword(s):  
Physical Therapy ◽  
Motor Function ◽  
Motor Performance ◽  
Treatment Approach ◽  
Sensorineural Deafness ◽  
Gross Motor ◽  
East Syndrome ◽  
Therapy Intervention ◽  
Physical Therapy Intervention

EAST syndrome is autosomal recessive disorder due to mutations in gene KCNJ10, a gene encoding a potassium channel expressed in the brain, eye, ear and kidney. It is characterized by four cardinal features; Epilepsy, Ataxia, Sensorineural deafness, and renal salt-wasting Tubulopathy, thus the acronym EAST syndrome. It was rst described as a distinct clinical entity in 2009 by Bockenhauer and scholl, who named this condition EAST syndrome and SeSAME syndrome for Seizures, Sensorineural deafness, Ataxia, Mental retardation and Electrolyte imbalance respectively. Neurodevelopmental delay is evident in most patients with EAST syndrome that were old enough to be assessed; Thus, physiotherapy intervention also plays a vital role in EAST syndrome along with medical management. From physiotherapy perspective; symptomatic management to Improve overall health, wellbeing and motor control becomes ultimate goal in the patient with EAST syndrome. As there is no specic physical therapy treatment approach and no specic tool to evaluate function for children with EAST syndrome; for clinically presented delay development and ataxia, Neurodevelopment therapy (NDT) was utilized as treatment approach and Gross motor function measure (GMFM) & Gross motor performance measure (GMPM) were utilized for assessment in this case study to track progress on follow ups. Result showed marked improvement in GMFM and GMPM scores at follow ups and concluded that Physical therapy intervention improves the gross motor function as well as gross motor performance in patient with EAST syndrome.

Cerebellum

2021 ◽  
pp. 147-157
Author(s):  
Anhar Hassan
Keyword(s):  
Motor Function ◽  
Motor Performance ◽  
Posterior Lobe ◽  
Functional Zones ◽  
And Behavior ◽  
Primary Fissure

The cerebellum is crucial for planning, executing, terminating, and learning movements. The cerebellum compares actual with intended motor performance and optimizes the timing of motor function. Thus, it is important in the adaptation of movement and posture. In addition, the cerebellum contributes to cognition and behavior. The primary fissure divides the cerebellum anatomically into anterior and posterior lobes. The posterior lobe is divided from the flocculonodular lobe by the posterolateral fissure. The cerebellum may also be divided into functional zones, including the vermis (midline), paravermal region, and hemispheres (most lateral).

The concept of “normal” movement and its consequences for therapy

1996 ◽  
Vol 19 (1) ◽  
pp. 79-79
Author(s):  
Jürgen Konczak ◽  
Johannes Dichgans
Keyword(s):  
Motor Function ◽  
Motor Performance ◽  
Adaptive Changes ◽  
Normal Movement ◽  
Improve Motor Function

AbstractThe guideline for therapy should be the improvement of the individual's functionality, not the acquisition of the ill-defined “goldstandard” of normal movement. However, Latash & Anson's suggestion that only primary causes of dysfunction should be treated is problematic for two reasons: First, the distinction between genuine and adaptive changes in motor performance is not always possible, and second, adaptive changes do not necessarily improve motor function, but may actually be detrimental to the system's performance.

scholarly journals An Application of Upper-Extremity Constraint-Induced Movement Therapy in a Patient With Subacute Stroke

1999 ◽  
Vol 79 (9) ◽  
pp. 847-853 ◽  
Author(s):  
Sarah Blanton ◽  
Steven L Wolf
Keyword(s):  
Upper Extremity ◽  
Motor Function ◽  
Internal Capsule ◽  
Movement Therapy ◽  
Self Report ◽  
Full Potential ◽  
Posterior Limb ◽  
Constraint Induced Movement Therapy ◽  
Subacute Stroke

Abstract Background and Purpose. The purpose of this case report is to demonstrate the application of constraint-induced movement therapy with an individual with upper-extremity hemiparesis within 4 months after sustaining a cerebrovascular accident (stroke). Such patients often fail to develop full potential use of their affected upper extremity, perhaps due to a “learned nonuse phenomenon.” Case Description. The patient was a 61-year-old woman with right-sided hemiparesis resulting from an ischemic lacunar infarct in the posterior limb of the left internal capsule. The patient's less-involved hand was constrained in a mitten so that she could not use the hand during waking hours, except for bathing and toileting. On each weekday of the 14-day intervention period, the patient spent 6 hours being supervised while performing tasks using the paretic upper extremity. Pretreatment, posttreatment, and 3-month follow-up outcome measures included the Wolf Motor Function Test and the Motor Activity Log (MAL). Outcomes. For the Wolf Motor FunctionTest, both the mean and median times to complete 16 tasks improved from pretreatment to posttreatment and from posttreatment to follow-up. Results of the MAL indicated an improved self-report of both “how well” and “how much” the patient used her affected limb in 30 specified daily tasks. These improvements persisted to the follow-up. Discussion. Two weeks of constraining the unaffected limb, coupled with practice of functional movements of the impaired limb, may be an effective method for restoring motor function within a few months after cerebral insult. Encouraging improvements such as these strongly suggest the need for a group design that would explore this type of intervention in more detail.

Relation of exercise capacity to comprehensive physical functions in individuals with ischemic stroke

2021 ◽  
pp. 1-9
Author(s):  
So-Young Ahn ◽  
Nam-Gi Lee ◽  
Tae-Heon Lee
Keyword(s):  
Ischemic Stroke ◽  
Exercise Capacity ◽  
Motor Function ◽  
Significant Relationship ◽  
Motor Performance ◽  
Physical Parameters ◽  
Walk Test ◽  
Stroke Patients ◽  
Physical Functions ◽  
Control Balance

BACKGROUND: Impaired motor control, balance, muscle strength, and respiratory function may affect the exercise capacity related to motor performance and activities in individuals with stroke. OBJECTIVE: To identify a physical parameter that the exercise capacity has the most significant relationship among physical parameters related to motor function, trunk control, balance, and motor performance and activities in individuals with ischemic stroke. METHODS: In total, 241 ischemic stroke patients were recruited in this retrospective study. The clinical measurements included the 6-minute walk test (6 MWT), Montreal cognitive assessment (MoCA), Fugl-Meyer assessment-lower extremity motor function (FMA-LE), trunk impairment scale (TIS), Berg balance scale (BBS), timed up and go test (TUG), 10-meter walk test (10 MWT), functional ambulation category (FAC), and functional independence measure (FIM). RESULTS: The 6 MWT was significantly correlated with the FMA-LE, BBS, TUG, 10 MWT, FAC, and FIM, indicating negative or positive moderate correlations. Additionally, the FMA-LE, TIS, BBS, TUG, 10 MWT, FAC, and FIM, excluding the 6 MWT, showed moderate to strong correlations with all of the other outcome measures, whereas the MoCA showed significant correlations only with the BBS and FIM. CONCLUSIONS: In this study, the exercise capacity has the most significant relationship with the TUG parameter in stroke patients. Additionally, we suggest that significant relationships between 6 MWT and other comprehensive physical functions measurements are closely related to walking ability in individuals with stroke.

Sign in / Sign up

Export Citation Format

Share Document